Abstract
Glycosomes are intracellular, microbody-like organelles found in all members of the protist order Kinetoplastida examined. Nine enzymes involved in glucose and glycerol metabolism are associated with these organelles. These enzymes are involved in pathways which, in other organisms, are usually located in the cytosol. This paper reviews our current knowledge about the glycosome and its constituent enzymes, with special reference to the organelle ofTrypanosoma brucei.
Similar content being viewed by others
References
Alexander, K., and Parsons, M. (1991).Mol. Biochem. Parasitol. 46 1–10.
Allert, S., Ernest, I., Poliszczak, A., Opperdoes, F. R., and Michels, P. A. M. (1991).Eur. J. Biochem. 200 19–27.
Blattner, J., Swinkels, B. W., Dörsam, H., Prospero, T., Subramani, S., and Clayton, C. (1992).J. Cell Biol. 119 1129–1136.
Borst, P. (1988).Biochim. Biophys. Acta 1008 1–13.
Bowman, I. B. R., and Flynn, I. W. (1976). InBiology of the Kinetoplastida (Lumsden, W. H. R., and Evans, D. A., eds.), Academic Press, New York, pp. 435–476.
Callens, M., Kuntz, D. A., and Opperdoes, F. R. (1991).Mol. Biochem. Parasitol. 47 19–30.
Cavalier-Smith, T. (1987).Nature 326 332–333.
Clayton, C. (1985).EMBO J. 4 2997–3003.
Clayton, C. (1987).J. Cell Biol. 105 2649–2653.
Clayton, C. (1988).Mol. Biochem. Parasitol. 28 43–46.
Cronin, C. N., and Tipton, K. F. (1985).Biochem. J. 227 113–124.
Cronin, C. N., and Tipton, K. F. (1987).Biochem. J. 247 41–46.
Fung, K., and Clayton, C. (1991).Mol. Biochem. Parasitol. 45 261–264.
Hammond, D. J., Gutteridge, W. E., and Opperdoes, F. R. (1981).FEBS Lett. 128 27–29.
Hammond, D. J., Aman, R. A., and Wang, C. C. (1985).J. Biol. Chem. 260 15646–15654.
Hannaert, V., Blaauw, M., Kohl, L., Allert, S., Opperdoes, F. R., and Michels, P. A. M. (1992).Mol. Biochem. Parasitol. 55 115–126.
Hart, D. T., and Opperdoes, F. R. (1984).Mol. Biochem. Parasitol. 13 159–172.
Hart, D. T., Misset, O., Edwards, S. W., and Opperdoes, F. R. (1984).Mol. Biochem. Parasitol. 12 25–35.
Hart, D. T., Baudhuin, P., Opperdoes, F. R., and de Duve, C. (1987).EMBO J. 6 1403–1411.
Kendall, G., Wilderspin, A. W. F., Ashall, F., Miles, M. A., and Kelly, J. M. (1990).EMBO J. 9 2751–2758.
Kohl, L., Callens, M., Wierenga, R. K., Opperdoes, F. R., and Michels, P. A. M. (1994).Eur. J. Biochem. in press.
Lambeir, A.-M., Opperdoes, F. R., and Wierenga, R. K. (1987).Eur. J. Biochem. 168 69–74.
Lambeir, A.-M., Loiseau, A. M., Kuntz, D. A., Vellieux, F. M., Michels, P. A. M., and Opperdoes, F. R. (1991).Eur. J. Biochem. 198 429–435.
Marchand, M., Poliszczak, A., Gibson, W. C., Wierenga, R. K., Opperdoes, F. R., and Michels, P. A. M. (1988).Mol. Biochem. Parasitol. 29 65–76.
Marchand, M., Kooystra, U., Wierenga, R. K., Lambeir, A.-M., Van Beeumen, J., Opperdoes, F. R., and Michels, P. A. M. (1989).Eur. J. Biochem. 184 455–464.
Michels, P. A. M., and Hannaert, V. (1994).J. Bioenerg. Biomembr. 26 213–219.
Michels, P. A. M., Poliszczak, A., Osinga, K. A., Misset, O., Van Beeumen, J., Wierenga, R. K., Borst, P., and Opperdoes, F. R. (1986).EMBO J. 5 1049–1056.
Michels, P. A. M., Marchand, M., Kohl, L., Aleert, S., Wierenga, R. K., and Opperdoes, F. R. (1991).Eur. J. Biochem. 198 421–428.
Misset, O., and Opperdoes, F. R. (1984).Eur. J. Biochem. 144 475–483.
