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The biology ofPlasmodium in the mosquito

  • The Present State of Malaria Research
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References

  1. Aikawa, M., Carter, R., Ito, Y., and Nijhout, M. N., New observations on gametogenesis, fertilization and zygote transformation inPlasmodium falciparum. J. Protozool. (1983) in press.

  2. Aikawa, M., Cochrane, A. H., Nussenzweig, R. S., and Rabbege, J., Freeze-fracture study of malaria sporozoite: Antibody-induced changes of the pellicular membranes. J. Protozool.26 (1979) 273–279.

    Article  CAS  PubMed  Google Scholar 

  3. Aikawa, M., Huff, C. G., and Sprinz, H., Comparative fine structure study of the gametocytes of avian, reptilian and mammalian malarial parasites. J. Ultrastruct. Res.26 (1969) 316–331.

    Article  CAS  PubMed  Google Scholar 

  4. Aikawa, M., Rener, J., Carter, R., and Miller, L. H., An electron microscopical study of the interaction of monoclonal antibodies with gametes of the malaria parasite. J. Protozool.28 (1981) 383–388.

    Article  CAS  PubMed  Google Scholar 

  5. Alger, N. E.,In vitro development ofPlasmodium berghei ookinetes. Nature218 (1968) 774.

    Article  CAS  PubMed  Google Scholar 

  6. Al-Mashadini, H. M., Davidson, G., and Curtis, C. F., A genetic study of the susceptibility ofAnopheles gambiae inPlasmodium berghei. Trans. Roy. Soc. trop. Med. Hyg.74 (1980) 585–594.

    Article  Google Scholar 

  7. Anderson, C. W., and Cowdry, E. V., Etudes cytologiques sur le paludisme. Étude de la ‘flagellation’ duPlasmodium kochi avec le fond noir. Arch. Inst. Pasteur Tunis17 (1928) 46–72.

    Google Scholar 

  8. Baker, J. R., Nucleic acids in the ookinete ofP. cynomolgi bastianellii. Trans. Roy. Soc. trop. Med. Hyg.57 (1963) 233.

    Article  Google Scholar 

  9. Ball, G. H., In vitro culture of the mosquito phase of avian malaria. J. Parasit.50 (1964) 3–10.

    Article  CAS  PubMed  Google Scholar 

  10. Ball, G. H., and Chao, J., In vitro development of the mosquito phase ofPlasmodium relictum. Exp. Parasit.9 (1960) 47–55.

    Article  CAS  PubMed  Google Scholar 

  11. Ball, G. H., and Chao, J., Use of amino acids byPlasmodium relictum oocystsin vitro. Exp. Parasit.39 (1976) 115–118.

    Article  CAS  PubMed  Google Scholar 

  12. Bano, L., A cytological study of the early oocysts of seven species ofPlasmodium. Parasitology (1959) 559–585.

  13. Beaudoin, R. L., Strome C. P. A., and Tubergen, T. A.,Plasmodium berghei berghei: Ectopic development of the ANKA strain inAnopheles stephensi. Exp. Parasit.36 (1974) 189–201.

    Article  CAS  PubMed  Google Scholar 

  14. Bennett, G. F., Warren, Mc. W., and Cheong, W. H., Biology of the Simian malarias of Southeast Asia II. The susceptibility of some Malaysian mosquitoes to infection with five strains ofPlasmodium cynomolgi. J. Parasit.52 (1966) 625–631.

    Article  CAS  PubMed  Google Scholar 

  15. Birago, C., Bucchi, A., Dore, E., and Frontali, C., A mosquito infectivity is directly related to the proportion of repetitive DNA inPlasmodium berghei. Molec. biochem. Parasit.6 (1982) 1–12.

    Article  CAS  Google Scholar 

  16. Burkot, T. R., Zavala, F., Gwadz, R. W., Collins, F. M., Nussenzweig, R. S., and Roberts, D. R., Identification of malaria infected mosquitoes by a two-site enzyme-linked immunoadsorbent assay. Am. J. trop. Med. Hyg. (1983) in press.

  17. Canning, E. U., and Sinden, R. E., The organisation of the ookinete and observations on nuclear division in oocysts ofPlasmodium berghei. Parasitology67 (1973) 29–40.

    Article  CAS  PubMed  Google Scholar 

  18. Carter, R., personal communication.

  19. Carter, R., and Chen, D. H., Malaria transmission blocked by immunisation with gametes of the malaria parasite. Nature263 (1979) 58–60.

    Google Scholar 

  20. Carter, R., and Gwadz, R. W., Infectiousness and gamete immunisation in malaria, in: Malaria, vol. 3, pp. 263–297. Ed. J. P. Kreier. Academic Press, New York 1980.

    Chapter  Google Scholar 

  21. Carter, R., Gwadz, R. W., and Green, I.,Plasmodium gallinaceum: transmission blocking immunity in chickens. II. The effect of antigamete antibodies in vitro and in vivo and their elaboration during infection. Exp. Parasit.47 (1979) 194–202.

    Article  CAS  PubMed  Google Scholar 

  22. Chen, D. H., Preliminary study on the in vitro cultivation of ookinetes of rodent malaria parasites. Chin. J. Zool.1 (1981) 1–5.

    Google Scholar 

  23. Chen, D. H., Seeley, D., and Good, W. C., In vitroPlasmodium berghei ookinete formation. 5th Int. Congr. Protozool, 1977, Abstracts p. 21.

