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Importance of laboratory clinical investigation in the diagnosis of immune vasculitis with neurological manifestation

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Summary

In this study 23 cases of immune vasculities with predominance of neurological symptoms were analysed. Besides patient history and neurological examination, myelotomy is the most relevant means of diagnosis in immune vasculitis. For this reason myelotomy should be intergrated in routine diagnostic methods if the diagnosis immune vasculitis is discussed. Other laboratory parameters have no great relevance in the diagnosis of immune vasculitis. A higher specificity of antibody tests, especially in the case of ANA, might be able to replace myelotomy in the diagnosis of immune vasculitis. The relevance of laboratory parameters in the diagnosis of immune vasculitis in neurological patients was examined.

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References

  1. Bernhards J (1983) Immunogene Veränderungen des Knochenmarkmesenchyms bei Erkrankungen aus dem rheumatischen Formenkreis. Unveröffentliche Doktorarbeit (Med Hochschule Hannover)

  2. Burkhardt R (1965) The bone marrow in systemic lupus erythematosus. Sem Hematol 2:29–46

    CAS  Google Scholar 

  3. Burkhardt R (1967) Histomorphologische Untersuchungen über die Rolle des Knochenmarkes bei rheumatischen Krankheiten. Z Ges Exp Med 143:1–66

    Article  CAS  Google Scholar 

  4. Burkhardt R, Beil E (1971) Die diagnostische Aussage der Myelotomie. Klin Wochenschr 49:422–426

    Article  CAS  PubMed  Google Scholar 

  5. Calin A (1980) Die Behandlung der Kollagen-Krankheiten. Der Internist 21:697–701

    CAS  PubMed  Google Scholar 

  6. Gemünd HR, Mitrenga D, Schumacher K (1978) Vergleichende Untersuchung zum Nachweis antinukleärer Antikörper unter besonderer Berücksichtigung des Lupus erythematodes disseminatus. Verh Dtsch Ges Inn Med 84:1307–1311

    PubMed  Google Scholar 

  7. Gottwald W (1980) Neurologische und psychiatrische Syndrome des Erythematodes. Krankenhausarzt 53:127–129

    Google Scholar 

  8. Hamburger M, Hodes S, Barland P (1977) The incidence and clinical significance of antibodies to extractable nuclear antigens. Am J Med Sci 273:21–28

    Article  CAS  PubMed  Google Scholar 

  9. Helmke K, Schäfer B, Federlin K (1978) Vergleichende Untersuchung zum Nachweis antinukleärer Faktoren. Verh Dtsch Ges Inn Med 84:1304–1307

    CAS  PubMed  Google Scholar 

  10. Herrmann D, Kunze K (1982) Elektromyographie und gezielte Muskelbiopsie bei Kollagenosen. In: Struppler A (Hrsg) Elektrophysiologische Diagnostik in der Neurologie. Thieme Verlag, pp 88–89

  11. Hohmeister R, Bresnihan B, Hughes GRV (1978) Neuropsychiatrische Manifestationen bei Patienten mit Lupus erythematosus disseminatus. Schweiz Med Wochenschr 108:2007–2012

    CAS  PubMed  Google Scholar 

  12. Johnson RT, Richardson EP (1968) The neurological manifestations of systemic Lupus erythematosus. Medicine 47:337–369

    Article  CAS  PubMed  Google Scholar 

  13. Korting GW (1967) Über einige Wesensunterschiede von Sklerodermie, Dermatomyositis und Lupus erythematodes acutus und die darauf basierende differente Therapie. Dtsch Med Wochenschr 92:281–288

    Article  CAS  PubMed  Google Scholar 

  14. Leibfarth JH, Persellin RH (1976) Characteristics of patients with serum antibodies to extractable nuclear antigens. Arthritis Rheum 19:851–856

    Article  CAS  PubMed  Google Scholar 

  15. Moore PM, Fauci AS (1981) Neurologic manifestations of systemic vasculitis. Am J Med 71:517–524

    Article  CAS  PubMed  Google Scholar 

  16. Northway JD, Tan EM (1972) Differentiation of antinuclear antibodies giving speckled staining patterns in immunofluorescence. Clin Immun Immunopathol 1:140–154

    Article  CAS  Google Scholar 

  17. Rosenthal M (1976) Das Sharp-syndrom (“mixed connective tissue disease”). Schweiz Med Wochenschr 106:129–134

    CAS  PubMed  Google Scholar 

  18. Rosenthal M, Stojan B, Müller W (1976) Differenzierung der antinukleären Antikörper zur Verbesserung ihrer diagnostischen Aussagekraft. Dtsch Med Wochenschr 101:379–384

    Article  CAS  PubMed  Google Scholar 

  19. Schumacher K (1982) Immunsuppressive Therapie der Autoimmunvaskulitiden und Bindegewebserkrankungen. Dtsch Ärzteblatt 79:37–45

    Google Scholar 

  20. Senff SH (1983) Die Bedeutung laborchemischer Untersuchungen für die Diagnostik neurologischer Krankheitsbilder bei Immunvaskulitiden. Unveröffentlichte Doktorarbeit (Hamburg)

  21. Sharp GC, Irvin WS, La Roque RL, Velez C, Daly V, Kaiser AD, Holman HR (1971) Association of autoantibodies to different nuclear antigens with clinical patterns of rheumatic disease and responsiveness to therapy. J Clin Invest 50:350–359

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Sharp GC, Irvin WS, Tan EM, Gould RG, Holman HR (1972) Mixed connective tissue disease — an apparently distinct rheumatic disease syndrome associated with a specific antibody to an extractable nuclear antigen (ENA). Am J Med 52:148–159

    Article  CAS  PubMed  Google Scholar 

  23. Sharp GC, Irvin WS, May CM, Holman HR, McDuffie FC, Hess EV, Schmid FR (1976) Association of antibodies to ribonucleoprotein and Sm-antigens with mixed connective-tissue dieseae, systemic Lupus erythematosus and other rheumatic diseases. J Med 295:1149–1154

    CAS  Google Scholar 

  24. Thomas L (1978) Labor und Diagnose. Die Medizinische Verlagsgesellschaft Marburg/Lahn

    Google Scholar 

  25. Wold RT, Young FE, Tan EM, Farr RS (1968) Deoxyribonucleic acid antibody: A method to detect its primary interaction with deoxyribonucleic acid. Science 161:806–807

    Article  CAS  PubMed  Google Scholar 

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Hagenah, R., Senff, S.H. Importance of laboratory clinical investigation in the diagnosis of immune vasculitis with neurological manifestation. Eur Arch Psychiatr Neurol Sci 234, 92–96 (1984). https://doi.org/10.1007/BF00381213

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