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Affective status in relation to impulsive, motor and motivational symptoms: Personality, development and physical exercise

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Abstract

The contributions of impulsive and risk-taking behaviour in depressive and bipolar disorders, motivational and motor behaviours in anhedonic and substance addictive states, and the factors, particularly distress and trauma, underlying the development of neuropathology in affective status are described from clinical, epidemiological and laboratory perspectives. In order to distinguish one case factor for biopsychological substrates of health, an array of self-reported characteristics, e.g., positive or negative affect, stress or energy, optimism, etc., that may be predictive or counterpredictive for the propensity for physical exercise and activity were analysed using a linear regression in twelve different studies. Several individual characteristics were found to be markedly and significantly predictive of the exercise propensity, i.e., positive affect, energy, health-seeking behaviour and character, while optimism was of lesser, though significant, importance. Several individual characteristics were found to be significantly counterpredictive: expression of BDI- and HAD-depression, major sleep problems and lack/negligence of healthseeking behaviour. The consequences of physical activity and exercise for both affective well-being, cognitive mobility and neurogenesis is noted, particularly with regard to developmental assets for younger individuals. Affective disorder states may be studied through analyses of personal characteristics that unfold predispositions for symptom-profiles and biomarkers derived from properties of dysfunction, such as impulsiveness, temperament dimensions, anhedonia and ’over-sensitivity’, whether interpersonal or to reward.

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References

  • Adler CM, SK Holland, V Schmithorst, M Wilke, KL Weiss, H Pan and SM Strakowski (2004) Abnormal frontal white matter tracts in bipolar disorder: a diffusion tensor imaging study.Bipolar Disord. 20, 197–203.

    Article  Google Scholar 

  • Adriani W and G Laviola (2008) Animal models and mechanisms of impulsivity in adolescence, In:Beyond Neuropsychiatric Diagnostics: Symptoms Not Diagnostics (Palomo T, RJ Beninger, RM Kostrzewa and T Archer (Fundacion Cerebro y Mente:Madris, Spain) (in press).

  • Adriani W, A Caprioli, O Granström, M Carli and G Laviola (2003) The spontaneously-hypertensive-rat as an animal model of ADHD: evidence for impulsive and non-impulsive subpopulations.Neurosci. Biobehav. Rev. 27, 639–651.

    Article  PubMed  Google Scholar 

  • Adriani W, M Rea, M Baviera, W Invernizzi, M Carli, O Ghirardi, A Caprioli and G Laviola (2004) Acetyl-L-carnitine reduces impulsive behaviour in adolescent rats.Psychopharmacology 176, 296–304.

    Article  PubMed  CAS  Google Scholar 

  • Adriani W, R Canese, F Podo and G Laviola (2007) 1HMRS-detectable metabolic brain changes and reduced impulsive behaviour in adult rats exposed to methylphenidate during adolescence.Neurotoxicol. Teratol. 29, 116–125.

    Article  PubMed  CAS  Google Scholar 

  • Altshuler LL, G Bartzokis, T Grieder, J Curran and J Mintz (1998) Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: an MRI study demonstrating neuroanatomic specificity.Arch. Gen. Psychiatry 55, 663–664.

    Article  PubMed  CAS  Google Scholar 

  • American College of Sports Medicine (1998) The recommended quantity and quality of exercise for developing and maintaining cardiorespiratory and muscular fitness, and flexibility in healthy adults.Med. Sci. Sport. Exercise 30, 975–991.

    Article  Google Scholar 

  • Anderson BJ, DN Rapp, DH Baek, DP McCloskey, PS Coburn-Litvak and JK Robinson (2000) Exercise influences spatial learning in the radial arm maze.Physiol. Behav. 70, 425–429.

    Article  PubMed  CAS  Google Scholar 

  • Andersson-Arntén A-C, B Jansson and T Archer (2008) Self-reported partnership relations and work stress as predictors of health and illhealth. in review.

  • Archer T, L Adrianson, A Plancak and E Karlsson (2007) Influence of affective personality on cognition-mediated emotional processing: need for empowerment.Eur. J. Psychiatry 21, 248–262.

    Google Scholar 

  • Archer T, B Adolfsson and E Karlsson (2008) Affective personality as cognitive-emotional presymptom profiles regulatory for self-reported health predispositions.Neurotox. Res. 14, 21–44.

    PubMed  CAS  Google Scholar 

  • Arnett J (1992) Reckless behaviour in adolescence: a developmental perspective.Dev. Rev. 12, 339–373.

    Article  Google Scholar 

  • Avila C and MA Parcet (2000) The role of Gray’s impulsivity in anxiety-mediated differences in resistence to extinction.Eur. J. Personality 14, 185–198.

    Article  Google Scholar 

  • Avila C and MA Parcet (2001) Personality and inhibitory deficits in the stop-signal task: the mediating role of Gray’s anxiety and impulsivity.Person. Individ. Diff. 29, 975–986.

    Article  Google Scholar 

  • Avila C and R Torrubia (2004) Personality, expectations and response to multiple choice question examinations in university students: a test of Gray’s hypotheses.Eur. J. Personality 18, 45–59.

    Article  Google Scholar 

  • Avila C, MA Parcet and A Barros-Loscertales (2008) A cognitive neuroscience approach to individual differences in sensitivity to reward.Neurotox. Res. 14, 181–193.

    Google Scholar 

  • Baca-Garcia E, C Diaz-Sastre, E García Resa, H Blasco, D Braquehais Conesa, MA Oquendo, J Saiz-Ruiz and J de Leon (2005) Suicide attempts and impulsivity.Eur. Arch. Psychiatr. Clin. Neurosci. 255(2), 152–156.

    Article  Google Scholar 

  • Baldessarini RJ and L Tondo (2003) Suicide risk and treatments for patients with bipolar disorder.JAMA 290, 1517–1519.

    Article  PubMed  CAS  Google Scholar 

  • Barratt ES and JH Patton (1983) Impulsivity: cognitive, behavioral, and psychophysiological correlates, In:Biological Basis of Sensation-seeking, Impulsivity and Anxiety (Zuckerman M, Ed.) (LEA:Hillsdale, NJ), pp 77–116.

    Google Scholar 

  • Barros-Loscertales A, V Meseguer, A Sanjuan, V Belloch, MA Parcet, R Torrubia and C Avila (2006) Striatum gray matter reduction in males with an overactive behaviour activation system.Eur. J. Neurosci. 24, 2071–2074.

    Article  PubMed  CAS  Google Scholar 

  • Beaver JD, J Lawrence, J Van Ditzhuizen, MH Davis, A Woods and AJ Calder (2006) Individual differences in reward drive predict neural responces to images of food.J. Neurosci. 26, 5160–5166.

