Abstract
The ratio of total globin α to β chain synthesis was determined in reticulocytes isolated from the blood of the members of a black family, some of whom had sickle cell trait with low blood HbS concentrations (25–30%). The results support the hypothesis that sickle cell trait individuals with low HbS concentrations also carry a gene for α-thalassemia.
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This work was supported by Medical Genetics Center Grant GM 19513 from the National Institute of General Medical Sciences.
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Shaeffer, J.R., DeSimone, J. & Kleve, L.J. Hemoglobin synthesis studies of a family with α-thalassemia trait and sickle cell trait. Biochem Genet 13, 783–788 (1975). https://doi.org/10.1007/BF00484410
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DOI: https://doi.org/10.1007/BF00484410