Skip to main content
Log in

Mixed Germ Cell Tumor of the Ovary with Sarcomatous Component

  • Case Report
  • Published:
Pathology Oncology Research

Abstract

Germ cell tumors constitute a very complicated group of tumors of the ovary and their histogenesis is not yet clarified. Besides their histological heterogeneity, sarcomatous areas have also been described. A right ovarian mass was found in a 23-year-old female, who was being treated in the hospital for miscarriage. Disseminated omental metastases were detected during abdominal laparotomy. Pathological examination of the dissected material revealed the tumor to be a mixed germ cell tumor (immature teratoma and dysgerminoma) with sarcomatous component. Areas resembling granulosa cell tumor were also encountered. This ovarian tumor with many different histopathological features is presented with a review of the literature. The importance of thorough sampling in determining the type and extent of the malignant components is also emphasized due to their direct relation with the prognosis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Ahmed T, Bosl GJ, Hadju S: Teratoma with malignant transformation in germ cell tumors in men. Cancer 56:860–863, 1985.

    Article  PubMed  CAS  Google Scholar 

  2. Akhtar M, Bakri Y, Rank F: Dysgerminoma of the ovary with rhabdomyosarcoma. Cancer 64:2309–2312, 1989.

    Article  PubMed  CAS  Google Scholar 

  3. Bolen JW: Mixed germ cell-sex cord stromal tumor. Am J Clin Pathol 75:565–573, 1981.

    PubMed  CAS  Google Scholar 

  4. Kurman RJ, Morris HJ: Malignant mixed germ cell tumors of the ovary. A clinical and pathologic analysis of 30 cases. Obstet Gynecol 48:579–589, 1976.

    PubMed  CAS  Google Scholar 

  5. Mostofi FK, Sabin LH: Histological typing of testis tumors. Geneva, WHO 1977.

    Google Scholar 

  6. Nogales F: Germ cell tumors of the ovary, In: Obstetrical and Gynaecological Pathology. (Eds: Fox H and Wells M): 4th ed, Churchill Livingstone, New York, 1995, pp 847–896.

    Google Scholar 

  7. Radford DM, Johnson FE, Janney CG: Sarcomatous change in a teratoma after treatment of testicular carcinoma. Cancer 68:395–399, 1991.

    Article  PubMed  CAS  Google Scholar 

  8. Rishi M, Howard LN, Bratthauer GL, Tavassoli FA: Use of monoclonal antibody against human inhibin as a marker for sex cord-stromal tumors of the ovary. Am J Surg Pathol 2185:583–589, 1997.

    Article  Google Scholar 

  9. Talerman A: Germ cell tumors of the ovary. In Blaustein’s Pathology of the Female Genital Tract. (Ed: Kurman RJ), 4th ed, Springer-Verlag, New York 1994, pp 849–914.

    Google Scholar 

  10. Terrier-Lacombe MJ, Martinez-Madrigal F, Porta W, et al: Embryonal rhabdomyosarcoma arising in a mature teratoma of the testis: a case report. J Urol 143:1232–1234, 1990.

    PubMed  CAS  Google Scholar 

  11. Ulbright TM: Germ cell Neoplasms of the testis. Am J Surg Pathol 17:1075–1091, 1993.

    Article  PubMed  CAS  Google Scholar 

  12. Ulbright TM, Clark SA, Einhorn LH: Angiosarcoma associated with germ cell tumors. Hum Pathol 16:268–272, 1985.

    Article  PubMed  CAS  Google Scholar 

  13. Ulbright TM, Loehrer PJ, Roth LM, et.al: The development of non-germ cell malignancies within germ cell tumors. A clinicopathologic study of 11 cases. Cancer 54:1824–1833, 1984.

    Article  PubMed  CAS  Google Scholar 

  14. Yamashita K, Yamoto M, Shikone T, et al: Production of inhibin A and inhibin B in human ovarian sex cord stromal tumors. Am J Obstet Gynecol 177: 1450–1457, 1997.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Fevziye Kabukcuoglu.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kabukcuoglu, F., Sungun, A., Sentürk, B.A. et al. Mixed Germ Cell Tumor of the Ovary with Sarcomatous Component. Pathol. Oncol. Res. 7, 60–62 (2001). https://doi.org/10.1007/BF03032607

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03032607

Keywords

Navigation