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Navigation rules for vessels and neurons: cooperative signaling between VEGF and neural guidance cues

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Abstract

Many organs, such as lungs, nerves, blood and lymphatic vessels, consist of complex networks that carry flows of information, gases, and nutrients within the body. The morphogenetic patterning that generates these organs involves the coordinated action of developmental signaling cues that guide migration of specialized cells. Precision guidance of endothelial tip cells by vascular endothelial growth factors (VEGFs) is well established, and several families of neural guidance molecules have been identified to exert guidance function in both the nervous and the vascular systems. This review discusses recent advances in VEGF research, focusing on the emerging role of neural guidance molecules as key regulators of VEGF function during vascular development and on the novel role of VEGFs in neural cell migration and nerve wiring.

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Acknowledgments

We are grateful to J.L. Thomas, A. Eichmann, and C. Ruhrberg for critical reading of the manuscript. This work was supported in part by the Centre National de la Recherche Scientifique, the Aix-Marseille University, the Institut Universitaire de France, the Agence Nationale de la Recherche (ANR-10-BLAN-1412, Angioneurins), the Fédération pour la Recherche sur le Cerveau and the Institut National du Cancer (2011-139).

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    Sophie Chauvet, Katja Burk & Fanny Mann

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Chauvet, S., Burk, K. & Mann, F. Navigation rules for vessels and neurons: cooperative signaling between VEGF and neural guidance cues. Cell. Mol. Life Sci. 70, 1685–1703 (2013). https://doi.org/10.1007/s00018-013-1278-4

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