  24. Clements, A. N., The Physiology of Mosquitoes. Pergamon Press, Oxford 1963.

    Google Scholar 

  25. Coatney, G. R., Collins, W. E., Warren. McW., and Contactos, P. G., The Primate Malarias, U.S. Department of Health Education and Welfare. N.I.A.I.D., Bethesda, Maryland 20014, USA, 1971.

    Google Scholar 

  26. Cochrane, A. H., Aikawa, M., Jeng, M., and Nussenzweig, R. S., Antibody induced ultrastructural changes of malarial sporozoites. J. Immun.116 (1976) 859–867.

    Article  CAS  PubMed  Google Scholar 

  27. Cochrane, A. H., Santoro, F., Nussenzweig, V., Gwadz, R. W., and Nussenzweig, R. S., Monoclonal antibodies identify the protective antigens of sporozoites ofPlasmodium knowlesi. Proc. natl Acad. Sci.79 (1982) 5651–5655.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Collins, F. H., Zavala, F., Graves, P. M., Cochrane, A. H., Gwadz, R. W., Akoh, J., and Nussenzweig, R. S., First field trials of a immunoradiometric assay for the detection of malaria sporozoites in mosquitos. Am. J. trop. Med. Hyg.33 (1984) 538–543.

    Article  CAS  PubMed  Google Scholar 

  29. Curtis, C. F., and Graves, P. M., Genetic variation in the ability of insects to transmit filariae, trypanosomes and malarial parasites, in: Current Topics in Pathogen Vector Host Research. Ed. K. F. Harris (1983) in press.

  30. Daher, V. R., and Krettli, A. V., Infectivity ofPlasmodium gallinaceum sporozoite from oocysts. J. Protozool.27 (1980) 440–442.

    Article  CAS  PubMed  Google Scholar 

  31. Davies, E. E., Ultrastructural studies on the early ookinete stage ofPlasmodium berghei nigeriensis and its transformation into an oocyst. Ann. trop. Med. Parasit.68 (1974) 283–290.

    Article  CAS  PubMed  Google Scholar 

  32. Davies, E. E., Acid hydrolases of the sporogonic stage ofPlasmodium berghei nigeriensis. Ann. trop. Med. Parasit.68 (1974) 379–384.

    Article  CAS  PubMed  Google Scholar 

  33. Davies, E. E., and Howells, R. E., Uptake of3H-adenosine and3H-thymidine by oocyts ofPlasmodium berghei berghei. Trans. Roy. soc. trop. Med. Hyg.67 (1973) 20.

    Article  CAS  PubMed  Google Scholar 

  34. Dei-Cas, E., Maurois, P., Landau, I., Dutoit, E., Miltgen, F., Vernes, A., and Biguet, J., Morphologie et infectivité des gamétocytes dePlasmodium inui. Ann. Parasit.55 (1980) 621–633.

    Article  CAS  Google Scholar 

  35. Denhofer, U., Erblichkeit der Übertragungsfähigkeit bzw. Resistenz gegen Vogelmalaria bei der StechmückeCulex pipiens L.. Anz. Schädlingsk.44 (1971) 84–91.

    Google Scholar 

  36. Dore, E., Birago, C., Frontali, C., and Battaglia, P. A., Kinetic complexity and repetitivity ofPlasmodium berghei DNA. Molec. biochem. Parasit.1, 199–208.

  37. Dubremetz, J. F., and Torpier, G., Freeze-fracture study of the pellicle of an Eimerine sporozoite. J. Ultrastruct. Res.62 (1978) 94–109.

    Article  CAS  PubMed  Google Scholar 

  38. Dubremetz, J. F., Torpier, G., Maurois, P., Prensier, G., and Sinden, R. E., Structure de la pellicule du sporozoite dePlasmodium yoelii. C. r. Acad. Sci.288 (1979) 623–626.

    Google Scholar 

  39. Ellis, J., Osaki, L. S., Gwadz, R. W., Cochrane, A. H., Nussenzweig, V., Nussenzweig, R., and Godson, G. N., Cloning and expression inE. coli of the malarial sporozoite surface antigen gene fromPlasmodium knowlesi. Nature302 (1983) 536–538.

    Article  CAS  PubMed  Google Scholar 

  40. Emmel, L., Jakob, A., and Golz, H., Elektronenoptische Untersuchungen am Malaria-Sporozoiten. Dt. med. Z.46 (1942) 254–258.

    Google Scholar 

  41. Eyles, D. E., Studies onPlasmodium gallinaceum I. Characteristics of the infection in the mosquito,Aedes aegypti. Am. J. trop. Med. Hyg.54 (1951) 101–112.

    CAS  Google Scholar 

  42. Eyles, D. E., Studies onPlasmodium gallinaceum. II. Factors in the blood of the vertebrate host influencing mosquito infection. Am. J. trop. Med. Hyg.55 (1952) 276–290.

    CAS  Google Scholar 

  43. Eyles, D. E., Studies onPlasmodium gallinaceum. III. Factors associated with the malaria infection in the vertebrate host which influence the degree of infection in the mosquito. Am. J. trop. Med. Hyg.55 (1952) 386–391.

