Abstract
Using data on 4726 cases of uveal melanoma collected by the Registry, of Ophthalmic Pathology at the Armed Forces Institute of Pathology, my co-workers and I have been studying the biology of haematogenous metastasis. We have developed methods for evaluating separately the relationships between prognostic factors and cure-rate and median survival time for uncured patients. We have discovered that size of the tumour and size of the largest nucleoli in the cells of the uveal melanomas related equally to cure-rate and median survival time. The presence of Callender's epitheloid-type cells in the tumour and increased patient age had little effect on cure-rate but dramatically reduced the median survival time.
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References
Boag JW (1949) Maximum likelihood estimates of the proportion of patients cured by cancer therapy. J R Stat Soc [B] 11:15–44
Callender GR (1931) Malignant melanocytic tumors of the eye: a study of histologic types in 111 cases. Trans Am Acad Opthalmol Otolaryngol 36:131–142
Cox DR (1972) Regression models and life-tables. J R Stat Soc 135:185–206
Cutler SJ, Axtell LM (1969) Adjustments of long-term survival rates for deaths due to intercurrent disease. J Chron Dis 22:485–491
Cruz PO de la Jr, Specht CS and McLean IW (1990) Lymphocytic infiltration in uveal malignant melanoma. Cancer 65:112–115
Elandt-Johnson RC, Johnson NL (1980) Survival models and data analysis. Wiley, New York, pp 269–341
Fidler IJ (1990) Critical factors in the biology of Human cancer metastasis: 28th G.H.A. Clowes Memorial Award Lecture. Cancer Res 50:6130–6138
Gamel JW, McLean IW, Greenberg RA, Zimmerman LE, Lichtenstein SJ (1982) Computerized histologic assessment of malignant potential: a method for determining the prognosis of uveal melanomas. Hum Pathol 13:893–897
Gamel JW, McLean IW and Rosenberg SH (1990) Proportion cured and mean log survival time as functions of tumor size. Stat Med 9:999–1006
Gamel JW, McLean IW, McCurdy JB (1993) Biological distinctions between Cure and time to death in 2892 patients with intraocular melanoma. Cancer 71:2299–2305
Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22:719–748
McCurdy J, Gamel J, McLean I (1991) A simple, efficient, and reproducible method for estimating the malignant potential of uveal melanoma from routine H & E slides. Pathol Res Pract 187:1025–1027
Mould RF, Boag JW (1975) A test of several parametric statistical models for estimating success rate in the treatment of carcinoma of cervix uteri. Br J Cancer 32:529–550
Mould RF, Hearnden T, Palmer M, White GC (1976) Distribution of survival times of 12000 head and neck cancer patients who died with their disease. Br J Cancer 34:180–190
Quax PH, van Muijen GNP, Weening-Verhoeff EJD, Lund LR, Dano K, Ruiter DJ, Verheijen JH (1991) Metastatic behavior of human melanoma cell lines in nude mice correlates with urokinase-type plasminogen activator, its type 1 inhibitor, and urokinase mediated matrix degradation. J Cell Biol 115:191–199
Rutqvist LE, Wallgren A, Nilsson B (1984) Is breast carcinoma a curable disease? Cancer 53:1793–1800
Wilder HC, Callender GR (1939) Malignant melanoma of the choroid. Further studies on prognosis by histologic type and fiber content. Am J Ophthalmol 22:851–855
Wilder HC, Paul EV (1951) Malignant melanoma of the choroid and ciliary body: a study of 2535 cases. Milit Surg 109:370–378
Zimmerman LE, McLean IW (1980) The natural course of untreated uveal melanomas. Doc Ophthalmol 50:75–82
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McLean, I.W. The biology of haematogenous metastasis in human meal malignant melanoma. Vichows Archiv A Pathol Anat 422, 433–437 (1993). https://doi.org/10.1007/BF01606450
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DOI: https://doi.org/10.1007/BF01606450