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Lipiodol-Cisplatin embolisation in hepatocellular carcinoma. Radiological techinique and evaluation

  • Original Articles
  • Interventional radiology
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Abstract

In a 1-year period, 14 patients with inoperable, biopsy-proven hepatocellular cacinoma (HCC) underwent 18 superselective catheterisations of the proper hepatic artery with combined injection of Cisplatin and Liodol. According to Okuda et al. [1], patients were classified into clinical Stages I (2), II (7) and III (5). All 5 Stage III patients died during follow-up. Distal superselective catheterisation of the proper hepatic artery, in order to avoid Lipiodol embolism to the gastroduodenal, gastric or other anastomotic arteries was possible with conventional diagnostic catheters use and inexpensive coaxial (5 cases) or, an easry-to-use an inexpensive coaxial catheterisation system (13 cases). Radiological follow-up was by means of computed tomography (CT) 24 h and 6 weeks after chemoembolisation. Further CT studies were performed depending on the patient's progress. Twelve patients had CT follow-up over at least 6 weeks. Hypervascular hepatocellular carcinomas tend to diminish in volume, especially those which retain Lipiodol after 6 weeks, and survival after intra-arterial chemotheraphy is shorter in patients with hypovascular tumours which do not retain Lipiodol. We have treated only a limited number of patients, but consider chemoembolisation okf inoperable HCC with Lipiodol and Cisplatin as useful treatment for Okuda Stage 1 and II patients, but not for those in Stage III. Hypervascularity and Lipiodol retention on follow-up CT could indicate a favourable prognosis.

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Authors and Affiliations

  1. Departments of Radiology, University Hospital K. U. Leuven, Herestraat 49, B-3000, Leuven, Belgium

    P. Peene, G. Wilms, A. L. Baert, L. Stockx, G. Marchal & H. Rigauts

  2. Departments of Radiology, Sint Elisabeth Hospital, Defrélaas 2006, B-1180, Brussels, Belgium

    P. Matthys

  3. Departments of Hepatology, University Hospital K. U. Leuven, Herestraat 49, B-3000, Leuven, Belgium

    W. Van Sttenbergen, Y. Breysem & J. Fevery

  4. Departments of Gastroenterology, Sint Elisabeth Hispital, Defrélaan 206, B-1180, Brussels, Belgium

    J. Van Isveldt

Authors
  1. P. Peene
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  2. G. Wilms
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  3. A. L. Baert
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  4. L. Stockx
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  5. G. Marchal
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  6. H. Rigauts
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  7. P. Matthys
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  8. W. Van Sttenbergen
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  10. J. Van Isveldt
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  11. J. Fevery
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Peene, P., Wilms, G., Baert, A.L. et al. Lipiodol-Cisplatin embolisation in hepatocellular carcinoma. Radiological techinique and evaluation. Eur. Radiol. 1, 131–138 (1991). https://doi.org/10.1007/BF00451296

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