    CAS  Google Scholar 

  44. Freyvogel, T. A., Shape, movementin situ and locomotion of Plasmodial ookinetes. Acta trop.23 (1966) 201–222.

    CAS  PubMed  Google Scholar 

  45. Gad, A. M., Maier, W. A., and Piekarski, G., Pathology ofAnopheles stephensi after infection withPlasmodium berghei berghei. I. Mortality rate. Z. ParasitKde60 (1979) 249–261.

    Article  CAS  Google Scholar 

  46. Gad, A. M., Maier, W. A., and Piekarski, G., Pathology ofAnopheles stephensi after infection withPlasmodium berghei berghei. II. Changes in amino acid contents. Z. ParasitKde60 (1979) 263–275.

    Article  CAS  Google Scholar 

  47. Gajanana, A., Tewari, S. C., Reuben, R., and Rajagopalan, P. K., Partial suppression of malaria parasites inAedes aegypti andAnopheles stephensi doubly infected withNosema algerae andPlasmodium. Indian J. med. Res.70 (1979) 417–423.

    CAS  PubMed  Google Scholar 

  48. Gao, X. Z., and Yuan, G. X., Morphological observations on ookinete formation in rodentPlasmodium (Plasmodium berghei yoelii) in vitro. Acta zool. sin.27 (1981) 153–158.

    Google Scholar 

  49. Garnham, P. C. C., Factors influencing the development of protozoa in their arthropodan hosts, in: Host-Parasitic Relationships in Invertebrate Hosts, pp. 33–50. Ed. A. E. R. Taylor. Blackwell, Oxford 1964.

    Google Scholar 

  50. Garnham, P. C. C., Malaria Parasites and other Haemosporidia. Blackwell, Oxford 1966.

    Google Scholar 

  51. Garnham, P. C. C., Bird, R. G., and Baker, J. R., Electron microscope studies of the motile stages of malaria parasites. Trans. R. Soc. trop. Med. Hyg.54 (1960) 274–278.

    Article  CAS  PubMed  Google Scholar 

  52. Garnham, P. C. C., Bird, R. G., and Baker, J. R., Electron microscope studies of motile stages of malarial parasites. III. The ookinetes ofHaemamoeba andPlasmodium. Trans. R. Soc. trop. Med. Hyg.56 (1962) 116–120.

    Article  CAS  PubMed  Google Scholar 

  53. Garnham, P. C. C., Bird, R. G., Baker, J. R., Desser, S. S., and El Nahal, H. M. S., Electron microscope studies on the motile stages of malaria parasites. VI. The ookinete ofPlasmodium berghei yoelii and its transformation into the early oocyst. Trans. R. Soc. trop. Med. Hyg.63 (1969) 187–194.

    Article  CAS  PubMed  Google Scholar 

  54. Gass, R. F., Influences of blood digestion on the development ofPlasmodium gallinaceum (Brumpt) in the midgut ofAedes aegypti (L). Acta trop.34 (1977) 127–140.

    CAS  PubMed  Google Scholar 

  55. Gass, R. F., The ultrastructure of culturedPlasmodium gallinaceum ookinetes. A comparison of intact stages with forms damaged by extracts from blood fed susceptibleAedes aegypti. Acta trop.36 (1979) 323–334.

    CAS  PubMed  Google Scholar 

  56. Gass, R. F., and Yeates, R. A. In vitro damage of cultured ookinetes ofPlasmodium gallinaceum by digestive proteinases from susceptibleAedes aegypti. Acta trop.36 (1979) 243–252.

    CAS  PubMed  Google Scholar 

  57. Godson, G. N., Ellis, J., Svec, P., Schlesinger, D. H., and Nussenzweig, V., Identification and chemical synthesis of a tandemly repeated immunogenic region ofPlasmodium knowlesi circumsporozoite protein. Nature305 (1983) 29–33.

    Article  CAS  PubMed  Google Scholar 

  58. Gore, R. C., and Noblet, G. P., The effect of photoperiod on the deep body temperature of domestic turkeys and its relationship to the diurnal periodicity ofLeucocytozoon smithi gametocytes in the peripheral blood of turkeys. Poult. Sci.57 (1978) 603–607.

    Article  CAS  PubMed  Google Scholar 

  59. Gore, R. C., Noblet, G. P., and Noblet, R., Effects of pinealectomy and ocular enucleation on diurnal periodicity ofLeucocytozoon smithi (Haemosporina) gametocytes in the peripheral blood of domestic turkeys. J. Protozool.29 (1982) 415–420.

    Article  CAS  PubMed  Google Scholar 

  60. Gwadz, R. W., Malaria: Successful immunisation against the sexual stages ofPlasmodium gallinaceum. Science193 (1976) 1150–1151.

    Article  CAS  PubMed  Google Scholar 

  61. Gwadz, R. W., Koontz, L. C., Miller, L. H., and Davidson, D. E. Jr,Plasmodium gallinaceum: avian screen for drugs with radical curative properties. Exp. Parasit.55 (1983) 188–196.

    Article  CAS  PubMed  Google Scholar 

  62. Hawking, F., Wilson, M. E., and Gammage, K., Evidence for cyclic development and short lived maturity in the gametocytes ofPlasmodium falciparum. Trans. R. Soc. trop. Med. Hyg.65 (1971) 549–559.

