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Recurrent pneumococcal meningitis in homozygous c3 deficiency

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Abstract

Congenital deficiencies of complement system proteins are rare. A 4-year-old girl was admitted for meningitis. She had had repeated attacks of pneumococcal meningitis and otitis media at the age of 3 years. Analysis of cerebrospinal fluid showed that this meningitis was due to pneumococcal infection. Complement 3 and CH50 values of the proband and her brother were low, while her parents were normal. The patient was given polyvalent pneumococcal and anti-haemophilus vaccines plus ceftriaxone. Recovery was complete after 15 days of antibiotic therapy. This is the first description of a case of recurrent meningitis with C3 and CH50 deficiency in a Turkish family

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Authors and Affiliations

  1. Department of Pediatrics, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey

    Mehmet Totan

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  1. Mehmet Totan
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Correspondence to Mehmet Totan.

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Totan, M. Recurrent pneumococcal meningitis in homozygous c3 deficiency. Indian J Pediatr 69, 625–626 (2002). https://doi.org/10.1007/BF02722692

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  • DOI: https://doi.org/10.1007/BF02722692

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