Summary
Monkey interferon (MKIF) produced in monkey BSC-1 cells infected with Newcastle disease virus showed antiviral activity on human foreskin fibroblasts and RD114 cells—a human line transformed by feline sarcoma virus. The titer of the monkey interferon in human cells was 10–30 fold greater than that found in several normal monkey (BSC-1, CV-1) or SV40 transformed (C2, C6, T-22) monkey cell lines tested. Ten to fifteen-fold purification of MKIF without loss of activity could be achieved by chromatography on Phenyl-Sepharose CL-4B. Antiviral activity of MKIF was fully resistant to treatment with 1 per cent sodium dodecyl sulfate (SDS).
References
Anfinsen, C. B., Bose, S., Corley, L., Gurari-Rotman, D.: Partial Purification of Human Interferon by Affinity Chromatography. Proc. Natl. Acad. Sci. U.S.A.71, 3139–3142 (1974).
Armstrong, J. A.: Semi-micro Dye-binding Assay for Rabbit Interferon. Applied Microbiol.21, 723–725 (1971).
Bucknall, R. A.: Species Specificity of Interferons: A Misnomer? Nature216, 1022–1023 (1967).
Desmyter, J., Melnick, J. L., Rawls, W. E.: Defectiveness of Interferon Production and of Rubella Virus Interferences in a line of African green Monkey Kidney Cells (Vero). J. Virol.2, 955–961 (1968).
Havell, E. A., Yip, Y. K., Vilček, J.: Correlation of Physicohemical and Antigenic Properties of Human Leukocyte Interferon Subspecies. Arch. Virol.55, 121–129 (1977).
Jankowski, W. J., Davey, M. W., O'Malley, J. A., Sulkowski, E., Carter, W. A.: Molecular Structure of Human Fibroblast and Leukocyte Interferons: Probe by Lectin and Hydrophobic Chromatography. J. Virol.16, 1124–1130 (1975).
Jones, B. R., Galbraith, J. E. K., Al-Hussaini, M. K.: Vaccinial Keratitis Treated with Interferon. Lancet1, 875–879 (1962).
Lin, L. S., Wiranowska-Stewart, M., Chudzio, T., Stewart II, W. E.: Characterization of the Heterogeneous Molecules of Human Interferons: Differences in the Cross-Species Antiviral Activities of Various Molecular Populations in human Leukocyte Interferons. J. gen. Virol.39, 125–130 (1978).
Mogensen, K. E., Cantell, K.: Human Leukocyte Interferon: a Role for Disulphide Bonds. J. gen. Virol.22, 95–103 (1974).
Oxman, M. N., Levin, M. J., Lewis, A. M., Jr.: Control of Simian Virus 40 Gene Expression in Adenovirus-Simian Virus 40 Hybrid Viruses. Synthesis of Hybrid Adeno-virus 2-Simian Virus 40 RNA Molecules in Cells infected with a nondefective Adenovirus 2-Simian Virus 40 Hybrid Virus. J. Virol.13, 322–330 (1974).
Pollikoff, R., Donikian, M. A., Padron, A., Lin, O. C.: Tissue Specificity of Interferon Prepared in Various Tissue Cultures. Proc. Soc. exp. Biol. Med.110, 232–234 (1962).
Salzberg, S., Heller, A., Aboud, M., Gurari-Rotman, D., Revel, M.: Antiviral Effect of Human Interferon on Human Cells Releasing Oncornaviruses. Virology (in press).
Samuel, C. E., Farris, D. A.: Mechanism of Interferon Action. Species Specificity of Interferon and of the Interferon-Mediated Inhibitor of Translation from Mouse, Monkey and Human Cells. Virology77, 556–565 (1977).
Stewart II, W. E., de Clercq, E., de Somer, P.: Stabilization of Interferon by Defensive Reversible Denaturation. Nature249, 460–461 (1974).
Stewart II, W. E., Desmyter, J.: Molecular Heterogeneity of Human Leukocyte Interferon: Two Populations Differing in Molecular Weights, Requirements for Renaturation and Cross-Species Antiviral Activity. Virology67, 68–77 (1975).
Sutton, R. N. P., Tyrell, D. A. J.: Some Observations on Interferon Prepared in Tissue Cultures. Brit. J. exp. Pathol.42, 99 (1961).
Vilček, J., Havell, E. A.: Stabilization of Interferon Messenger RNA Activity by Treatment of Cells with Metabolic Inhibitors and Lowering of the Incubation Temperature. Proc. Nat. Acad. Sci. U.S.A.70, 3909–3913 (1973).
Yakobson, E., Revel, M., Winocour, E.: Inhibition of Simian Virus 40 Replication by Interferon Treatment Late in the Lytic Cycle. Virology80, 225–228 (1977).
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Yakobson, E., Revel, M. & Gurari-Rotman, D. Monkey interferon: Activity on human cells and chromatographic properties. Archives of Virology 59, 251–255 (1979). https://doi.org/10.1007/BF01317420
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DOI: https://doi.org/10.1007/BF01317420