    Article  CAS  PubMed  Google Scholar 

  63. Hecker, H., Intracellular distribution of ribosomes in midgut cells of the malaria mosquitoAnopheles stephensi (Liston) (Insecta: Diptera) in response to feeding. Int. J. Insect Morphol. Ent.7 (1978) 267–272.

    Article  Google Scholar 

  64. Heidrich, H. C., Danforth, H. D., and Beaudoin, R. L., Free-flow electrophoresis isolation of whole bodyPlasmodium berghei sporozoites, in: Electrophoresis '81, pp. 866–870. Eds R. C. Allen and P. Arnaud. de Gruyter, Berlin/New York 1981.

    Google Scholar 

  65. Hilton, D. F. J., Resistance and susceptibility of some strains of theAnopheles gambiae complex to infections withPlasmodium spp. of rodents. Mosquito News34 (1974) 81–85.

    Google Scholar 

  66. Howells, R. E., Mitochondrial changes during the life cycle ofPlasmodium berghei. Ann. trop. Med. Parasit.64 (1970) 181–187.

    Article  CAS  PubMed  Google Scholar 

  67. Howells, R. E., and Davies, E. E., Nuclear division in the oocyst ofPlasmodium berghei. Ann. trop. Med. Parasit.65 (1971) 451–459.

    Article  CAS  PubMed  Google Scholar 

  68. Huff, G. G., Individual immunity and susceptibility ofCulex pipiens to various species of bird malaria as studied by means of double infectious feeding. Am. J. Hyg.12 (1930) 424–441.

    Google Scholar 

  69. Huff, G. G., The inheritance of natural immunity ofP. cathemerium in two species ofCulex. J. prev. Med.8 (1931) 249–259.

    Google Scholar 

  70. Huff, G. G., Comparative studies on susceptible and insusceptibleCulex pipiens in relation to infections withPlasmodium cathemerium andP. relictum. Am. J. Hyg.19 (1934) 123–147.

    Google Scholar 

  71. Hulls, R. H., The adverse effects of a microsporidian on sporogony and infectivity ofPlasmodium berghei. Trans. R. Soc. trop. Med. Hyg.65 (1971) 421.

    Article  CAS  PubMed  Google Scholar 

  72. Kaay, H. J., van der, and Boorsma, L., A susceptible and refractive strain ofAnopheles atroparvus van Thiel to infection withPlasmodium berghei berghei. Acta leidensia45 (1977) 13–19.

    PubMed  Google Scholar 

  73. Kaay, H. J., van der, Noordink, J. P. W., and Boorsma, L., Labelling ofPlasmodium berghei during sporogony. Acta leidensia45 (1977) 7–12.

    PubMed  Google Scholar 

  74. Kaay, H. J., van der, Sikkema, A. C. L., and Boorsma, E. G., Observations on the development ofPlasmodium berghei berghei (ANKA) in a susceptible and a refractory strain ofAnopheles atroparvus. van Thiel. Parasitology77 (1979) 47.

    Google Scholar 

  75. Kaushal, D. C., Carter, R., Howard, R., and McAuliff, F. M., Characterisation of antigens of mosquito midgut stages ofPlasmodium gallinaceum. I. Zygote surface antigens. J. molec. biochem. Parasit.8 (1983) 53–69.

    Article  CAS  Google Scholar 

  76. Kilama, W. L., and Craig, G. B., Monofactorial inheritance of susceptibility toPlasmodium gallinaceum inAedes aegypti. Ann. trop. Med. Parasit.63 (1969) 419–432.

    Article  CAS  PubMed  Google Scholar 

  77. Krotoski, W. A., Omar, M. S., and Jumper, J. R., Immunofluorescent staining of plasmodial, oocysts in the mosquito. J. Parasit.60 (1974) 344–347.

    Article  CAS  PubMed  Google Scholar 

  78. Kumar, N., Grotendorst, C. A., and Carter, R., Biosynthesis of antigens on the surface of the transforming zygote and mature ookinete ofPlasmodium gallinaceum. 2nd Int. Conf. Malaria and Babesiosis 1983; abstracts, p. 136.

  79. Landau, I., Miltgen, F., Boulard, Y., Chabaud, A-G., and Baccam, D., Etudes sur des gamétocytes desPlasmodium du groupe ‘vivax’: morphologie, évolution prise par les Anopheles et infectivité des microgamétocytes dePlasmodium yoelii. Ann. Parasit.54 (1979) 145–161.

    Article  CAS  Google Scholar 

  80. Mack, S. R., Samuels, S., and Vanderberg, J. P., Haemolymph ofAnopheles stephensi from uninfected andPlasmodium berghei-infected mosquitoes. 2. Free amino acids. J. Parasit.65 (1979) 130–136.

    Article  PubMed  Google Scholar 

  81. Mack, S. R., Samuels, S., and Vanderberg, J. P., Haemolymph ofAnopheles stephensi from non-infected andPlasmodium berghei-infected mosquitoes. 3. Carbohydrates. J. Parasit.65 (1979) 217–221.

    Article  CAS  PubMed  Google Scholar 

  82. Mack, S. R., and Vanderberg, J. P.,Plasmodium berghei: Energy metabolism of sporozoites. Exp. Parasit.46 (1978) 317–322.

    Article  CAS  PubMed  Google Scholar 

  83. Mack, S. R., Vanderberg, J. P., and Nawrot, R., Column separation ofPlasmodium berghei sporozoites. J. Parasit.64 (1978) 166–168.