    Article  PubMed  CAS  Google Scholar 

  • Beck AT and RA Steer (1987)Manual for the Revised Beck Depression Inventory. (Psychological Corp.:San Antonio, TX).

    Google Scholar 

  • Binder E, SK Droste, F Ohl and JM Reul (2004) Regular voluntary exercise reduces anxiety-related behaviour and impulsiveness in mice.Behav. Brain Res. 155, 197–206.

    Article  PubMed  Google Scholar 

  • Blumberg HP, NH Donegan, CA Sanislowet al. (2005) Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder.Psychopharmacology 183, 308–313.

    Article  PubMed  CAS  Google Scholar 

  • Bornstein R (1998) Reconceptualising personality disorder diagnosis in the DSM-IV: the discriminant validity challenge.Clin. Psychol. Sci. Prac. 5, 333–343.

    Google Scholar 

  • Bowden CL (2005) A different depression: clinical distinctions between bipolar and unipolar depression.J. Affect. Disord. 84, 117–125.

    Article  PubMed  Google Scholar 

  • Boyce P and G Parker (1989) Development of a scale to measure interpersonal sensitivity.Austr. NZ J. Psychiatry 23, 341–351.

    Article  CAS  Google Scholar 

  • Brake WG, TY Zhang, J Diorio, MJ Meaney and A Gratton (2004) Influence of early postnatal rearing conditions on mesocorticolimbic dopamine and behavioural responses to psychostimulants and stressors in adult rats.Eur. J. Neurosci. 19, 1863–1874.

    Article  PubMed  Google Scholar 

  • Bruno SD, GJ Barker, M Cercignani, M Symmsand MA Ron (2004) A study of bipolar disorder using magnetization transfer imaging and voxel-based morphometry.Brain 127, 2433–2440.

    Article  PubMed  CAS  Google Scholar 

  • Bulik CM, PF Sullivan, FA Carter and PR Joyce (1997) Lifetime comorbidity of alcohol dependence in women with bulimia nervosa.Addict. Behav. 22(4), 437–446.

    Article  PubMed  CAS  Google Scholar 

  • Burghardt PR, LJ Fulk, GA Hand and MA Wilson (2004) The effects of chronic treadmill and wheel running on behavior in rats.Brain Res. 1019, 84–96.

    Article  PubMed  CAS  Google Scholar 

  • Caberlotto L, PA Jimenez, DH Overstreet, YL Hurd, AA Mathé and K Fuxe (1999) Alterations in neuropeptide Y levels and Y1 binding sites in the Flinders Sensitive Line rats, a genetic animal model of depression.Neurosci. Lett. 265, 191–194.

    Article  PubMed  CAS  Google Scholar 

  • Carlsson A (1959) The occurrence, distribution and physiological role of catecholamines in the nervous system.Pharmacol. Rev. 11, 490–493.

    PubMed  CAS  Google Scholar 

  • Carlsson A, B Falck and N Hillarp (1962) Cellular localization of brain monoamines.Acta Physiol. Scand. Suppl.56, 1–28.

    Google Scholar 

  • Carver CS and TL White (1994) Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: the BIS/BAS scales.J. Pers. Soc. Psychol. 67, 319–333.

    Article  Google Scholar 

  • Caspi A, J McClay, TE Moffitt, J Mill, J Martin, IW Craig, A Taylor and R Poulton (2002) Role of genotype in the cycle of violence in maltreated children.Science 297, 851–854.

    Article  PubMed  CAS  Google Scholar 

  • Castro CM, JF Sallis, SA Hickmann, RE Lee and AH Chen (1999) A prospective study of psychosocial correlates of physical activity for ethnic minority women.Psychol. Health 14, 277–293.

    Article  Google Scholar 

  • Chambers RA and MN Potenza (2003) Neurodevelopment, impulsivity, and adolescence gambling.J. Gambl. Stud. 19, 53–84.

    Article  PubMed  Google Scholar 

  • Champagne FA and MJ Meaney (2006) Stress during gestation alters postpartum maternal care and the development of the offspring in a rodent model.Biol. Psychiatry 59, 1227–1235.

    Article  PubMed  CAS  Google Scholar 

  • Cloninger C, D Svrakic and R Pryzbeck (1993) A psychobiological model of temperament and character.Arch. Gen. Psychiatry 50, 975–990.

    PubMed  CAS  Google Scholar 

  • Colcombe SJ, AF Kramer, KI Erickson, P Scalf, E McAuley, NJ Cohenet al. (2004) Cardiovascular fitness, cortical plasticity, and aging.Proc. Natl. Acad. Sci. USA 101, 3316–3321.

    Article  PubMed  CAS  Google Scholar 

  • Conn VS, T Tripp-Reimer and ML Maas (2003) Older women and exercise: theory of planned behaviour beliefs.Publ. Health Nurs. 20, 153–163.

    Article  Google Scholar 

  • Corbett D and RA Wise (1979) Intracranial self-stimulation in relation to the ascending noradrenergic fiber systems of the pontine tegmentum and caudal midbrain: a moveable electrode mapping study.Brain Res. 177, 423–436.

    Article  PubMed  CAS  Google Scholar 

  • Corbett D and RA Wise (1980) Intracranial self-stimulation in relation to the ascending dopaminergic systems of the mid-brain: a moveable electrode mapping study.Brain Res. 185, 1–15.

    Article  PubMed  CAS  Google Scholar 

  • Corr PJ (2004) Reinforcement sensitivity theory and personality.Neurosci. Biobehav. Rev. 28, 317–332.

    Article  PubMed  Google Scholar 

  • Corruble E, A Benyamine, F Bayle, B Falissard and P Hardy (2003) Understanding impulsivity in severe depression? A psychometrical contribution.Prog. Neuropsychopharmacol. Biol. Psychiatry 27, 829–833.

    Article  PubMed  Google Scholar 

  • Crespo CJ, MRG Palmieri, RP Perdomo, DL McGee, E Smit, CT Sempos and PD Sorlie (2002) The relationship of physical activity and body weight with all-cause mortality: results from the Puerto Rico heart health program.Ann. Epidemiol. 12, 543–552.

    Article  PubMed  Google Scholar 

  • Deci EL and RM Ryan (1985)Intrinsic Motivation and Self-determination in Human Behaviour (Plenum:New York, NY).

    Google Scholar 

  • Deci EL and RM Ryan (1991) A motivational approach to self: integration in personality, In:Nebraska Symposium on Motivation: vol. 38. Perspectives on Motivation (Dienstbier R, Ed.) (Lincoln, University of Nebraska Press:Lincoln, NE), pp 237–288.

    Google Scholar 

  • Duchesne S and S Larose (2007)Adolescent Parental Attachment and Academic Motivation and Performance in Early Adolescence (Laval University Press:Canada).