Misset, O., and Opperdoes, F. R. (1987).Eur. J. Biochem. 162 493–500.
Misset, O., Bos, O. J. M., and Opperdoes, F. R. (1986).Eur. J. Biochem. 157 441–453.
Misset, O., Van Beeumen, J., Lambeir, A.-M., Van der Meer, R., and Opperdoes, F. R. (1987).Eur. J. Biochem. 162 501–507.
Mottram, J. C., and Coombs, G. H. (1985).Exp. Parasitol. 59 265–274.
Opperdoes, F. R. (1981). Quoted inParasitology, 80 (Klein, R. A., and Miller, P. G. G., eds.), Cambridge University Press, Cambridge, UK, pp. 1–30.
Opperdoes, F. R. (1984).FEBS Lett. 169 35–39.
Opperdoes, F. R. (1987).Annu. Rev. Microbiol. 41 127–151.
Opperdoes, F. R. (1988).Trends Biochem. Sci. 13 255–260.
Opperdoes, F. R., and Borst, P. (1977).FEBS Lett. 80 360–364.
Opperdoes, F. R., and Cottem, D. (1982).FEBS Lett. 143 60–64.
Opperdoes, F. R., Markos, A., and Steiger, R. F. (1981).Mol. Biochem. Parasitol. 4 291–309.
Opperdoes, F. R., Baudhuin, P., Coppens, I., De Roe, C., Edwards, S. W., Weijers, P., and Misset, O. (1984).J. Cell Biol. 98 1178–1184.
Opperdoes, F. R., Nohynkova, E., Van Schaftingen, E., Lambeir, A.-M., Veenhuis, M., and Van Roy, J. (1988).Mol. Biochem. Parastiol. 30 155–164.
Osinga, K. A., Swinkels, B. W., Gibson, W. C., Borst, P., Veeneman, G. H., Van Boom, J. H., Michels, P. A. M., and Opperdoes, F. R. (1985).EMBO J. 4 3811–3817.
Sanchez-Moreno, M., Lasztity, D., Coppens, I., and Opperdoes, F. R. (1992).Mol. Biochem. Parasitol. 54 185–200.
Sommer, J. M., Cheng, Q.-L., Keller, G. A., and Wang, C. C. (1992).Mol. Biol. Cell 3 749–759.
Swinkels, B. W., Gibson, W. C., Osinga, K. A., Kramer, R., Veeneman, G. H., Van Boom, J. H., and Borst, P. (1986).EMBO J. 5 1291–1298.
Swinkels, B. W., Evers, R., and Borst, P. (1988).EMBO J. 7 1159–1165.
Swinkels, B. W., Gould, S. J., Bodnar, A. G., Rachubinski, R. A., and Subramani, S. (1991).EMBO J. 10 3255–3262.
Swinkels, B. W., Loiseau, A., Opperdoes, F. R., and Borst, P. (1992).Mol. Biochem. Parasitol. 50 69–78.
Taylor, M. B., Berghausen, H., Heyworth, P., Messenger, N., Rees, L. J., and Gutteridge, W. E. (1979).J. Biochem. 11 117–120.
Tetley, L., and Coombs, G. H. (1983).Parasitology 87 xxxvi.
Vellieux, F. M. D., Hajdu, J., Verlinde, C. L. M. J., Groendijk, H., Read, R. J., Greenhough, T. J., Campbell, J. W., Kalk, K. H., Littlechild, J. A., Watson, H. C., and Hol, W. G. J. (1993).Proc. Natl. Acad. Sci. USA 90 2355–2359.
Visser, N., and Opperdoes, F. R. (1980).Eur. J. Biochem. 103 623–632.
Visser, N., Opperdoes, F. R., and Borst, P. (1981).Eur. J. Biochem. 118 521–526.
Wierenga, R. K., Swinkels, B. W., Michels, P. A. M., Osinga, K., Misset, O., Van Beeumen, J., Gibson, W. C., Postma, J. P. M., Borst, P., Opperdoes, F. R., and Hol, W. G. J. (1987).EMBO J. 6 215–221.
Wierenga, R. K., Nobel, M. E. M., Vriend, G., Nauche, S., and Hol, W. G. J. (1991).J. Mol. Biol. 220 995–1015.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hannaert, V., Michels, P.A.M. Structure, function, and biogenesis of glycosomes in Kinetoplastida. J Bioenerg Biomembr 26, 205–212 (1994). https://doi.org/10.1007/BF00763069
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00763069