    Article  CAS  PubMed  Google Scholar 

  84. Mack, S. R., and Vanderberg, J. P., Haemolymph ofAnopheles stephensi from non-infected andPlasmodium berghei infected mosquitoes. 1. Collection procedure and physical characteristics. J. Parasit.64 (1978) 918–923.

    Article  CAS  PubMed  Google Scholar 

  85. Martin, S. K., Miller, L. H., Nijhout, M. M., and Carter, R.,Plasmodium gallinaceum: Induction of male gametocyte exflagellation by phosphodiesterase inhibitors. Exp. Parasit.44 (1978) 239–242.

    Article  CAS  PubMed  Google Scholar 

  86. Mehlhorn, H., Peters, W., and Haberkorn, A., The formation of kinetes and oocyst inPlasmodium gallinaceum (Haemosporidia) and considerations on phylogenetic relationships between Haemosporidia Piroplasmida and other coccidia. Protistologica15 (1980) 135–154.

    Google Scholar 

  87. Mendis, K. N., and Targett, G. A. T., Immunisation against gametes and asexual erythrocytic stages of a rodent malaria parasite. Nature277 (1979) 389–391.

    Article  CAS  PubMed  Google Scholar 

  88. Meszoely, C. A. M., Erbe, E. F., Steere, R. L., Pacheco, N. D., and Beaudoin, R. L.,Plasmodium berghei: Architectural analysis by freeze-fracturing of the intraoocyst sporozoites pellicular system. Exp. Parasit.53 (1982) 229–241.

    Article  CAS  PubMed  Google Scholar 

  89. Moser, G., Brohn, F. H., Danforth, H. D., and Nussenzweig, R. S., Sporozoites of rodent and simian malaria purified by anion exchange retain their immunogenicity and infectivity. J. Protozool.25 (1978) 119–124.

    Article  CAS  PubMed  Google Scholar 

  90. Nardin, E. H., Gwadz, R. W., and Nussenzweig, R. S. Characterisation of sporozoite surface antigens by indirect fluorescence: Detection of stage- and species-specific antimalarial antibodies. Bull. WHO57 (1979) 211–217.

    PubMed  PubMed Central  Google Scholar 

  91. Nardin, E. H., and Nussenzweig, R. S., Stage-specific antigens on the surface membrane of sporozoites of malaria parasites. Nature274 (1978) 55–57.

    Article  CAS  PubMed  Google Scholar 

  92. Nijhout, M. M.,Plasmodium gallinaceum: exflagellation stimulated by a mosquito factor. Exp. Parasit.48 (1979) 75–80.

    Article  CAS  PubMed  Google Scholar 

  93. Nijhout, M. M., and Carter, R., Gamete development in malaria parasites: Bicarbonate dependent stimulation by p.H. in vitro. Parasitology76 (1978) 39–53.

    Article  CAS  PubMed  Google Scholar 

  94. Nussenzweig, R. S., and Chen, J., The antibody response to sporozoites of simian and human malaria parasites: It's stage and species specificity and strain cross-reactivity. Bull. WHO50 (1974) 293–297.

    CAS  PubMed  PubMed Central  Google Scholar 

  95. Pacheco, N. D., Strome, C. P. A., Mitchell, F., Bawden, M. P., and Beaudoin, R. L., Rapid large scale isolation ofPlasmodium berghei sporozoites from infected mosquitoes. J. Parasit.65 (1979) 414–417.

    Article  CAS  PubMed  Google Scholar 

  96. Peters, W., and Ramkaran, A. E., The influence of p-amino-benzoic acid on the transmission ofPlasmodium yoelii andP. berghei byAnopheles stephensi. Ann. trop. Med. Parasit.74 (1980) 275–282.

    Article  CAS  PubMed  Google Scholar 

  97. Ponnudurai, R., Meuwissen, J. H. E. T., Leeuwenberg, A. D. E., Verhave, J. P., and Lensen, A. H. W., The production of mature gametocytes ofPlasmodium falciparum in continuous cultures of different isolates infective to mosquitoes. Trans R. Soc. trop. Med. Hyg.76 (1982) 242–280.

    Article  CAS  PubMed  Google Scholar 

  98. Porchet, E., and Torpier, G., Etude du germe infectieux deSarcocystis tenella etToxoplasma gondii par la technique du cryodécapage. Z. ParasitKde54 (1977) 101–124.

    Article  CAS  Google Scholar 

  99. Rener, J., Carter, R., Rosenberg, Y., and Miller, L. H., Antigamete monoclonal antibodies synergistically block transmission of malaria by preventing fertilization on the mosquito. Proc. natl. Acad. Sci.77 (1980) 6797–6799.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Rener, J., Graves, P. M., Carter, R., Williams, J. L., and Burkot, T. R., Target antigens of transmission blocking immunity on gametes ofPlasmodium falciparum. J. exp. Med.158 (1983) 976–981.

    Article  CAS  PubMed  Google Scholar 

  101. Roller, N. F., and Desser, S. S., The effect of temperature, age and density of gametocytes and changes in gas composition on exflagellation. Can. J. Zool.51 (1973) 577–587.

    Article  CAS  PubMed  Google Scholar 

  102. Rosales-Ronquillo, M. C., and Silverman, P., In vitro ookinete development of the rodent malaria parasite,Plasmodium berghei. J. Parasit.60 (1974) 819–824.

