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Simultaneous determination of nicotine and cotinine in plasma by capillary gas liquid chromatography with nitrogen-sensitive detection

Gleichzeitige Bestimmung von Nicotin und Cotinin in Plasma mit Hilfe der Capillar-Gas-Chromatographie

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  • B Chromatography
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Conclusion

By the use of structural analogues of nicotine and cotinine as internal standards, the elimination of environmental sources of contamination and an exact clean-up procedure, we were able to develop a rapid and sensitive method which has acceptable accuracy and precision over the concentration range necessary in pharmacokinetic studies.

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References

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Authors and Affiliations

  1. Department of Pharmacokinetics and Metabolism, Schwarz Pharma AG, D-4019, Monheim, Federal Republic of Germany

    W. Hammes, J. Bittner & R. F. Müller

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  1. W. Hammes
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  2. J. Bittner
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  3. R. F. Müller
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Hammes, W., Bittner, J. & Müller, R.F. Simultaneous determination of nicotine and cotinine in plasma by capillary gas liquid chromatography with nitrogen-sensitive detection. Z. Anal. Chem. 333, 745–746 (1989). https://doi.org/10.1007/BF00476603

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  • DOI: https://doi.org/10.1007/BF00476603

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