    Google Scholar 

  • Duley AR, CH Hillman, S Coombes and CM Janelle (2007) Sensorimotor gating and anxiety: prepulse inhibition following acute exercise.Int. J. Psychophtsiol. 64, 157–164.

    Article  Google Scholar 

  • Dumais A, AD Lesage, M Alda, G Rouleau, N Dumont, N Chawky, M Roy, JJ Mann, C Benkelfat and G Turecki (2005) Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men.Am. J. Psychiatry 162, 2116–2124.

    Article  PubMed  CAS  Google Scholar 

  • Dunn JD (2008) Managed care considerations.Am. J. Manag. Care 14(6) Suppl. 2, S227-S237.

    PubMed  Google Scholar 

  • Ekecrantz L and N Norman (1991)Instructions for the Coping Resources Inventory - CRI (Psykologiförlaget:Stockholm).

    Google Scholar 

  • El Khoury A, SH Gruber, A Mörk and AA Mathé (2006) Adult life behavioural consequences of early maternal separation are alleviation by citalopram treatment in a rat model of depression.Prog. Neuropsychopharmacol. Biol. Psychiatry 30, 535–540.

    Article  PubMed  CAS  Google Scholar 

  • Engesser-Cesar C, AJ Anderson, DM Basso, VR Edgerton and CW Wotman (2005) Voluntary wheel running improves recovery from moderate spinal cord injury.J. Neurosci. 22, 157–171.

    Google Scholar 

  • Eshel N, EE Nelson, RJ Blair, DS Pine and M Ernst (2007) Neural substrates of choice selection in adults and adolescents: development of the ventrolateral prefrontal anterior cingulate cortices.Neuropsychologia 45, 1270–1279.

    Article  PubMed  Google Scholar 

  • Everitt BJ and TW Robbins (2005) Neural systems of reinforcement for drug addiction: from actions to habits to compulsion.Nat. Neurosci. 8, 1481–1489.

    Article  PubMed  CAS  Google Scholar 

  • Fabre C, K Chamari, P Mucci, J Masse-Biron and C Prefaut (2002) Improvement of cognitive function by mental and/or individualized aerobic training in healthy elderly subjects.Int. J. Sports Med. 23, 415–421.

    Article  PubMed  CAS  Google Scholar 

  • Faure A, U Haberland, F Conde and N El Massioui (2005) Lesion to the nigrostriatal dopamine system disrupts stimulus-response habit formation.J. Neurosci. 25, 2771–2780.

    Article  PubMed  CAS  Google Scholar 

  • Fibiger HC (1978) Drugs and reinforcement mechanisms: a critical review of the catecholamine theory.Ann. Rev. Pharmacol. Toxicol. 18, 37–56.

    Article  CAS  Google Scholar 

  • First MB, RL Spitzer, M Gibbon and JB Williams (1996) Structured clinical interview for DSM-IV Axis I Disorders Patent Edition.Biometrics Research Institute, New York State Psychiatric Institute.

  • Fouriezos G and RA Wise (1976) Pimozide-induced extinction of intracranial self-stimulation: response patterns rule out moyor or performance deficits.Brain Res. 103, 377–380.

    Article  PubMed  CAS  Google Scholar 

  • Fouriezos G, P Hansson and RA Wise (1978) Neuroleptic-induced attenuation of brain stimulation reward in rats.J. Comp. Physiol. Psychol. 92, 661–671.

    Article  PubMed  CAS  Google Scholar 

  • Franklin KBJ and SN McCoy (1979) Pimozide-induced extinction in rats: stimulus control of responding rules out motor deficit.Pharmacol. Biochem. Behav. 11, 71–75.

    Article  PubMed  CAS  Google Scholar 

  • Galvan A, TA Hare, CE Parra, J Penn, H Voss, G Glover and BJ Casey (2006) Earlier development of the accumbens relative to orbitofrontal cortex might underlie risk-taking behaviour in adolescents.J. Neurosci. 26, 6885–6892.

    Article  PubMed  CAS  Google Scholar 

  • Galvan A, TA Hare, H Voss, G Glover and BJ Casey (2007) Risk-taking and the adolescent brain: who is at risk?Dev. Sci. 10, F8-F14.

    Article  PubMed  Google Scholar 

  • Ghaemi SN, DJ Hsu, JY Ko, CF Baldassano, NJ Kontos and FK Goodwin (2004) Bipolar spectrum disorder: a pilot study.Psychopathology 37, 222–226.

    Article  PubMed  Google Scholar 

  • Goldstein RA and ND Volkow (2002) Drug addiction and its underlying neurobiological basis: neuroimaging evidence for the involvement of the frontal cortex.Am. J. Psychiatry 159, 1642–1652.

    Article  PubMed  Google Scholar 

  • Gomez-Pinilla F, V So and JP Kesslak (1998) Spatial learning and physical activity contribute to the induction of fibroblast growth factor: neural substrates for increased cognition associated with exercise.Neuroscience 85, 53–61.

    Article  PubMed  CAS  Google Scholar 

  • Gray JA (1970) The psychophysiological basis of introversion-extraversion.Behav. Res. Ther. 8, 249–266.

    Article  PubMed  CAS  Google Scholar 

  • Gray JA (1982)The Neuropsychology of Anxiety: an Enquiry into the Functions of the Septo-Hippocampal System (Oxford University Press:Oxford).

    Google Scholar 

  • Gray JA (1987)The Psychology of Fear and Stress (Cambridge University Press:Cambridge).

    Google Scholar 

  • Gray JA, S Owen, N Davis and E Tsaltas (1983) Psychological and physiological relations between anxiety and impulsivity, In:The Biological Bases of Sensation-seeking, Impulsivity and Anxiety (Zuckerman M, Ed.) (Erlbaum:Hillsdale, NJ), pp 189–217.

    Google Scholar 

  • Groth-Marnat G (1990)The Handbook of Psychological Assessment, 2nd Ed. (John Wiley & Sons:New York, NY).

    Google Scholar 

  • Gruber SA, J Rogowska and DA Yurgelun-Todd (2004) Decreased activation of the anterior cingulate in bipolar patients: an fMRI study.J. Affect. Disord. 82, 191–201.

    Article  PubMed  Google Scholar 

  • Hansenne M, E Pinto, W Pitchot, J Reggers, G Scantamburlo, M Mooret al. (2002) Further evidence on the relationship between dopamine and novelty seeking: a neuroendocrine study.Pers. Individ. Diff. 33, 1003–1009.

    Google Scholar 

  • Haruno M, T Kuroda, K Doya, K Toyama, M Kimura, K Samejima, H Imamizu and M Kawato (2004) A neural correlate of reward-based behavioural learning in caudate nucleus: a functional magnetic resonance imaging study of a stochastic decision task.J. Neurosci. 24, 1660–1665.