    Article  CAS  PubMed  Google Scholar 

  103. Rosenberg, R., Koontz, L. C., and Carter, L., Infection ofAedes aegypti with zygotes ofPlasmodium gallinaceum fertilized in vitro. J. Parasit.68 (1982) 653–656.

    Article  CAS  PubMed  Google Scholar 

  104. Russell, D. G., Host cell invasion by Apicomplexa: an expression of the parasite's contractile system? Parasitology87 (1983) 199–209.

    Article  PubMed  Google Scholar 

  105. Russell, D. G., and Burns, R. G., The polar ring of coccidian sporozoites: a unique microtubule-organising centre. J. Cell Sci.65 (1984) 193–207.

    Article  CAS  PubMed  Google Scholar 

  106. Russell, D. G., and Sinden, R. E., The role of the cytoskeleton in the motility of coccidian sporozoites. J. Cell Sci.50 (1981) 345–359.

    Article  CAS  PubMed  Google Scholar 

  107. Rutledge, L. C., Gould, D. J., and Tantichareon, B., Factors affecting the infection of anophelines with human malaria in Thailand. Trans. R. Soc. trop. Med. Hyg.63 (1969) 613–619.

    Article  CAS  PubMed  Google Scholar 

  108. Rutledge, L. C., Ward, R. A., and Hayes, D. E.,Plasmodium cynomolgi: the comparative infectiousness of individual rhesus monkeys. Exp. Parasit.33 (1973) 120–126.

    Article  CAS  PubMed  Google Scholar 

  109. Schiefer, B. A., Ward, R. A., and Eldridge, B. F., Effects of malaria infection on laboratory flight performance ofAnopheles stephensi mosquitoes. Exp. Parasit.41 (1977) 397–404.

    Article  CAS  PubMed  Google Scholar 

  110. Schneider, I., and Vanderberg, J. P., Culture of the invertebrate stages of plasmodia and the culture of mosquito tissues, in: Malaria, vol. 2, pp. 235–270. Ed. J. P. Kreier. Academic Press, New York 1980.

    Google Scholar 

  111. Schrével, J., Asfaux-Foucher, G., and Bafort, J. M., Etude ultrastructurale des mitoses multiples au cours de la sporogonie duPlasmodium b. berghei. J. Ultrastruct. Res.59 (1977) 332–350.

    Article  PubMed  Google Scholar 

  112. Schulman, S., Oppenheim, J. D., and Vanderberg, J. P.,Plasmodium berghei andPlasmodium knowlesi: serum binding to sporozoites. Exp. Parasit.49 (1980) 420–429.

    Article  CAS  PubMed  Google Scholar 

  113. Shute, P. G., The comparative distribution of oocysts of human malaria parasites on the stomach wall ofAnopheles. Trans. R. Soc. trop. Med. Hyg.42 (1948) 324.

    Google Scholar 

  114. Shute, P. G., and Maryon, M., The effect of Pyrimethamine (Daraprim) on the gametocytes and oocysts ofPlasmodium falciparum andPlasmodium vivax. Trans. R. Soc. trop. Med. Hyg.48 (1954) 50–63.

    Article  CAS  PubMed  Google Scholar 

  115. Simm, A., The identification of gameocyte-specific proteins inPlasmodium falciparum. J. Protozool.30 (1983) 42A.

    Google Scholar 

  116. Sinden, R. E., The sporogonic cycle ofPlasmodium yoelii nigeriensis: A scanning electron microscope study. Protistologica11 (1975) 31–39.

    Google Scholar 

  117. Sinden, R. E., Microgametogenesis inPlasmodium yoelii nigeriensis: a scanning electron microscope investigation. Protistologica11 (1975) 263–268.

    Google Scholar 

  118. Sinden, R. E., Cell Biology, in: Rodent Malaria, pp. 88–168. Eds R. Killick-Kendrick and W. Peters. Academic Press, London 1978.

    Google Scholar 

  119. Sinden, R. E., Sexual development of malarial parasites. Adv. Parasit.23 (1983) 154–216.

    Google Scholar 

  120. Sinden, R. E., The cell biology of sexual development in plasmodium. Parasitology86 (1983) 7–28.

    Article  PubMed  Google Scholar 

  121. Sinden, R. E., Canning, E. U., and Spain, B. J., Gametogenesis and fertilization inPlasmodium yoelii nigerensis: a transmission electron microscope study. Proc. R. Soc.193 (1975) 55–76.

    Google Scholar 

  122. Sinden, R. E., and Croll, N. A., Cytology and kinetics of microgametogenesis and fertilization ofPlasmodium yoelii nigeriensis. Parasitology70 (1975) 53–65.

    Article  CAS  PubMed  Google Scholar 

  123. Sinden, R. E., and Garnham, P. C. C., A comparative study of the ultrastructure ofPlasmodium sporozoites within the oocyst and salivary glands with particular reference to the incidence of the micropore. Trans. R. Soc. trop. Med. Hyg.67 (1973) 631–637.

    Article  CAS  PubMed  Google Scholar 

  124. Sinden, R. E., Hartley, R., and King, N., The effect of anti-cytoskeletal agents on microgametogenesis inPlasmodium. Int. J. Parasit. (1985) in press.

