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Animal models of breast cancer: Their diversity and role in biomedical research

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Summary

Animal models of breast cancer have been widely used to study various aspects of breast cancer biology, and are remarkably diverse, encompassing chemically and virally induced tumors, human tumor xenografts, and transgenic mouse models. Several novel models have become available during the past few years, including tumors induced by polyomavirus and adenovirus, and a series of human cell line variants. The several following articles describe, in some detail, the characteristics of these models and their relevance to the human disease. Descriptions of each of the major models,e.g., 7,12-dimethylbenz(a)anthracene-induced, MMTV-associated, and human breast cancer cell line xenografts, also are included. The limitations and advantages of several of these models, and some issues relating to the choice of models, are briefly discussed in this overview.

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References

  1. Clarke R, Dickson RB, Lippman ME: Hormonal aspects of breast cancer: growth factors, drugs and stromal interactions. Crit Rev Oncol Hematol 12: 1–23, 1992

    PubMed  Google Scholar 

  2. Clarke R, Lippman ME: Antiestrogen resistance: mechanisms and reversal.In: Teicher BA (ed) Drug Resistance in Oncology. Marcel Dekker, New York, 1992, pp 501–536

    Google Scholar 

  3. Clarke R, Thompson EW, Leonessa F, Lippman J, McGarvey M, Brünner N: Hormone resistance, invasiveness and metastatic potential in human breast cancer. Breast Cancer Res Treat 24:227–239, 1993

    PubMed  Google Scholar 

  4. Russo J, Russo IH: Experimentally induced mammary tumors in rats. Breast Cancer Res Treat 39:7–20, 1996 (this issue)

    PubMed  Google Scholar 

  5. Smith GH: Experimental mammary epithelial morphogenesis in anin vivo model: evidence for distinct cellular progenitors of the ductal and lobular phenotype. Breast Cancer Res Treat 39:21–31, 1996 (this issue)

    PubMed  Google Scholar 

  6. Javier R, Shenk T: Mammary tumors induced by adenovirus type-9: a role for the viral early region 4 gene. Breast Cancer Res Treat 39:57–67, 1996 (this issue)

    PubMed  Google Scholar 

  7. Fluck MM, Haslam SZ: Mammary tumors induced by polyoma virus. Breast Cancer Res Treat 39:45–56, 1996 (this issue)

    PubMed  Google Scholar 

  8. Callahan R: MMTV induced mutations in mouse mammary tumors: their potential relevance to human breast cancer. Breast Cancer Res Treat 39:33–44, 1996 (this issue)

    PubMed  Google Scholar 

  9. Clarke R: Human breast cancer cell line xenografts as models of breast cancer: the immunobiologies of recipient mice and the characteristics of several tumorigenic cell lines. Breast Cancer Res Treat 39:69–86, 1996 (this issue)

    PubMed  Google Scholar 

  10. Brünner N, Spang-Thomsen M, Cullen K: The T61 human breast cancer xenograft: an experimental model of estrogen therapy of breast cancer. Breast Cancer Res Treat 39:87–92, 1996 (this issue)

    PubMed  Google Scholar 

  11. Price JE: Metastasis from human breast cancer cell lines. Breast Cancer Res Treat 39:93–102, 1996 (this issue)

    PubMed  Google Scholar 

  12. Amundadottir LT, Merlino G, Dickson RB: Transgenic mouse models of breast cancer. Breast Cancer Res Treat 39:119–135, 1996 (this issue)

    PubMed  Google Scholar 

  13. Zhang R, Haag JD, Gould MN: Reduction in the frequency of activated ras oncogenes in rat mammary carcinomas with increasing N-methyl-N-nitrosourea doses or increasing prolactin levels. Cancer Res 50:4286–4290, 1990

    PubMed  Google Scholar 

  14. Bos JL:ras oncogenes in human cancer: a review. Cancer Res 49:4682–4689, 1989

    PubMed  Google Scholar 

  15. McLeskey SW, Zhang L, Kharbanda S, Kurebayashi J, Lippman ME, Dickson RB, Kern FG: Fibroblast growth factor overexpressing breast carcinoma cells as models for angiogenesis and metastasis. Breast Cancer Res Treat 39:103–117, 1996 (this issue)

    PubMed  Google Scholar 

  16. Gottardis MM, Jordan VC: Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration. Cancer Res 48:5183–5187, 1988

    PubMed  Google Scholar 

  17. Osborne CK, Coronado EB, Robinson JP: Human breast cancer in athymic nude mice: cytostatic effects of long-term antiestrogen therapy. Eur J Cancer Clin Oncol 23:1189–1196, 1987

    PubMed  Google Scholar 

  18. Belani CP, Pearl P, Whitley NO, Aisner J: Tamoxifen withdrawal response: report of a case. Arch Intern Med 149:449–450, 1989

    PubMed  Google Scholar 

  19. Canney PA, Griffiths T, Latief TN, Priestman TJ: Clinical significance of tamoxifen withdrawal response. Lancet i:36, 1989

    Google Scholar 

  20. Stein W, Hortobagyi GN, Blumenschein GR: Response of metastatic breast cancer to tamoxifen withdrawal: report of a case. J Surg Oncol 22:45–46, 1983

    PubMed  Google Scholar 

  21. Gottardis MM, Wagner RJ, Borden EC, Jordan CV: Differential ability of antiestrogens to stimulate breast cancer cell (MCF-7) growth in vivo and in vitro. Cancer Res 49:4765–4769, 1989

    PubMed  Google Scholar 

  22. Screpanti I, Santoni A, Gulino A, Herberman RB, Frati L: Estrogen and antiestrogen modulation of mouse natural killer activity and large granular lymphocytes. Cell Immunol 106:191–202, 1987

    PubMed  Google Scholar 

  23. Seaman WE, Blackman MA, Gindhart TD, Roubinian JR, Loeb JM, Talal N: β-estradiol reduces natural killer cells in mice. J Immunol 121:2193–2198, 1978

    PubMed  Google Scholar 

  24. Hanna N, Schneider M: Enhancement of tumor metastases and suppression of natural killer cell activity by β-estradiol treatment. J Immunol 130: 974–980, 1983

    PubMed  Google Scholar 

  25. Seaman WE, Talal N: The effect of 17β-estradiol on natural killing in the mouse.In: Herberman RB (ed) Natural Cell-Mediated Immunity against Tumors. Academic Press, New York, 1980, pp 765–777

    Google Scholar 

  26. Berry J, Green BJ, Matheson DS: Modulation of natural killer cell activity in stage I postmenopausal breast cancer patients on low-dose aminogluthemide. Cancer Immunol Immunother 24:72–75, 1987

    PubMed  Google Scholar 

  27. Bae S-N, Arand G, Azzam H, Pavasant P, Torri J, Frandsen TL, Thompson EW: Molecular and cellular analysis of basement membrane invasion by human breast cancer cells in Matrigel-based in vitro assays. Breast Cancer Res Treat 24:241–255, 1993

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Vincent T. Lombardi Cancer Center and Department of Physiology & Biophysics, W405A The Research Building, Georgetown University Medical School, 3970 Reservoir Road NW, 20007, Washington DC, USA

    Robert Clarke

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Clarke, R. Animal models of breast cancer: Their diversity and role in biomedical research. Breast Cancer Res Tr 39, 1–6 (1996). https://doi.org/10.1007/BF01806073

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