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Analgesic effect of Δ9-tetrahydrocannabinol in the dog

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Abstract

Electrical stimulation of the tooth of the dog has demonstrated that δ 9-tetrahydrocannabinol (1 mg/kg) produces analgesia. Daily administrations cause tolerance to this effect in 8 days. The nature of the analgesia induced by THC is discussed.

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References

  • Burnstein, S., Raz, A.: Inhibition of prostaglandin E2 biosynthesis by δ 9-tetrahydrocannabinol. Prostanglandins 2, 369–347 (1972)

    Google Scholar 

  • Buxbaum, D. M.: Analgesic activity of δ 9-tetrahydrocannabinol in the rat and mouse. Psychopharmacologia (Berl.) 25, 275–280 (1972)

    Google Scholar 

  • Bicher, H. J., Mechoulam, R.: Pharmacological effects of two active constituents of marihuana. Arch. int. Pharmacodyn. 172, 24–31 (1968)

    Google Scholar 

  • Chin, J. E., Domino, E. F.: Effects of morphine on brain potentials evoked by stimulation of the tooth pulp of the dog. J. Pharmacol. exp. Ther. 132, 74–86 (1961)

    Google Scholar 

  • Chopra, G. S.: Man and marihuana. Int. J. Addict. 4, 215–247 (1969)

    Google Scholar 

  • Deneau, G. A., KaymakÇalan, S.: Physiological and psychological dependence to synthetic δ 9-tetrahydrocannabinol (THC) in rhesus monkeys. Pharmacologist 13, 246 (1971)

    Google Scholar 

  • Dewey, W. L., Jenkins, J., O'Rourke, T., Harris, L. S.: Trans-δ 9-tetrahydrocannabinol on behavior and the cardiovascular system of dogs. Arch. int. Pharmacodyn. 198, 118–131 (1972)

    Google Scholar 

  • Gallager, D. W., Sanders-Bush, E., Sulser, F.: Dissociation between behavioral effects and changes in metabolism of cerebral serotonin following δ 9-tetrahydrocannabinol. Psychopharmacologia (Berl.) 26, 337 (1972)

    Google Scholar 

  • KaymakÇalan, S., Deneau, G. A.: Some pharmacological effects of synthetic δ 9-tetrahydrocannabinol (THC). Pharmacologist 13, 247 (1971)

    Google Scholar 

  • KaymakÇalan, S., Deneau, G. A.: Some pharmacologic properties of synthetic δ 9-tetrahydrocannabinol. Acta Medica Turcica, suppl. 1, pp. 1–27. Ankara: Güzel Istanbul Press 1972

    Google Scholar 

  • KaymakÇalan, S.: Physiological and psychological dependence on THC in rhesus monkeys. In: Cannabis and its derivatives. W. D. M. Paton and June Crown, Eds., pp. 142–149. London: Oxford University Press 1972

    Google Scholar 

  • McMillan, D. E., Dewey, W. L., Harris, L. S.: Characteristics of tetrahydrocannabinol tolerance. Ann. N. Y. Acad. Sci. 191, 83–95 (1971)

    Google Scholar 

  • Türker, M. N., Türker, R. K.: Analgesic action of lidoflazine (R 7904). Europ. J. Pharmacol. 11, 90–95 (1970)

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, Ankara University Medical School and School of Dentistry of Ankara University, Sihhiye, Ankara

    Şükrü KaymakÇalan, R. Kâzim Türker & Mustafa N. Türker

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  1. Şükrü KaymakÇalan
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  2. R. Kâzim Türker
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  3. Mustafa N. Türker
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KaymakÇalan, Ş., Türker, R.K. & Türker, M.N. Analgesic effect of Δ9-tetrahydrocannabinol in the dog. Psychopharmacologia 35, 123–128 (1974). https://doi.org/10.1007/BF00429579

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  • DOI: https://doi.org/10.1007/BF00429579

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