  125. Sinden, R. E., and Smalley, M. E., Gametocytes ofPlasmodium falciparum Phagocytosis by leucocytes in vivo and in vitro Trans. R. Soc. trop. Med. Hyg.70 (1976) 344–345.

    Article  CAS  PubMed  Google Scholar 

  126. Sinden, R. E., and Strong, K., An ultrastructural study of the sporogonic development ofPlasmodium falciparum inAnopheles gambiae. Trans. R. Soc. trop. Med. Hyg.72 (1978) 477–491.

    Article  CAS  PubMed  Google Scholar 

  127. Smalley, M. E., and Sinden, R. E.,Plasmodium falciparum gametocytes: their longevity and infectivity. Parasitology74 (1977) 1–8.

    Article  CAS  PubMed  Google Scholar 

  128. Speer, C. A., Rosales-Ronquillo, M. C., and Siverman, P., Scanning electron microscope observations ofPlasmodium berghei ookinetes in primary mosquito cell cultures. J. invert. Path.24 (1974) 179–183.

    Article  CAS  Google Scholar 

  129. Sterling, R. C., Aikawa, M., and Vanderberg, J. P., The passage ofPlasmodium berghei sporozoites through the salivary glands ofAnopheles stephensi: an electron microscope study. J. Parasit.59 (1973) 593–605.

    Article  CAS  PubMed  Google Scholar 

  130. Strome, C. P. A., and Beaudoin, R. L., The surface of the malaria parasite. 1. Scanning electron microscopy of the oocyst. Exp. Parasit.36 (1974) 131–142.

    Article  CAS  PubMed  Google Scholar 

  131. Terzakis, J. A., Uranyl acetate, a strain and a fixative. J. Ultrastruct. Res.22 (1968) 168–184.

    Article  CAS  PubMed  Google Scholar 

  132. Terzakis, J. A., Transformation of thePlasmodium cynomolgi oocyst. J. Protozool.18 (1971) 62–73.

    Article  CAS  PubMed  Google Scholar 

  133. Terzakis, J. A.,Plasmodium gallinaceum: Drug induced ultrastructural changes in the oocysts. Exp. Parasit.30 (1971) 260–266.

    Article  CAS  PubMed  Google Scholar 

  134. Terzakis, J. A., Virus-like particles and sporozoite budding. Proc. helminth. Soc. Wash.39 (1972) 129–137.

    Google Scholar 

  135. Terzakis, J. A., Sprinz, H., and Ward, R. A., Sporoblast and sporozoite formation inPlasmodium gallinaceum infection ofAedes aegypti. Mil. Med.131 (1966) 984–992.

    Article  Google Scholar 

  136. Terzakis, J. A., Sprinz, H., and Ward, R. A., The transformation of thePlasmodium gallinaceum oocyst inAedes aegypti mosquitoes. J. Cell Biol.34 (1967) 311–326.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  137. Terzian, L. A., A method for screening anti-malarial compounds in the mosquito host. Science106 (1947) 449.

    Article  CAS  PubMed  Google Scholar 

  138. Terzian, L. A., The sulphonamides as factors in increasing susceptibility to parasitic invasion. J. infect. Dis.87 (1950) 285–290.

    Article  CAS  PubMed  Google Scholar 

  139. Toyé, P. J., Sinden, R. E., and Canning, E. U., The action of metabolic inhibitors on microgametogenesis inPlasmodium yoelii nigerensis. Z. ParasitKde53 (1977) 133–141.

    Article  Google Scholar 

  140. Turner, D. P., Preliminary observations on, the cell surface ofPlasmodium gallinaceum sporozoites. Trans. Roy. Soc. trop. Med. Hyg.75 (1981) 176–178.

    Article  CAS  PubMed  Google Scholar 

  141. Turner, D. P., Effect of trypsin and neuraminidase on the infectivity ofPlasmodium gallinaceum sporozoites. Ann. trop. Med. Parasit.77 (1983) 119–122.

    Article  CAS  PubMed  Google Scholar 

  142. Turner, D. P., and Gregson, N. A., The cell surface ofPlasmodium gallinaceum sporozoites: microelectrophoretic and lectin binding characteristics. Parasitology84 (1982) 227–238.

    Article  CAS  PubMed  Google Scholar 

  143. Vanderberg, J. P., Studies on the motility ofPlasmodium sporozoites. J. Protozool.21 (1974) 527–537.

    Article  CAS  PubMed  Google Scholar 

  144. Vanderberg, J. P., Development of infectivity by thePlasmodium berghei sporozoite. J. Parasit.61 (1975) 43–50.

    Article  CAS  PubMed  Google Scholar 

  145. Vanderberg, J. P.,Plasmodium berghei: Quantification of sporozoites injected by mosquitoes feeding on a rodent host. Exp. Parasit.42 (1977) 169–181.

    Article  CAS  PubMed  Google Scholar 

  146. Vanderberg, J. P., and Gwadz, R. W., The transmission by mosquitoes of Plasmodia in the laboratory, in: Malaria, vol. 2, pp. 154–234. Ed. J. P. Kreier Academic Press, New York 1980.

    Google Scholar 

  147. Vanderberg, J. R., Nussenzweig, R., and Most, H., Protective immunity produced by the injection of X-irradiated sporozoites ofP. berghei V.In vitro effects of immune serum on sporozoites. Mil. Med.134 suppl. (1969) 1183–1187.