    Article  PubMed  CAS  Google Scholar 

  • Heesch KC, LC Masse, AL Dunn, RF Frankowski and PD Mullen (2003) Does adherence to a lifestyle physical activity intervention predict changes in physical activity?J. Behav. Med. 26, 333–348.

    Article  PubMed  CAS  Google Scholar 

  • Herrmann C (1997) International experiences with hospital anxiety and depression scales - a review validating data and clinical results.J. Psychosom. Res. 11, 213–218.

    Google Scholar 

  • Hetta J, M Almqvist, H Ågren, G Hambert, GB Liljenberg and BE Roos (1985) Prevalence of sleep disturbances and related symptoms in a middle-aged Swedish population, In:Sleep ’84 (Koella WP, E Ruther and H Schultz, Eds.) (Gustaf Fischer Förlag:Stuttgart, Germany), pp 373–376.

    Google Scholar 

  • Husum H, D Van Kammen, E Termeer, TG Bolwig and AA Mathé (2003) Topiramate normalizes hippocampal NPY-LI in flinders sensitive line ’depressed’ rats and upregulates NPY, galanin, and CRH-LI in the hypothalamus: implications for mood-stabilizing and weight loss-inducing effects.Neuropsychopharmacol. 28, 1292–1299.

    Article  CAS  Google Scholar 

  • Jenner H (2004)Motivation and Motivationsarbete i Skola och Behandling [Motivation and Motivated Work in School and Treatment] (Lenanders Grafiska AB:Kalmar, Sweden).

    Google Scholar 

  • Jentsch K and J Taylor (1999) Impulsivity resulting from frontostriatal dysfunction in drug abuse: implications for the control of behavior by reward-related stimuli.Psychopharmacol. 146, 373–390.

    Article  CAS  Google Scholar 

  • Jimenez-Vasquez PA, Z Diaz-Cabiale, L Caberlotto, I Bellido, DH Overstreet, K Fuxe and AA Mathé (2007) Electroconvulsive stimuli selectively affect behaviour and neuropeptide Y (NPY) and NPY Y(1) receptor gene expressions in hippocampus and hypothalamus of Flinders Sensitive Line rat model of depression.Eur. Neuropsychopharmacol. 17, 298–308.

    Article  PubMed  CAS  Google Scholar 

  • Kalivas PW (2008) Addiction as a pathology in prefrontal cortical regulation of corticostriatal circuitry.Neurotox. Res. 14, 175–180.

    Google Scholar 

  • Kalivas PW and C O’Brien (2008) Drug addiction as a pathology of staged neuroplasticity.Neuropsychopharmacol. Rev. 33, 166–180.

    Article  CAS  Google Scholar 

  • Kalivas PW, ND Volkow and J Seamans (2005) Unmanageable moyivation in addiction: a pathology in prefrontal-accumbens glutamate transmission.Neuron 45, 647–650.

    Article  PubMed  CAS  Google Scholar 

  • Karlsson E and T Archer (2007) Relationship between personality characteristics and affect: gender and affective personality.Individ. Diff. Res. 5, 44–58.

    Google Scholar 

  • Karlsson E and T Archer (2008) Affective state, stress and Type A-personality as a function of gender and affective personality.Soc. Behav. Personality 36.

  • Katzmarzyk PT, I Janssen and CI Ardern (2003) Physical inactivity, excess adiposity and premature mortality.Obesity Rev. 4, 257–290.

    Article  CAS  Google Scholar 

  • Kawachi I, D Sparrow, LD Kubzansky, A Spiro, PS Vokonas and ST Weiss (1998) Prospective study of a self-report Type A scale and risk of coronary heart disease. Test of the MMPI-2 Type A scale.Circulation 98, 405–412.

    PubMed  CAS  Google Scholar 

  • Kendler KS, JW Kuhn, J Vittum, CA Prescott and B Riley (2005) The interaction of stressful life events and a serotonin transporter polymorphism in the prediction of episodes of major depression: a replication.Arch. Gen. Psychiatry 62, 529–535.

    Article  PubMed  CAS  Google Scholar 

  • Killcross S and E Coutureau (2003) Coordination of actions and habits in the medial prefrontal cortex of rats.Cereb. Cortex 13, 400–408.

    Article  PubMed  Google Scholar 

  • Kjellberg A and S Iwanowski (1989)Stress/Energi-formuläret: utveckling av en metod för skattning av sinnestämning i arbetet [Stress/Energy-questionnaire: development of a method for estimation of mood in worklife]. Solna, Arbetsmilj öinstitutet.

  • Koob G (1982) The dopamine anhedonia hypothesis: a pharmacological phrenology.Behav. Brain Sci. 5, 63–64.

    Google Scholar 

  • Kruger S, D Seminowicz, K Goldapple, SH Kennedy and HS Mayberg (2003) State and trait influences on mood regulation in bipolar disorder: blood flow differences with an acute mood challenge.Biol. Psychiatry 54, 1274–1283.

    Article  PubMed  Google Scholar 

  • Kruger S, M Alda, T Young, K Goldapple, S Parikh and HS Mayberg (2006) Risk and resilience markers in bipolar dis order: brain responses to emotional challenge in bipolar patients and their healthy siblings.Am. J. Psychiatry 163, 257–264.

    Article  PubMed  Google Scholar 

  • Lagopoulos J, B Ivanovski and GS Malhi (2007) An eventrelated functional MRI study of working memory in euthymic bipolar disorder.J. Psychiatr. Neurosci. 32, 174–184.

    Google Scholar 

  • Lawrence N, A Williams, S Surguladze, MJ Brammer, SCR Williams and ML Phillips (2004) Subcortical and ventral prefrontal cortical neural responses to facial expressions distinguish patients with bipolar and major depression.Biol. Psychiatry 55, 578–587.

    Article  PubMed  Google Scholar 

  • Lejoyeux M, M Arbaretaz, M McLoughlin and J Ades (2002) Impulse control disorders and depression.J. Nerv. Ment. Dis. 190, 310–314.

    Article  PubMed  Google Scholar 

  • Leong IY, MJ Farrell, RD Helme and SJ Gibson (2007) The relationship between medical comorbidity and self-rated pain, mood disturbance and function in older people with chronic pain.J. Gerontol. A Biol. Med. Sci. 62, 550–555.

    Google Scholar 

  • Lepore M and KBJ Franklin (1992) Modelling drug kinetics with brain stimulation: dopamine antagonists increase self-stimulation.Pharmacol. Biochem. Behav. 41, 489–496.

