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Usefulness of different myocardial sampling zones for the postmortem diagnosis of myocardial infarction

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Summary

The diagnosis of myocardial infarction requires the use of a group of tests that are very efficient, quick and inexpensive. Another important consideration is the choice of myocardial sampling zones, especially in cases of differential diagnosis between a cardiac injury secondary to a trauma or violent asphyxia and others, secondary to myocardial infarction. The aim of this work was to choose, through discriminant analysis, the most useful zones of cardiac tissue for the quantification of free fatty acids and free carnitine and for the performance of the K/Na quotient, as biochemical parameters for the postmortem diagnosis of myocardial infarction. According to the discriminant analysis performed, seven zones of cardiac tissue are necessary to achieve a differential diagnosis among “myocardial infarction,” “other natural deaths,” and “violent deaths” with a 71.9% efficacy. Greater diagnostic efficacy was found (78.1%) for differentiating between “natural deaths” and “violent deaths.”

Zusammenfassung

Für die postmortale Herzinfarkt-Diagnose braucht man heutzutage eine einfache und billige, aber aussagekräftige Gruppe von Labortests. Das erste wichtige Problem ist die Auswahl von geeigneten Herzgebieten für die biochemischen Analysen, vor allem wenn eine Differentialdiagnose zwischen Trauma, Erstickung oder Herzinfarkt vorgenommen werden muß. In dieser Arbeit haben wir die geeigneten Herzgebiete für eine postmortale Herzinfarkt-Diagnose mit verschiedenen Tests (Quotient K/Na, freie Fettsäuren und freies Karnitin) untersucht.

Bei Anwendung der Diskriminanzanalyse sind acht verschiedene Herzgebiete erforderlich, um für die Differentialdiagnose zwischen „Herzinfarkt-Tod“, „gewaltsamen Tod“ und „natürlichen Tod“ mit 71.9% Genauigkeit machen zu können.

Eine sehr hohe diagnostische Sicherheit (78.1) haben die Verf. für die Differentialdiagnose zwischen „natürlichem Tod“ und „gewaltsamen Tod“ gefunden.

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Lachica, E., Luna, A. & Villanueva, E. Usefulness of different myocardial sampling zones for the postmortem diagnosis of myocardial infarction. Z Rechtsmed 103, 111–119 (1989). https://doi.org/10.1007/BF01258914

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