    Article  CAS  PubMed  Google Scholar 

  148. Vanderberg, J. P., Nussenzweig, R. S., Sanabria, Y., Nawrot, R., and Most, H., Stage specificity of antisporozoite antibodies in rodent malaria and its relationship to protective immunity. Proc. helminth Soc. Wash.39 (1972) 514–525.

    Google Scholar 

  149. Vanderberg, J., Rhodin, J., and Yoeli, M., Electron-microscopic and histochemical studies of sporozoite formation inPlasmodium berghei. J. Protozool.14 (1967) 82–103.

    Article  Google Scholar 

  150. Vermeulen, A., unpublished observations.

  151. Vermeulen, A. N., Munster, J. C., van, and Meuwissen, J. H. E. T.,Plasmodium berghei: Immunologically active proteins on the sporozoite surface. Exp. Parasit.53 (1982) 199–208.

    Article  CAS  PubMed  Google Scholar 

  152. Vermeulen, A. N., Ponnudurai, T., Lensen, A. H., Roeffen, W. F. G., and Meuwissen, J. H. E. T., The purification ofPlasmodium falciparum macrogametes and/or zygotes prepared from in vitro cultures. Trans. R. Soc. trop. Med. Hyg.77 (1983) 753–755.

    Article  CAS  PubMed  Google Scholar 

  153. Vermeulen, A. N., Roeffen, W. F. G., Meuwissen, J. H. E. T., and Cochrane, A. H., Molecular weight determination of a malaria sporozoite surface protein purified by immuno-affinity chromatography. Molec. biochem. Parasit. 8 (1984) in press.

  154. Vermeulen, A. N., Roeffen, W. F. G., Munster, J. C. van, and Meuwissen, J. H. E. T., Isolation and characterisation of membrane proteins ofPlasmodium berghei sporozoites. Molec. biochem. Parasit.7 (1983) 197–207.

    Article  CAS  Google Scholar 

  155. Walliker, D., An infection ofPlasmodium berghei derived from sporozoites of a single oocyst. Trans. R. Soc. trop. Med. Hyg.66 (1972) 543.

    CAS  PubMed  Google Scholar 

  156. Walliker, D., The contribution of genetics to the study of Parasitic protozoa. Research Studies Press Limited. Letchworth, Herts. 1983.

    Google Scholar 

  157. Warren, Mc. W., and Collins, W. E., Vector parasite interactions and the epidemiology of malaria, in: Parasitological Topics, p. 266–274. Ed. E. U. Canning. Society of Protozoologists, London 1981.

    Google Scholar 

  158. Weathersby, A. B., The ectopic development of malarial oocysts. Exp. Parasit.3 (1954) 538–543.

    Article  CAS  PubMed  Google Scholar 

  159. Weathersby, A. B., Further studies on the exogenous development of malaria in the haemocoeles of mosquitoes. Exp. Parasit.10 (1960) 211–213.

    Article  CAS  PubMed  Google Scholar 

  160. Weathersby, A. B., Parabiotic twinning of mosquitoes. Mosquito News25 (1965) 44–45.

    Google Scholar 

  161. Weathersby, A. B., The haemocoele as a barrier to parasite infection in insects, in: Invertebrate Immunity, p. 273–288. Eds K. Maramorosch and R. E. Shope. Academic Press, New York 1975.

    Chapter  Google Scholar 

  162. Weiss, M. M., and Vanderberg, J. P., Studies onPlasmodium ookinetes. 1. Isolation and concentration from mosquito midguts. J. Protozool.23 (1976) 547–551.

    Article  CAS  PubMed  Google Scholar 

  163. Weiss, M. M., and Vanderberg, J. P., Studies onPlasmodium ookinetes. 2. In vitro development J. Parasit.63 (1977) 932–934.

    Article  CAS  PubMed  Google Scholar 

  164. Yoeli, M., Movement of the sporozoites ofPlasmodium berghei (Vincke et Lips, 1948). Nature201 (1964) 1344–1345.

    Article  CAS  PubMed  Google Scholar 

  165. Yoeli, M., and Upmanis, R. S.,Plasmodium berghei: ookinete formationin vitro. Exp. Parasit.22 (1968) 122–128.

    Article  CAS  PubMed  Google Scholar 

  166. Yoshida, N., Potocnjak, P., Nussenzweig, V., and Nussenzweig, R. S., Biosynthesis of Pb 44, the protective antigen of sporozoites ofPlasmodium berghei. J. exp. Med.154 (1981) 1225–1236.

    Article  CAS  PubMed  Google Scholar 

  167. Zavala, F., Cochrane, A. H., Nardin, E. H., Nussenzweig, R. S., and Nussenzweig, V., Circumsporozoite proteins of malaria parasites contain a single immunodominant region with two or more identical epitopes. J. exp. Med.157 (1983) 1947–1957.

    Article  CAS  PubMed  Google Scholar 

  168. Zavala, F., Gwadz, R. W., Collins, F. H., Nussenzweig, R. S., and Nussenzweig, V., Monoclonal antibodies to circumsporozoite proteins identify the species of malaria parasite in infected mosquitoes. Nature299 (1982) 737–738.

    Article  CAS  PubMed  Google Scholar 

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Sinden, R.E. The biology ofPlasmodium in the mosquito. Experientia 40, 1330–1343 (1984). https://doi.org/10.1007/BF01951886

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