Abstract
Rats were trained to escape electric shock by running into one arm of a T-maze on 10-trial daily sessions with pentobarbital (10mg/kg), and to the opposite arm of the maze on other sessions with saline, the drug and saline sessions being alternated. This drug-learning dissociation or state-dependent learning was achieved by rats with medial septal lesions, abolishing hippocampal theta activity, as efficiently as rats with cortical lesions and intact rats. The suggested relationship between drug-learning dissociation and the suppression of hippocampal theta waves, produced by the drug, was not evidenced.
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Irisawa, N., Iwahara, S. & Fukuda, S. Abolition of the hippocampal theta activity and drug-learning dissociation. Psychopharmacology 47, 203–204 (1976). https://doi.org/10.1007/BF00735823
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DOI: https://doi.org/10.1007/BF00735823