    Article  PubMed  CAS  Google Scholar 

  • Leventhal AM, AJ Waters, S Boyd, ET Moolchan, S J Heishman, C Lerman and WB Pickworth (2007) Associations between Cloninger’s temperament dimensions and acute tobacco withdrawal.Addict. Behav. 32, 2976–2989.

    Article  PubMed  Google Scholar 

  • Lewis BA, BH Marcus, RR Pate and AL Dunn (2002) Psychosocial mediators of physical activity behaviour among adults and children.Am. J. Prev. Med. 23 (Suppl. 1), 26–35.

    Article  PubMed  Google Scholar 

  • Liebman J (1982) Understanding neuroleptics: from “anhedonia” to “neuroleptothesia”.Behav. Brain Sci. 5, 64–65.

    Google Scholar 

  • Loftus ST, JL Garno, J Jaeger and AK Malhotra (2008) Temperament and character dimensions in bipolar I disorder: a comparison to healthy controls.J. Psychiatr. Res. 42, 1131–1136.

    Article  PubMed  Google Scholar 

  • Lopez-Ibor JJ (2002) The classification of stress related disorders in ICD-10 and DSM-IV.Psychopathol. 35, 107–111.

    Article  Google Scholar 

  • Macri S, W Adriani, F Chiarotti and G Laviola (2002) Risk-taking during exploration of a plus-maze is greater in adolescent than in juvenile or adult mice.Anim. Behav. 64, 541–546.

    Article  Google Scholar 

  • Maggs JL, DM Almeida and NL Galambos (1995) Risky business: the paradoxical meaning of problem behavior for young adolescents.J. Early Adolesc. 15, 344–362.

    Article  Google Scholar 

  • Malhi GS, J Lagopoulos, PS Sachdev, B Ivanovski and R Shnier (2005) An emotional Stroop functional MRI study of euthymic bipolar disorder.Bipolar Disord. 7 (Suppl. 5), 58–69.

    Article  PubMed  Google Scholar 

  • Malhi GS, J Lagopoulos, AM Owen, B Ivanovski, R Shnier and PS Sachdev (2007) Reduced activation in implicit affect induction in euthymic bipolar patients: an fMRI study.J. Affect. Disord. 97, 109–122.

    Article  PubMed  Google Scholar 

  • Manning JS (2003) Bipolar disorder in primary care.J. Fam. Pract. 3, S6-S9.

    Google Scholar 

  • Maser JD, HS Akiskal, P Schettler, W Schefter, T Moeller, J Endicott, D Solomon and P Clayton (2002) Can temperament identify affectively ill patients who engage in lethal or near-lethal suicidal behavior? A 14-year prospective study.Suicide Life-Threat. Behav. 32, 10–32.

    Article  PubMed  Google Scholar 

  • Mathé AA, and SH Gruber (2004) Neuropeptide Y has marked antidepressant properties in a rat model of depression.Neuropsychopharmacol. 29 (Suppl. 1), 154.

    Google Scholar 

  • Mathé AA, H Husum, A El Khoury, PA Jimenez-Vasquez, SHM Gruber, G Wörtwein, G Nikisch, P Baumann, H Ågren, W Andersson, A Södergren and F Angelucci (2007) Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role?Physiol. Behav. 92, 226–231.

    Article  PubMed  CAS  Google Scholar 

  • Mathé AA, A El Khoury, SHM Gruber, H Husum, G Wörtwein and C Arlinde (2009) Adult brain and behavioural effects of early life maternal deprivation, In:Beyond Neuropsychiatric Diagnostics: Symptoms Not Diagnostics (Palomo T, RJ Beninger, RM Kostrzewa and T Archer (Fundacion Cerebro y Mente:Madris, Spain) (in press).

  • McAuley E, GJ Jerome, S Elavsky, DX Marquez and SN Ramsey (2003a) Predicting long-term maintainence of physical activity in older adults.Prev. Med. 37, 110–118.

    Article  PubMed  Google Scholar 

  • McAuley E, GJ Jerome, DX Marquez, S Elavsky and B Blissmer (2003b) Exercise self-efficacy in older adults: social affective and behavioural influences.Ann. Behav. Med. 25, 1–12.

    Article  PubMed  Google Scholar 

  • McGinnis JM and WH Foege (1993) Actual causes of death in the United States.JAMA 270, 2207–2212.

    Article  PubMed  CAS  Google Scholar 

  • Meseguer V, MJ Romero, A Barros-Loscertales, V Belloch, F Bosh-Morell, J Romero and C Avila (2007) Mapping the appetitive and aversive systems with emotional pictures using a Block-design fMRI procedure.Psicothema 19, 483–488.

    PubMed  Google Scholar 

  • Millet P (2005) Locus of control and its relation to working life: studies from the fields of vocational rehabilitation and small firms in Sweden. Doctoral Dissertation, Arbetslivsinstitutet [Work life Institute], Luleå Technical University, Luleå, Sweden.

    Google Scholar 

  • Millet P and K Sandberg (2003) Locus of control and its relationship with rehabilitation outcomes of unemployed sick leavers in Sweden.J. Vocation. Rehab. 19, 59–66.

    Google Scholar 

  • Mitchell DGV, E Colledge, A Leonard and RJR Blair (2002) Risky decisions and response reversal: is there evidence of orbitofrontal dysfunction in psychopathic individuals.Neuropsychologia 40, 2013–2022.

    Article  PubMed  CAS  Google Scholar 

  • Moeller FG, ES Barratt, DM Dougherty, JM Schmitz and AC Swann (2001) Psychiatric aspects of impulsivity.Am. J. Psychiatry 158, 1783–1793.

    Article  PubMed  CAS  Google Scholar 

  • Moeller FG, DM Dougherty, ES Barratt, V Oderinde, C Mathias, HR Andrew and AC Swann (2002) Increased impulsivity in cocaine dependent subjects independent of antisocial personality disorder and aggression.Drug Alcohol Depend. 68, 105–111.

    Article  PubMed  Google Scholar 

  • Murray CJL and AD Lopez (1996) The global burden of disease: a comprehensive assessment of mortality and disability from disease, injuries and risk factors in 1990 and project to 2020.Harvard School of Public Health, Cambridge, MA, on behalf of the World Health Organisation and the World Bank, Harvard University Press.

    Google Scholar 

  • Nemeroff CB, CM Heim, ME Thaseet al. (2003) Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma.Proc. Natl. Acad. Sci. USA 100, 14293–14296.

    Article  PubMed  CAS  Google Scholar 

  • Nestadt G, FC Hsu, J Samuels, OJ Bienvenu, I Reti, PT Costa and WW Eaton (2006) Latent structure of the Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, personality disorder criteria.Compr. Psychiatry 47, 54–62.

    Article  PubMed  Google Scholar 

  • Newman CL and RW Motta (2007) The effects of aerobic exercise on childhood PTSD, anxiety, and depression.Int. J. Emerg. Health 9, 133–158.

