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A23187 and red cells: Changes in deformability, K+, Mg2+, Ca2+ and ATP

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Summary

A23187 allows red cells to accumulate Ca2+ and become rigid. Excess Mg2+ does not make cells rigid. A23187 also causes K+ efflux, even the absence of added calcium.

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Authors and Affiliations

  1. Departments of Radiation Biology and Biophysics and Department of Medicine, University of Rochester School of Medicine and Dentistry, 260 Crittenden Boulevard, 14642, Rochester, N.Y., USA

    F. H. Kirkpatrick, D. G. Hillman & P. L. La Celle

Authors
  1. F. H. Kirkpatrick
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  2. D. G. Hillman
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  3. P. L. La Celle
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Additional information

This work was supported by USPHS Research grant No. AM16421-04 and is based in part on work performed under contract with the US AEC at the Univ. of Rochester Atomic Energy Project and has been assigned Report No. UR-3490-362.

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Kirkpatrick, F.H., Hillman, D.G. & La Celle, P.L. A23187 and red cells: Changes in deformability, K+, Mg2+, Ca2+ and ATP. Experientia 31, 653–654 (1975). https://doi.org/10.1007/BF01944610

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