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Role of opioid receptors in cardioprotection of cold-restraint stress and morphine

  • Original Paper
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Journal of Biomedical Science

Abstract

Since cold exposure confers cardioprotection, the present study attempted to determine the role of opioid receptors (OR). Stress with cold exposure and restraint for 3 h, shown previously to induce peptic ulcer in a synergistic manner, attenuated infarct size induced by myocardial ischemia and reperfusion in the isolated perfused rat heart from 36.64 ± 1.8 to 22.85 ± 2.6%. This is similar to protecting the rat with morphine at 8 mg/kg, which also attenuated the infarct size from 36.26 ± 1.6 to 20.30 ± 2.1%. The effects of cold-restraint or morphine were abolished by naloxone, a non-selective OR antagonist; nor-binaltorphimine, a selective κ-OR antagonist; naltrindole, a selective δ-OR antagonist, or CTOP, a selective μ-OR antagonist. The effects were also attenuated by blockade of protein kinase C or the mitochondrial KATP channel. The finding is first evidence that all three OR subtypes mediate cardioprotection of cold-restraint stress in the rat.

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Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China

    C. H. Cho

  2. Department of Physiology, University of Hong Kong, Faculty of Medicine, 4/F, Laboratory Block, Faculty of Medicine Building 21 Sassoon Road, Hong Kong SAR, China

    S. Wu, M. C. Y. Wong, M. Chen & T. M. Wong PhD

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  2. M. C. Y. Wong
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  3. M. Chen
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  4. C. H. Cho
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  5. T. M. Wong PhD
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Wu, S., Wong, M.C.Y., Chen, M. et al. Role of opioid receptors in cardioprotection of cold-restraint stress and morphine. J Biomed Sci 11, 726–731 (2004). https://doi.org/10.1007/BF02254356

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  • DOI: https://doi.org/10.1007/BF02254356

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