    Google Scholar 

  • Nightingale EO and B Fischhoff (2002) Adolescent risk and vulnerability: an overview.J. Adolesc. Health 31, 3–9.

    Article  PubMed  Google Scholar 

  • Nowakowska C, C Strong, C Santosa, PW Wang and T Ketter (2005) Temperamental commonalities in euthymic mood disorder patients, creative controls, and healthy controls.J. Affect. Disord. 85, 207–215.

    Article  PubMed  Google Scholar 

  • Oman RF and AC King (2000) The effect of life events and exercise program format on the adoption and maintainence of exercise behavior.Health Psychol. 19, 605–612.

    Article  PubMed  CAS  Google Scholar 

  • Otani K, A Suzuli, G Ishii, Y Matsumoto and M Kamata (2008) Relationship of interpersonal sensitivity with dimensions of the temperament and character inventory in healthy subjects.Comprehen. Psychol. 49, 184–187.

    Article  Google Scholar 

  • Overstreet DH, E Friedman, AA Mathé and G Yadid (2005) The Flinders Sensitive Line rat: a selectively bred putative animal model of depression.Neurosci. Biobehav. Rev. 29, 739–759.

    Article  PubMed  CAS  Google Scholar 

  • Palomo T, TA Archer, RJ Beninger and RM Kostrzewa (2004a) Gene-environment interplay in neurogenesis and neurodegeneration.Neurotox. Res. 6, 415–434. Review.

    PubMed  Google Scholar 

  • Palomo T, TA Archer, RM Kostrzewa and RJ Beninger (2004b) Gene-environment interplay in schizopsychotic disorders.Neurotox. Res. 6, 1–9. Review.

    PubMed  Google Scholar 

  • Palomo T, RJ Beninger, RM Kostrzewa and T Archer (2004c) Gene-environment interplay in affect and dementia: emotional modulation of cognitive expression in personal outcomes.Neurotox. Res. 6, 159–173.

    PubMed  CAS  Google Scholar 

  • Palomo T, RM Kostrzewa, RJ Beninger and TA Archer (2004d) Gene-environment interplay in alcoholism and other substance abuse disorders: expressions of heritability and factors influencing vulnerability.Neurotox. Res. 6, 343–361. Review.

    PubMed  Google Scholar 

  • Palomo T, RJ Beninger, RM Kostrzewa and T Archer (2007) Treatment consideration and manifest complexity in comorbid neuropsychiatric disorders.Neurotox. Res. 12, 43–60.

    PubMed  Google Scholar 

  • Palomo T, RJ Beninger, RM Kostrzewa and T Archer (2008) Symptom veracity and diagnostic veniality in brain dysfunction: conscious and nonconscious expression in impulsiveness and decision.Neurotox. Res. (in press)

  • Pang TYC, NC Stam, J Nithianantharajah, ML Howard and AJ Hannan (2006) Differential effects of voluntary physical exercise on behavioral and brain-derived neurotrophic factor expression deficits in Huntington’s disease transgenic mice.Neuroscience 141, 569–584.

    Article  PubMed  CAS  Google Scholar 

  • Park S, HK Yoo, JY Kim, J Jeon, SH Choi, HR Wang and T Sung Ko (2007) Temperament and character factors in Korean children with seizure disorders.J. Nerv. Ment. Disord. 195, 470–476.

    Article  Google Scholar 

  • Pate RR, M Pratt, S Blair, WL Haskell, CA Macera, C Bouchardet al. (1995) Physical activity and public health: a recommendation from the Centers for Disease Control and Prevention and the American College of Sports Medicine.JAMA 273, 402–407.

    Article  PubMed  CAS  Google Scholar 

  • Peirson AR, JW Heuchert, L Thomala, M Berk, H Plein and CR Cloninger (2000) Relationship between serotonin and the temperament and character inventory.Psychiatr. Res. 89, 29–37.

    Article  Google Scholar 

  • Pelissolo A, P Ecochard and B Falissard (2008) Psychometric characteristics of Cloninger’s criteria for personality disorder in a population of French prisoners.Int. J. Methods Psychiatr. Res. 17, 30–34.

    Article  PubMed  Google Scholar 

  • Phillips ML (2009) Neuroimaging studies of bipolar disorder: identifying disease biomarkers, In:Beyond Neuropsychiatric Diagnostics: Symptoms Not Diagnostics (Palomo T, RJ Beninger, RM Kostrzewa and T Archer (Fundacion Cerebro y Mente:Madris, Spain) (in press).

    Google Scholar 

  • Pickering AD, PJ Corr, JH Powell, V Kumari, JC Thornton and JA Gray (1997) Individual differences in reactions to reinforcing stimuli are neither black nor white: to what extent are they gray? In:The Scientific Study of Personality: Tribute to Hans J. Eysenck at Eighty (Nyborg H, Ed.) (Elsevier Sciences:London), pp 241–270.

    Google Scholar 

  • Pietropaolo S, J Feldon, E Alleva, F Cirulli and BK Yee (2006) The role of voluntary exercise in enriched rearing: a behavioural analysis.Behav. Neurosci. 120, 787–803.

    Article  PubMed  Google Scholar 

  • Piko BF and N Keresztes (2006) Physical activity, psychosocial health, and life goals among youth.J. Community Health 31, 136–145.

    Article  PubMed  Google Scholar 

  • Pitel AL, H Beaunieux, T Witkowski, F Vabret, B Guillery Girard, P Quinette, B Desgranges and F Eustache (2007) Genuine episodic memory deficits and executive dysfunctions in alcoholic subjects early in abstinence.Alcohol. Clin. Exp.Res. 31, 1169–1178.

    Article  PubMed  Google Scholar 

  • Pryce CR, D Ruedi-Bettschen, AC Dettling, A Weston, H Russig, B Ferger and J Feldon (2005) Long-term effects of early-life environment manipulations in rodents and primates: potential animal models in depression research.Neurosci. Biobehav. Rev. 29, 649–674.

    Article  PubMed  Google Scholar 

  • Rech R (1982) Neurolepsis: anhedonia or blunting of emotional reactivity.Behav. Brain Sci. 5, 72–73.

    Google Scholar 

  • Reid I, L Treliving and A Lowit (2009) Mental disorder and early life trauma: symptom profiles, In:Beyond Neuropsychiatric Diagnostics: Symptoms Not Diagnostics (Palomo T, RJ Beninger, RM Kostrzewa and T Archer (Fundacion Cerebro y Mente:Madris, Spain) (in press).

