Abstract
The teratogenic potential of inhaled dichlorvos vapour for rabbits and rats was investigated on the offspring of primiparous female Dutch rabbits weighing 2 to 3 kg and primiparous female Carworth E strain rats weighing 200 to 300 g. The animals were exposed throughout pregnancy at concentrations of 0.25, 1.25 and 6.25 μg dichlorvos per litre of air. In an additional experiment pregnant rabbits were exposed to concentrations of 2 and 4 μg dichlorvos per litre of air. The results gave no indication that dichlorvos vapour is teratogenic in rabbits or rats even at exposure concentrations resulting in maternal deaths in rabbits, and causing depression of plasma, erythrocyte and brain cholinesterase activities in pregnant animals of both species.
Zusammenfassung
An Kaninchen und Ratten wurde die teratogene Wirkung von inhaliertem Dichlorvos untersucht. Im Versuch waren primipare Kaninchenweibchen der Rasse “Dutch” mit einem Anfangsgewicht von 2 bis 3 kg und primipare Rattenweibchen vom Stamm “Carworth Farm E“ mit einem Anfangsgewicht von 200 bis 300 g. Die Tiere wurden während der gesamten Trächtigkeit folgenden Konzentrationen in der Atemluft ausgesetzt: 0,25, 1,25 und 6,25 μg Dichlorvos pro Liter Luft. Ein zusätzliches Experiment am Kaninchen wurde mit 2 und 4 μg Dichlorvos pro Liter Luft durchgeführt. Die Behandlung wirkte weder beim Kaninchen noch bei der Ratte teratogen. Selbst Konzentrationen, die für die Kaninchen tödlich waren, und die eine deutliche Cholinesterasehemmung in Plasma, Erythrocyten und Gehirn der Ratten und Kaninchen hervorriefen, wurden ohne Schädigung für die Feten vertragen.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Blair, D., Rees, H. J.: The generation and administration of atmospheres containing diohlorvos for inhalation studies (In preparation).
Collins, J. A., Schooley, M. A., Singh, V. K.: The effect of the dietary dichlorvos on swine reproduction and viability of their offspring. Abstracts of the Tenth Annual Meeting of the Society of Toxicology. Toxicol. appl. Pharmacol.19, Abstract No. 41,19, (2) (1971).
Dawson, A. B.: A note on the staining of the skeleton of cleared specimens. Stain Technol.1, 123 (1926).
Delahunt, C. S.: Detection of teratogenic actions. In: Methods in toxicology. (Paget, G. E., Ed.). Oxford and Edinburgh: Blackwell: 1970
Elgar, K. E., Steer, B. D.: Dichlorvos concentrations in the air of houses arising from the use of Vapona strips. Pesticide Sci. (In press).
Hutson, D. H., Hoadley, E. C., Pickering, B. A.: The metabolic fate of [14-C] Diehlorvos in the rat after oral and inhalation exposure. Xenobiotica. (In press).
Kimbrough, E. D., Gaines, R. B.: Effect of organic phosphorus compounds and alkylating agents on the rat foetus. Arch. environm. Hlth16, 805–808 (1968).
Pickering, C. E., Pickering, R. G.: Methods for the estimation of acetylcholine activity in the plasma and brain of laboratory animals given carbamates or organophosphorus compounds. Arch. Toxikol.27, 293–310 (1971).
Pickering, C. E., Pickering, R. G.: Methods for the estimation of acetyl cholinesterase in the erythrocytes of laboratory animals. (In preparation).
Robson, J. M.: Testing drugs for teratogenicity and their effects on fertility. Brit. med. Bull.26, 212–216 (1970).
Tenny, S. M.: In: Dukes physiology of domestic animals, 8th Ed. (Swenson, M. J., Ed.). Ithaca and London: Cornell University Press 1970.
Upshall, D. G., Roger, J. C., Casida, J. E.: Biochemical studies on the teratogenic action of Bidrin and other neuroactive agents in developing hens eggs. Biochem. Pharmacol.17, 1529–1542 (1968).
Vogin, E. E., Carson, S., Slomka, M. B.: Teratology studies with dichlorvos in rabbits. Abstracts of the Tenth Annual Meeting of the Society of Toxicology. Toxicol. appl. Pharmacol. Abstract No. 42,19 (2) (1971).
Wilson, J. G.: Embryological considerations in teratology. Teratology, principles and techniques. Chicago: Univ. of Chic. Press 1965.
Witherup, S., Jolley, W. J., Stemmer, K., Pfitzer, E. A.: Chronic toxicity studies with 2,2-dichlorovinyl dimethyl phosphate (DDVP) in dogs and rats including observations on rat reproduction. Abstracts of the Tenth Annual Meeting of the Society of Toxicology. Toxicol. appl. Pharmacol. Abstract No. 40,19, (2) (1971).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Thorpe, E., Wilson, A.B., Dix, K.M. et al. Teratological studies with dichlorvos vapour in rabbits and rats. Arch. Toxikol. 30, 29–38 (1972). https://doi.org/10.1007/BF00605271
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00605271