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Hepatic alcohol dehydrogenase in alcoholic addicts with and without hepatic damage

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Summary

Hepatic alcohol dehydrogenase was measured in liver homogenates from normal, moderate drinkers, and from alcoholics with normal livers, steatosis, and liver cirrhosis.

Hepatic alcohol-dehydrogenase activity was 0.37±0.12 µM/hr./mg. of protein in the normals, 0.18±0.13 µM/hr/mg. in alcoholics with normal liver histology, 0.12±0.09 µM/hr./mg. in alcoholics with fatty liver, and 0.12±0.08 µM/hr./mg. in patients with alcoholic cirrhosis. Alcohol dehydrogenase was significantly lower among alcoholics. There was no difference in the activity of this enzyme between alcoholic patients with liver damage and those without liver damage.

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Authors and Affiliations

  1. From the University of Chile, Santiago, Chile

    G. Ugarte M.D., M. E. Pino & I. Insunza M.D.

Authors
  1. G. Ugarte M.D.
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  2. M. E. Pino
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  3. I. Insunza M.D.
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Additional information

This research was supported by the Faculty of Medicine, University of Chile (Grant 651-16) , and by PAHO grant under joint program.

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Ugarte, G., Pino, M.E. & Insunza, I. Hepatic alcohol dehydrogenase in alcoholic addicts with and without hepatic damage. Digest Dis Sci 12, 589–592 (1967). https://doi.org/10.1007/BF02233496

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  • DOI: https://doi.org/10.1007/BF02233496

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