Summary
Recombinant vaccinia virus expressing the middle hepatitis B virus surface antigen was incapable of inducing marked antibody response against the S and pre-S2 antigenic specifities in mice. However, mice immunized with this virus produced antibodies to both these antigens after the following administration of subtreshold doses of plasmatic hepatitis B surface antigen.
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Hamšíková, E., Závadová, H., Kutinová, L. et al. Priming effect of recombinant vaccinia virus coding for the middle hepatitis B surface antigen. Archives of Virology 113, 283–289 (1990). https://doi.org/10.1007/BF01316681
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DOI: https://doi.org/10.1007/BF01316681