Abstract
Pericytes are critical for vascular morphogenesis and contribute to several pathologies, including cancer development and progression. The mechanisms governing pericyte migration and differentiation are complex and have not been fully established. Current literature suggests that platelet-derived growth factor/platelet-derived growth factor receptor-β, sphingosine 1-phosphate/endothelial differentiation gene-1, angiopoietin-1/tyrosine kinase with immunoglobulin-like and EGF-like domains 2, angiopoietin-2/tyrosine kinase with immunoglobulin-like and EGF-like domains 2, transforming growth factor β/activin receptor-like kinase 1, transforming growth factor β/activin receptor-like kinase 5, Semaphorin-3A/Neuropilin, and matrix metalloproteinase activity regulate the recruitment of pericytes to nascent vessels. Interestingly, many of these pathways are directly affected by secreted protein acidic and rich in cysteine (SPARC). Here, we summarize the function of these factors in pericyte migration and discuss if and how SPARC might influence these activities and thus provide an additional layer of control for the recruitment of vascular support cells. Additionally, the consequences of targeted inhibition of pericytes in tumors and the current understanding of pericyte recruitment in pathological environments are discussed.
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Acknowledgments
We gratefully acknowledge Drs. Michael Dellinger and Bercin Cenik and other members of the Brekken laboratory for helpful comments on the manuscript, as well as Richard Howdy at Visually Medical for preparation of the illustrations. Supported by The Effie Marie Cain Scholarship in Angiogenesis Research (RAB) and grants from the NIH; R01CA118240 (R.A.B.) and F31 CA168350 (K.Y.A.).
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Aguilera, K.Y., Brekken, R.A. Recruitment and retention: factors that affect pericyte migration. Cell. Mol. Life Sci. 71, 299–309 (2014). https://doi.org/10.1007/s00018-013-1432-z
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DOI: https://doi.org/10.1007/s00018-013-1432-z