  • Reif A, M Rösler, CM Freitag, M Schneider, A Eujen, C Kissling, D Wenzler, CP Jacob, P Retz-Junginger, J Thome, KP Lesch and W Retz (2007) Nature and nurture predispose to violent behaviour: serotonergic genes and adverse childhood environment.Neuropsychopharmacol. 32, 2375–2383.

    Article  CAS  Google Scholar 

  • Rogers RD (2003) Neuropsychological investigations of the impulsive personality disorders.Psychol. Med. 33, 1335–1340.

    Article  PubMed  Google Scholar 

  • Rosenberg M (1965)Society and the Adolescent Self-Image (Princeton University Press:Princeton, NJ).

    Google Scholar 

  • Rotter JB (1966) Generalized expectancies for internal versus external Control of Locus of reinforcement.Psychol. Monogr. 80 (Whole no. 609).

  • Ruchkin VV, M Eisemann and B Hägglöf (1998) Parental rearing and problem behaviours in male delinquent adolescents versus controls in northern Russia.Soc. Psychiatry Psychiatr. Epidemiol. 33 (10), 477–482.

    Article  PubMed  CAS  Google Scholar 

  • Rutter M (2005) How the environment affects mental health.Br. J. Psychiatry 186, 4–6.

    Article  PubMed  Google Scholar 

  • Salamone JD, MS Cousins and S Bucher (1994) Anhedonia or anergia? Effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost/benefit procedure.Behav. Brain Res. 65, 221–229.

    Article  PubMed  CAS  Google Scholar 

  • Salamone JD, MS Cousins and BJ Snyder (1997) Behavioural functions of nucleus accumbens dopamine: empirical and conceptual problems with the anhedonia hypothesis.Neurosci. Biobehav. Rev. 21, 341–359.

    Article  PubMed  CAS  Google Scholar 

  • Salamone JD, M Correa, S Mingote and SM Weber (2003) Nucleus accumbens dopamine and the regulation of effort in food-seeking behaviour: implication for studies of natural motivation, psychiatry, and drug abuse.J. Pharmacol. Exp. Ther. 305, 1–8.

    Article  PubMed  CAS  Google Scholar 

  • Salamone JD, M Correa, S Mingote and SM Weber (2005) Beyond the reward hypothesis: alternative functions of nucleus accumbens dopamine.Curr. Opin. Pharmacol. 5, 34–41.

    Article  PubMed  CAS  Google Scholar 

  • Samorajski T, C Delaney, L Durham, JM Ordy, JA Johnson and WP Dunlap (1985) Effect of exercise on longevity, body weight, locomotor performance, and passive-avoidance memory of C57BL/6J mice.Neurobiol. Aging 6, 17–24.

    Article  PubMed  CAS  Google Scholar 

  • Sandborgh G and B Stening (1993)Inlärning genom Rörelse [Learning through Movement] (Berlings Arlöv:Sweden).

    Google Scholar 

  • Schmeck K and F Poustka (2001) Temperament and disruptive behavior disorders.Psychopathol. 34(3), 159–163.

    Article  CAS  Google Scholar 

  • Schmitz N, J Kruse and J Kugler (2004) The association between physical exercises and health-related quality of life in subjects with mental disorders: results from a cross-sectional survey.Prev. Med. 39, 1200–1207.

    Article  PubMed  Google Scholar 

  • Schwartz RW, JR Barclay, PI Harrell, AE Murphy, RK Jarecky and MB Donnelly (1994) Defining the surgical personality: a preliminary study.Surgery 115, 62–68.

    PubMed  CAS  Google Scholar 

  • Seeman P and BK Madras (1998) Anti-hyperactivity medication with methylphenidate and amphetamine.Mol Psychiatry 3, 386–396.

    Article  PubMed  CAS  Google Scholar 

  • Seidman LJ, EM Valera and N Makris (2005) Structural brain imaging of attention-deficit/hyperactivity disorder.Biol. Psychiatry 57, 1263–1272.

    Article  PubMed  Google Scholar 

  • Sheppard L, J Senior, CH Park, R Mockenhaupt and W Chodzko-Zajko (2003) Strategic priorities for increasing physical activity among adults age 50 and older: the National Blueprint Consensus Conference Summary Board.J. Aging Phys. Activ. 11, 286–292.

    Google Scholar 

  • Simon OR, AC Swann, KE Powell LB Potter, MJ Kresnow and PW O’Carroll (2001) Characteristics of impulsive suicide attempts and attempters.Suicide Life Threat Behav. 32(1 Suppl), 49–59.

    Article  PubMed  CAS  Google Scholar 

  • Smillie LD, AD Pickering and CJ Jackson (2006) The new reinforcement sensitivity theory: implications for personality measurement.Person. Soc. Psychol. Rev. 4, 320–335.

    Article  Google Scholar 

  • Soloff PH, KG Lynch, TM Kelly, KM Malone and JJ Mann (2000) Characteristics of suicide attempts of patients with major depressive episode and borderline personality disorder: a comparative study.Am. J. Psychiatry 157, 601–608.

    Article  PubMed  CAS  Google Scholar 

  • Southwick SM, M Vythilingam and DS Charney (2005) The psychobiology of depression and resilience to stress: implications for prevention and treatment.Annu. Rev. Clin. Psychol. 1, 255–291.

    Article  PubMed  Google Scholar 

  • Stadler C, D Grasmann, JM Fegert, M Holtmann, F Poustka and K Schmeck (2008) Heart rate and treatment effect in children with disruptive behavior disorders.Child. Psychiatr. Hum. Dev. 39, 299–309.

    Article  Google Scholar 

  • Stanford MS and ES Barratt (1992) Impulsivity and the multi-impulsive personality disorder.Pers. Individ. Differ. 13, 831–834.

    Article  Google Scholar 

  • Starkweather AR (2007) The effects of exercise on perceived stress and IL-6 levels among older adults.Biol. Res. Nurs. 8, 186–194.

    Article  PubMed  CAS  Google Scholar 

  • Stroth S, K Hille, M Spitzer and R Reinhardt (2008) Aerobic endurance exercise benefits memory and affect in young adults.Neuropsychol. Rehabil. 5, 1–7.

    Google Scholar 

  • Svrakic DM, C Whitehead, TR Pryzbeck and CR Cloninger (1993) Differential diagnosis of personality disorders by the seven factor model of temperament and character.Arch. Gen. Psychiatry 50, 991–999.

    PubMed  CAS  Google Scholar 

  • Swann AC (2006) What is bipolar disorder?Am. J. Psychiatry 163, 177–179.

    Article  PubMed  Google Scholar 

  • Swann AC, DM Dougherty, PJ Pazzaglia, M Pham and FG Moeller (2004) Impulsivity: a link between bipolar disorder and substance abuse.Bipolar Disord. 6, 204–212.

