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Optimal characteristics of agents to treat uncomplicated urinary tract infections

Optimale Eigenschaften antimikrobieller Substanzen für die Behandlung unkomplizierter Harnwegsinfektionen

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Summary

The optimal characteristics of agents to treat uncomplicated urinary tract infection must include activity against the major pathogens involved in these infections as well as a low potential for development of bacterial resistance. High urinary levels should be present for an adequate period to eliminate the organisms. Side effects should be minimal with minimal effect on the bacterial flora of the community. Treatment programs of single-dose, three days, or five days can be developed depending upon the agent.

Zusammenfassung

Optimale Substanzen für die Behandlung unkomplizierter Harnwegsinfektionen sollten wirksam gegen die wichtigsten Erreger sein und ein geringes Potential zur Resistenzentwicklung von Bakterien aufweisen. Für die Elimination der Erreger sind hohe Urinspiegel für einen adäquaten Zeitraum erforderlich. Die Nebenwirkungen sollten möglichst gering sein, und die Therapie sollte auf die bakterielle Flora der Allgemeinbevölkerung möglichst wenig Einfluß haben. Abhängig von der Substanz können Therapieregime für eine Einmaldosis-Behandlung, drei- oder fünf-Tagestherapien entwickelt werden.

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  1. College of Physicians and Surgeons, Columbia University, 630 West 168 Street, 10032, New York, NY, USA

    H. C. Neu M. D. (F.A.C.P.)

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Neu, H.C. Optimal characteristics of agents to treat uncomplicated urinary tract infections. Infection 20 (Suppl 4), S266–S271 (1992). https://doi.org/10.1007/BF01710012

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