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Phospholipase C-induced neural tube defects in the mouse embryo

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Summary

Mouse embryo neurulae were exposed in vitro to phospholipase C to examine the role of carbohydrate-rich extracellular material (ECM) during neurulation. Exposure of embryos to this agent for 12 h resulted in failure of closure of the neural tube. Ultrastructural examination revealed an absence of ECM from regions of the neural tube which failed to close.

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Author notes

  1. K. S. O'Shea

    Present address: Department of Anatomy, University of Nebraska Medical Center, 42nd & Dewey Avenue, 68105, Omaha, Nebraska, USA

Authors and Affiliations

  1. Department of Anatomy, Downing Street, CB2 3DY, Cambridge, England

    K. S. O'Shea & M. H. Kaufman

Authors
  1. K. S. O'Shea
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  2. M. H. Kaufman
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Additional information

This study was supported by a grant from the National Fund for Research into Crippling Diseases.

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O'Shea, K.S., Kaufman, M.H. Phospholipase C-induced neural tube defects in the mouse embryo. Experientia 36, 1217–1219 (1980). https://doi.org/10.1007/BF01976138

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  • DOI: https://doi.org/10.1007/BF01976138

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