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A study of inhalation of pentachlorophenol by rats IV. Distribution and excretion of inhaled pentachloropenol

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Summary

It appears that in the rat repeated respiratory exposures to PCP do not result in an increase in the body burden of this compound as would be suspected from the 24 hour half-life determined from a single inhalation exposure. These results suggest some mechanism induced by prior exposure to PCP that increases the ability of the animals to remove this compound from its body. Increased excretion may be a factor in this activity, however, it cannot account for the total effect. Storage appears unlikely, since the elimination rate and time period remain unchanged after five doses as compared to after one. Increased metabolism may be the explanation, although this mechanism can only be inferred from these data. Quantitative metabolic results will be necessary to support this hypothesis.

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Authors and Affiliations

  1. Department of Pharmacology, University of Hawaii, 3675 Kilauea Avenue, 96816, Honolulu, Hawaii

    Heinz J. Hoben, Stephanie A. Ching & Louis J. Casarett

Authors
  1. Heinz J. Hoben
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  2. Stephanie A. Ching
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  3. Louis J. Casarett
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Additional information

deceased

Not more than 12 animals could be exposed simultaneously since the exposure chamber has only 12 exposure sites.

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Hoben, H.J., Ching, S.A. & Casarett, L.J. A study of inhalation of pentachlorophenol by rats IV. Distribution and excretion of inhaled pentachloropenol. Bull. Environ. Contam. Toxicol. 15, 466–474 (1976). https://doi.org/10.1007/BF01685074

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  • DOI: https://doi.org/10.1007/BF01685074

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