    Article  PubMed  Google Scholar 

  • Swann AC, DM Dougherty, PJ Pazzaglia, M Pham, JL Steinberg and FG Moeller (2005) Increased impulsivity associated with severity of suicide attempt history in patients with bipolar disorder.Am. J. Psychiatry 162, 1680–1687.

    Article  PubMed  Google Scholar 

  • Swann AC, FG Moeller, JL Steinberg, L Schneider, ES Barratt and DM Dougherty (2007) Manic symptoms and impulsivity during bipolar depressive episodes.Bipolar Disord. 9, 206–212.

    Article  PubMed  Google Scholar 

  • Swann AC, JL Steinberg, M Lijffijt and FG Moeller (2008) Impulsivity: differential relationship to depression and mania in bipolar disorder.J. Affect. Disord. 106, 241–248.

    Article  PubMed  Google Scholar 

  • Trull T and C Durrett (2005) Categorical and dimensional models of personality disorder.Ann. Rev. Clin. Psychol. 1, 355–380.

    Article  Google Scholar 

  • Van der Borght K, F Ferrari, K Klauke, V Roman, R Havekes, A Sgoifo et al (2006) Hippocampal cell proliferation across the day: increase by running wheel activity, but no effect of sleep and wakefulness.Behav. Brain Res. 167, 36–41.

    Article  PubMed  CAS  Google Scholar 

  • Van der Borght K, R Havekes, T Bos, BJL Eggen and EA Van der Zee (2007) Exercise improves memory acquisition and retrieval in the Y-maze task: relationship with hippocampal neurogenesis.Behav. Neurosci. 121, 324–334.

    Article  PubMed  Google Scholar 

  • Van Hoomissen JD, PV Holmes, AS Zellner, A Poudevigne and RK Dishman (2004) Effects of beta-adrenoceptor blockade during chronic exercise on contextual fear conditioning and mRNA for galanin and brain-derived neurotrophic factor.Behav. Neurosci. 118, 1378–1390.

    Article  PubMed  CAS  Google Scholar 

  • Van Praag H, G Kempermann and FH Gage (1999) Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus.Nat. Neurosci. 2, 266–270.

    Article  PubMed  Google Scholar 

  • Van Praag H, G Kempermann and FH Gage (2000) Neural consequences of environmental enrichment.Nat. Rev. Neurosci. 1, 191–198.

    Article  PubMed  CAS  Google Scholar 

  • Van Praag H, T Shubert, C Zhao and FH Gage (2005) Exercise enhances learning and hippocampal neurogenesis in aged mice.J. Neurosci. 25, 8680–8685.

    Article  PubMed  CAS  Google Scholar 

  • Vaynman S, Z Ying and F Gomez-Pinilla (2004) Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition.Eur. J. Neurosci. 20, 2580–2590.

    Article  PubMed  Google Scholar 

  • Wessa M, J Houenou, ML Paillere-Martinotet al. (2007) Frontostriatal overactivation in euthymic bipolar patients during an emotional go/no go task.Am. J. Psychiatry 164, 638–646.

    Article  PubMed  Google Scholar 

  • Widiger TA and DB Samuel (2005) Diagnostic categories or dimensions? A question for the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition.J. Abnorm. Psychol. 114, 494–504.

    Article  PubMed  Google Scholar 

  • Wilbur J, PJ Chandler, B Dancy and H Lee (2003) Correlates of physical activity in urban Midwestern African-American women.Am. J. Prev. Med. 25 (Suppl. 1), 45–52.

    Article  PubMed  Google Scholar 

  • Wills TA, D Vaccaro and G McNamara (1994) Novelty seeking, risk taking and related constructs as predictors of adolescent substance use: an application of Cloninger’s theory.J. Subst. Abuse 6, 1–20.

    Article  PubMed  CAS  Google Scholar 

  • Wise RA (1978) Catecholamine theories of reward: a critical review.Brain Res. 152, 215–247.

    Article  PubMed  CAS  Google Scholar 

  • Wise RA (1982) Neuroleptics and operant behavior: the anhedonia hypothesis.Behav. Brain Sci. 5, 39–87.

    Google Scholar 

  • Wise RA (1985) The anhedonia hypothesis: Mark III.Behav. Brain Sci. 8, 178–186.

    Article  Google Scholar 

  • Wise RA (1990) Drugs against pleasure.Curr. Contents 22, 20.

    Google Scholar 

  • Wise RA (2002) Brain reward circuitry: insights from unsensed incentives.Neuron 36, 229–240.

    Article  PubMed  CAS  Google Scholar 

  • Wise RA (2004) Dopamine, learning and motivation.Nat. Rev. Neurosci. 5, 483–494.

    Article  PubMed  CAS  Google Scholar 

  • Wise RA (2008) Dopamine and reward: the anhedonia hypothesis 30 years on.Neurotox. Res. 14, 169–173.

    Article  PubMed  Google Scholar 

  • Wise RA, J Spindler, H de Wit and GJ Gerber (1978) Neurolepticinduced “anhedonia“ in rats: pimozide blocks reward quality of food.Science 201, 262–264.

    Article  PubMed  CAS  Google Scholar 

  • Wörtwein G, H Husum, W Andersson, TG Bolwig and AA Mathé (2006) Effects of maternal separation on neuropeptide Y and calcitonin gene-related peptide in “depressed“ Flinders Sensitive Line rats: a study of gene-environment interactions.Prog Neuropsychopharmacol Biol. Psychiatry 30, 684–693.

    Article  PubMed  CAS  Google Scholar 

  • Zalsman G, YY Huang, MA Oquendo, AK Burke, XZ Hu, DA Brent, SP Ellis, D Goldman and JJ Mann (2006) Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression.Am. J. Psychiatry 163, 1588–1593.

    Article  PubMed  Google Scholar 

  • Zigmond AS and RP Snaith, (1983) The hospital anxiety and depression scale.Acta Psychiatr. Scand. 67, 361–370.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Servicio Psiquiatrico, Hospital Universitario 12 de Octubre, 28041, Madrid

    Tomas Palomo

  2. Departments of Psychology and Psychiatry, Queen’s University, K7L 3N6, Kingston, Ontario, Canada

    Richard J. Beninger

  3. Department of Pharmacology, Quillen College of Medicine, East Tennessee State University, 37614, Johnson City, TN, USA

    Richard M. Kostrzewa

  4. Department of Psychology, University of Gothenburg, Box 500, SE-40530, Gothenburg, Sweden

    Trevor Archer

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  1. Tomas Palomo
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Palomo, T., Beninger, R.J., Kostrzewa, R.M. et al. Affective status in relation to impulsive, motor and motivational symptoms: Personality, development and physical exercise. neurotox res 14, 151–168 (2008). https://doi.org/10.1007/BF03033807

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