Summary
The findings discussed in this paper mainly derived from studies on salivary glands, serving as model organs, indicate that the capacity to form the neurotransmitter acetylcholine, as judged by the activity of choline acetyltransferase, is influenced by the traffic of nerve impulses, as a long term effect. In the glands, choline acetyltransferase seems to be exclusively localized to the cholinergic nerves. In the postganglionic parasympathetic nerves of the glands, the activity of choline acetyltransferase decreases when the flow of secretory impulses in these nerves is abolished or reduced either by isolating the nerves from the central nervous system, surgically or pharmacologically, or by diminishing the reflex activation of the glands from the mouth. The opposite occurs when the reflex activation of the salivary glands is enhanced, i.e. the activity of choline acetyltransferase increases. Observations on various other organs are quoted in support of the view that the traffic of nerve impulses is of importance for the activity of the enzyme. An increase, in choline acetyltransferase activity also occurs in some salivary glands after sympathetic denervation. This puzzling observation is discussed in relation to impulse traffic. Increased nerve impulse traffic and collateral sprouting seem to be responsible for the rapid restitution of choline acetyltransferase activity from a low level in an organ partially deprived of its cholinergic nerve supply.
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References
C. O. Hebb and G. M. H., Waites, J. Physiol.132, 667 (1956).
C. O. Hebb and A. Silver, Nature189, 122 (1961).
C. O. Hebb, K. Krnjević and A. Silver, J. Physiol.171, 504 (1964).
C. O. Hebb, Physiol. Rev.52, 918 (1972).
J. Ekström and N. Emmelin, J. Physiol.216, 247 (1971).
F. Fonnum, M. Frizell and J. Sjöstrand, J. Neurochem.21, 1109 (1973).
S. Tuček, Brain Res.86, 259 (1975).
C. Jablecki and S. Brimijoin, J. Neurochem.25, 583 (1975).
I. Nordenfelt, Acta univ. lund. sectio II,16, 1 (1964).
N. Emmelin, Experientia21, 57 (1965).
I. Nordenfelt, Q. Jl exp. Physiol.48, 67 (1963).
C. Hebb and A. Silver, in: Neuropathology: Methods and Diagnosis, p. 665. Ed. C. G. Tedeschi, Little, Brown and Co., Boston 1970.
F. Welsch, J. Biochem. Pharmac.26, 1281 (1977).
H. Banns, J. Ekström and S. P. Mann, to be published.
J. J. Butler, D. B. Drachman and A. M. Goldberg, J. Physiol.274, 539 (1978).
E. Strack and K. Försterling, Arch. exp. Path. Pharmak.185, 612 (1937).
W.-D. Thomitzek and E. Strack, Acta biol. med. german.13, 447 (1964).
C. Hebb and D. Morris, in: The Structure and Function of Nervous Tissue, p. 25, Ed. G. H. Bourne, Academic Press, New York, London 1969.
