Summary
We have established a method for detecting virus receptors in the tissue sections and have been able to clarify the distribution of cellular receptors for Sendai virus in various mouse organs, including trachea, esophagus, large intestine and cerebrum.
The virus receptors were detected in ciliated cells of the trachea, as to be expected for a pneumotropic virus. The lamina propria and connective tissue of the mouse esophagus and large intestine, immediately under the epithelium, contained an abundance at virus receptors, but very few were detected in the epithelium of these organs. In mouse cerebrum, the cells lining the ventricles had a large number of virus receptors.
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Appell, L. H., Kovatch, R. M., Reddecliff, J. M., Gerone, P. J.: Pathogenesis of Sendai virus infection in mice. Am. J. Vet. Res.32, 1835–1841 (1971).
Harter, D. H., Choppin, P. W.: Adsorption of attenuated and neurovirulent poliovirus strains to central nervous system of primates. J. Immunol.95, 730–736 (1965).
Haywood, A. M.: Characteristics of Sendai virus receptors in a model membrane. J. Mol. Biol.83, 427–436 (1974).
Holland, J. J., McLaren, L. C.: The mammalian cell-virus relationship. II. Adsorption, reception, and eclipse of poliovirus by HeLa cells. J. Exp. Med.109, 487–504 (1959).
Holmgren, J., Sennerholm, L., Elwing, H., Fredman, P., Strannergrad, O.: Sendai virus receptor: Proposed recognition structure based on binding to plasticadsorbed gangliosides. Proc. Natl. Acad. Sci. U.S.A.77, 1947–1950 (1980).
Ito, Y., Kimura, Y., Nagata, I., Kunii, A.: Effects of l-glutamine deprivation on growth of HVJ (Sendai virus) in BHK cells. J. Virol.13, 557–566 (1974).
Ito, Y., Yamamoto, F., Takano, M., Maeno, K., Shimokata, K., Iinuma, M., Hara, K., Iijima, S.: Comparative studies on the distribution mode of orthomyxo-virus and paramyxo-virus receptor possessing cells in mice and birds. Med. Microbiol. Immunol.171, 59–68 (1982).
Kida, H., Yanagawa, R., Matsuoka, Y.: Duck influenza lacking evidence of disease signs and immune response. Infect. Immun.30, 547–553 (1980).
Kunin, C. M.: Virus-tissue union and the pathogenesis of enterovirus infections. J. Immunol.88, 556–569 (1962).
McLaren, L. C., Holland, J. J., Syverton, J. T.: The mammalian cell-virus relationship. I. Attachment of poliovirus to cultivated cells of primate and non-primate origin. J. Exp. Med.109, 475–485 (1959).
Mims, C. A., Murphy, F. A.: Parainfluenza virus Sendai infection in macrophages, ependyma, choroid plexus, vascular endothelium and respiratory tract of mice. Am. J. Pathol.70, 315–328 (1973).
Robinson, T. W. E., Cureton, R. J. R., Heath, R. B.: The pathogenesis of Sendai virus infection in the mouse lung. J. Med. Microbiol.1, 89–95 (1968).
Shimokata, K., Nishiyama, Y., Ito, Y., Kimura, Y., Nagata, I., Iida, M., Sobue, I.: Pathogenesis of Sendai virus infection in the central nervous system of mice. Infect. Immun.13, 1497–1502 (1976).
Van Nunen, M. C. J., Van der Veen, J.: Experimental infection with Sendai virus in mice. Arch. ges. Virusforsch.22, 388–397 (1976).
Webster, R. G., Yakhno, N., Hinshaw, V. S., Bean, W. J., Murti, K. G.: Intestine influenza: Replication and characterization of influenza viruses in ducks. Virology84, 268–278 (1978).
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Ito, Y., Yamamoto, F., Takano, M. et al. Detection of cellular receptors for Sendai virus in mouse tissue sections. Archives of Virology 75, 103–113 (1983). https://doi.org/10.1007/BF01314130
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DOI: https://doi.org/10.1007/BF01314130