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Effect of vitamin E on platelet enzymatic anti-oxidants in the patients of myocardial infarction

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Abstract

Effect of administration of 600 mg. vitamin E each day, for six days, was observed on activity of some of the anti-oxidant enzymes and levels of malondialdehyde (as an index of free radical mediated damage) in the platelets of patients reperfused after myocardial infarction. It has been found that vitamin E administration significantly lowers the level of malondialdehyde in the patients. Vitamin E administration increases the activities of anti oxidant enzymes (viz. superoxide dismutase, glutathione reductase and catalase) tested both in the patients and healthy controls. Vitamin E administration causes general stimulation of anti-oxidant enzyme activities both in healthy persons and the patients, however, lowering of lipid per-oxidation upon administration of vitamin E is specific for patients. These findings exhibit beneficial role of vitamin E administration in the management of the patients reperfused after myocardial infarction.

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Authors and Affiliations

  1. Department of Biochemistry, University of Lucknow, 226 007, Lucknow

    Vivek K. Dwivedi, P. C. Misra & M. K. Misra

  2. C.S.M. Medical University, Lucknow

    Mahesh Chandra

Authors
  1. Vivek K. Dwivedi
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  2. Mahesh Chandra
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  3. P. C. Misra
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  4. M. K. Misra
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Correspondence to M. K. Misra.

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Dwivedi, V.K., Chandra, M., Misra, P.C. et al. Effect of vitamin E on platelet enzymatic anti-oxidants in the patients of myocardial infarction. Indian J Clin Biochem 20, 21–25 (2005). https://doi.org/10.1007/BF02893036

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