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X linkage of phosphoglycerate kinase in the mouse

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Abstract

The levels of phosphoglycerate kinase (PGK), glucose 6-phosphate dehydrogenase (G6PD), and lactate dehydrogenase (LDH) were measured in one-cell embryos from X/0 and X/X females. Since the level of both PGK and G6PD was dependent on the number of X chromosomes present in the mother, these two enzymes are most likely coded for by X-linked genes. The level of LDH was the same in both types of embryos, indicating autosomal linkage. A search for an electrophoretic variant of PGK was not successful.

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Author notes

  1. Gordon K. McLean

    Present address: Dartmouth Medical School, Hanover, New Hampshire

Authors and Affiliations

  1. The Jackson Laboratory, Bar Harbor, Maine

    Leslie P. Kozak & Eva M. Eicher

Authors
  1. Leslie P. Kozak
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  2. Gordon K. McLean
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  3. Eva M. Eicher
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Additional information

This research was supported by an allocation (to L. P. K. and E. M. E.) from NIH General Research Support Grant RR-05545 from the Division of Research Resources to The Jackson Laboratory, by a James B. Murphy Memorial Scholarship (to G. K. McL.), by NIH grant HD 06712 from the Institute of Child Health and Human Development (to L.P.K.), and by an allocation from Training Grant GY-9864 (to G.K. McL.) from the National Science Foundation's Undergraduate Research Participation Program. The Jackson Laboratory is fully accredited by the American Association for Accreditation of Laboratory Animal Care.

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Kozak, L.P., McLean, G.K. & Eicher, E.M. X linkage of phosphoglycerate kinase in the mouse. Biochem Genet 11, 41–47 (1974). https://doi.org/10.1007/BF00486618

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  • DOI: https://doi.org/10.1007/BF00486618

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