I. Nordenfelt, Acta univ. lund. sectio II,9, 1 (1964).
J. Ekström, Q. Jl exp. Physiol.59, 191 (1974).
J. Ekström and N. Emmelin, Q. Jl exp. Physiol.59, 11 (1974).
J. Ekström and J. Holmberg, Acta physiol. scand.86, 353 (1972).
I. Nordenfelt, Q. Jl. exp. Physiol.50, 57 (1965).
I. Nordenfelt, Acta univ. lund. sectio II,10, 1 (1964).
J. Ekström, Acta physiol. scand.86, 539 (1972).
J. Holmberg, J. Physiol.219, 463 (1971).
P. Alm and J. Ekström, Q. Jl exp. Physiol.61, 127 (1976).
P. Alm and J. Ekström, Archs oral Biol.21, 417 (1976).
J. R. Garrett, Jl R. microsc. Soc.86, 1 (1966).
J. R. Garrett and J. Holmberg, Z. Zellf mikrosk. Anat.131, 451 (1972).
I. Nordenfelt, Q. Jl exp. Physiol.49, 103 (1964).
N. Emmelin, I. Nordenfelt and C. Perec, Experientia22, 725 (1966).
J. N. Langley, in: Textbook of Physiology, vol. 1, p. 482, Ed. E. A. Schäfer, Edingburg & London, Pentland 1898.
J. Lichtman, J. Physiol.273, 155 (1977).
S. Tuček, Exp. Neurol.40, 23 (1973).
J. Rossier, Int. Rev. Neurobiol.20, 283 (1977).
H. L. White and J. C. Wu, Biochemistry12, 841 (1973).
I. Nordenfelt, Q. Jl exp. Physiol.50, 62 (1965).
J. Holmberg, unpublished observations.
J. Ekström and J. Holmberg, J. Physiol.222, 93P (1972).
J. Ekström and B. Lindmark, J. Physiol.271, 31P (1977).
J. Ekström and B. Lindmark, Acta pharmac. tox. in press.
J. Ekström, Acta physiol. scand.102, 116 (1978).
J. Ekström, S. K. Kemplay, J. R. Garrett and L. W. Duchen, Experientia33, 1458 (1977).
D. B. Drachman, in: Neuropoisons, p. 325. Ed. L. L. Simpson. Plenum Press, New York, London 1971.
N. Ambache, J. Physiol.113, 1 (1951).
S. M. Hilton and G. P. Lewis, J. Physiol.128, 235 (1955).
D. A. Tonge, T. J. Gradidge and R. M. Marchbanks, J. Neurochem.,25, 329 (1975).
J. Ekström, Q. Jl exp. Physiol.58, 171 (1973).
J. Ekström, Acta physiol. scand.99, 110 (1977).
D. H. Snyder, D. H. Riefenberick and S. R. Max, Exp. Neurol.40, 36 (1973).
S. Tuček, D. K. Koštiřová and E. Gutmann, J. neurol. Sci.27, 363 (1976).
I. Diamond, G. M. Franklin and D. Milfay, J. Physiol.236, 247 (1974).
J. Ekström, Acta physiol. scand.93, 525 (1975).
J. Ekström, Acta physiol. scand.99, 48 (1977).
J. Ekström, Acta physiol. scand.92, 272 (1974).
J. Ekström and D. Templeton, Acta physiol. scand.101, 329, (1977).
J. Ekström, Acta physiol. scand.98, 185 (1976).
J. Ekström, Q. Jl exp. Physiol.59, 73 (1974).
G. J. Maletta and P. S. Timiras, J. Neurochem.15, 787 (1968).
E. Gutmann, S. Tuček and V. Hanzlíková, Physiol. bohemoslov.18, 195 (1969).
S. Tuček, D. K. Kôstiřová and E. Gutmann, J. neurol. Sci.27, 353 (1976).
A. M. Goldberg and B. L. Welch, Science178, 219 (1972).
A. J. Mandell and S. Knapp, Neuropharmacology10, 513 (1971).
F. Oesch, J. Pharmac. exp. Ther.188, 439 (1974).
F. C. MacIntosh and B. Collier, in: Handbook, of Experimental Pharmacology, vol. 42, p. 99, Ed. G. V. R. Born, O. Eichler, A. Farah, H. Herken and A. D. Welch. Springer Verlag, Berlin 1976.
I. A. Hendry, Brain Res.107, 105 (1976).
J. Ekström, Acta pharmac. tox.36, 284 (1975).
H. Thoenen and J. P. Tranzer, A. Rev. Pharmac.13, 169 (1973).
D. E. Donald, Circulation Res.34, 417 (1974).
P. Alm and M. Elmér, Acta physiol. scand.94, 36 (1975).
P. Alm and J. Ekström, Experientia33, 523 (1977).
K.-A. Norberg and L. Olson, Z. Zellforsch.68, 183, (1965).
P. Ohlin, Q. Jl exp. Physiol.53, 19 (1968).
J. Ekström, unpublished observations.
N. Assarson and N. Emmelin, Br. J. Pharmac.22, 119 (1964).
N. Emmelin and C. Perec, Q. Jl exp. Physiol.53, 10 (1968).
J. Ekström and E. Elmér, Acta physiol. scand.101, 58 (1977).
H. Banns, J. Ekström, and S. P. Mann, Acta physiol. scand.102, 47A (1978).
J. Ekström, M. Elmér and H. Banns Acta pharmac. tox., in press.
J. Ekström and M. Elmér, to be published.
I. Nordenfelt and C. Perec, Q. Jl exp. Physiol.52, 139 (1967).
J. Ekström and N. Emmelin, Q. Jl exp. Physiol.59, 1 (1974).
M. V. Edds, Jr., Q. Rev. Biol.28, 260 (1953).
J. G. Murray and J. W. Thompson, J. Physiol.135, 133 (1957).
M. V. Edds, Jr., and W. T. Small, J. exp. Med.93, 207 (1951).
F. G. Carpenter and R. M. Rubin, J. Physiol.192, 609 (1967).
M. Elmér, Experientia31, 814 (1975).
N. Emmelin and A. Muren, Acta physiol. scand.20, 13 (1950).
J. Holmberg, Acta physiol. scand86, 115 (1972).
F. Fonnum, Norwegian Defence Research Establishment, Report No. 58. 1970.
B. Jakoubek and B. Semiginovský, Int. Rev. Neurobiol.13, 255, (1970).
R. Lasek, Int. Rev. Neurobiol.13, 289 (1970).
B. Grafstein, M. Murray and N. A. Ingoglia, Brain Res.44, 37 (1972).
L. M. Zieher and A. Pellegrino de Iraldi Life Sci.5, 155 (1966).
P. B. Molinoff and J. Axelrod, A. Rev. Biochem.40, 465 (1971).
A. Pletscher, Pharmac. Rev.24, 225 (1972).
H. Thoenen, Life Sci.14, 223 (1974).
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Ekström, J. Acetylcholine synthesis and its dependence on nervous activity. Experientia 34, 1247–1253 (1978). https://doi.org/10.1007/BF01981399
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DOI: https://doi.org/10.1007/BF01981399