Skip to main content
SpringerLink
Log in

Hyperosmotic secretion at low transport rates in the cat sweat gland

Evidence for two separate potassium-release mechanisms

  • Published:
Pflügers Archiv Aims and scope Submit manuscript

Summary

The hypertonicity of the secretory fluid produced by the cat sweat gland is due to a potassium release mechanism which operates in series with an isosmotic NaCl transport process.

The potassium excretion rate is not coupled with volume flow but is determined by the frequency of electrical stimulation.

Evidence is presented for the presence of two potassium release mechanisms during the secretory process. A small potassium flux is due to cellular redistribution at the onset of stimulation potassium secretion perhaps originating from dark cells. The major potassium flux is related to the bicarbonate excertion rate.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Burgen, A. S. V.: The secretion of potassium in saliva. J. Physiol. (Lond.)132, 20–39 (1956)

    Google Scholar 

  • Diamond, J. M., Bossert, W. H.: Standing-gradient osmotic flow; a mechanism for coupling of water and solute transport in epithelia. J. gen. Physiol.50, 2061–2083 (1967)

    Google Scholar 

  • Dobson, R. L., Slegers, J. F. G.: The effect of aldosterone on sweating in the cat. J. invest. Derm.56, 337–339 (1971)

    Google Scholar 

  • Finn, A. L., Nellans, H.: The kinetics and distribution of potassium in the toad bladder. J. Membrane Biol.8, 189–203 (1972)

    Google Scholar 

  • Foster, K. G.: Composition of the secretion from the eccrine sweat glands of the cat foot pad. J. Physiol. (Lond.)184, 106–119 (1966)

    Google Scholar 

  • Giebisch, G., Boulpaep, E. L., Whittembury, G.: Electrolyte transport in kidney tubule cells. Phil. Trans.262, 175–196 (1971)

    Google Scholar 

  • Gruber, W. D., Knauf, H., Frömter, E.: The effect of aldosterone and actinomycin D on cation transport in salivary duct. Pflügers Arch.312, 91 (1969)

    Google Scholar 

  • Ikai, K., Sugiyama, K., Otsuka, Y., Nitta, H.: A preliminary note on adrenergic mechanism of sweat secretion and the sweat electrolyte concentration in man. Jap. J. Physiol.20, 250–259 (1970)

    Google Scholar 

  • Knauf, H.: The isolated salivary duct as a model for electrolyte transport studies. Pflügers Arch.333, 82–94 (1972)

    Google Scholar 

  • Martin, C. J., Young, J. A.: Electrolyte concentrations in primary and final saliva of the rat sublingual gland studied by micropuncture and catheterization techniques. Pflügers Arch.324, 344–360 (1971)

    Google Scholar 

  • Munger, B. L., Brusilow, S. W.: An electron microscopic study of eccrine sweat glands of the cat foot and toe pads-Evidence for ductal reabsorption in the human. J. biophys. biochem. Cytol.11, 403–417 (1961)

    Google Scholar 

  • Perheentupa, J., Harrison, H. C., Harrison, H. E.: Electrolyte transport by bullfrog colon in vitro. Biochim. biophys. Acta (Amst.)255, 858–872 (1972)

    Google Scholar 

  • Petersen, O. H.: The effect of dinitrophenol on secretory potentials, secretion and potassium accumulation in the perfused cat submandibular gland. Acta physiol. scand.80, 117–121 (1970)

    Google Scholar 

  • Petersen, O. H.: Formation of saliva and potassium transport in the perfused cat submandibular gland. J. Physiol. (Lond.)216, 129–142 (1971)

    Google Scholar 

  • Petersen, O. H., Poulsen, J. H.: Excretion of sodium potassium in cat submandibular saliva. Acta physiol. scand.70, 158–167 (1967)

    Google Scholar 

  • Richet, G., Gabe, M.: Correlations entre les transferts de bicarbonate et la morphologie du segment terminal du nephron chez le rat. Nephron7, 413–429 (1970)

    Google Scholar 

  • Schneyer, L. H., Young, J. A., Schneyer, Ch. A.: Salivary secretion of electrolytes. Physiol. Rev.52, 720–777 (1972)

    Google Scholar 

  • Schulz, I. J.: Micropuncture studies of the sweat formation in cystic fibrosis patients. J. clin. Invest.48, 1470–1477 (1969)

    Google Scholar 

  • Slegers, J. F. G.: Ionic secretion by epithelial membranes. In: R. Poter and M. O'Connor: Cystic Fibrosis, Ciba Foundation, pp. 68–85. London: Churchill 1968

    Google Scholar 

  • Slegers, J. F. G., Hof-Grootenboer, A. E. van't: The localization of sodium transport sites in a forward pumping secretory system. Pflügers Arch.327, 167–185 (1971)

    Google Scholar 

  • Slegers, J. F. G., Moons, W. M.: Effect of acetazolamide on the chloride shift and the sodium pump in secretory cells. Nature (Lond.)220, 181–182 (1968)

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, University of Nijmegen, The Netherlands

    J. F. G. Slegers & W. M. Moons

Authors
  1. J. F. G. Slegers
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. M. Moons
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Slegers, J.F.G., Moons, W.M. Hyperosmotic secretion at low transport rates in the cat sweat gland. Pflugers Arch. 343, 49–63 (1973). https://doi.org/10.1007/BF00586574

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00586574

Key words

Search

Navigation