Abstract
Effects of intravenously given alcohol on eye movements were analysed in ten voluntary subjects. Each subject served as his/her own control.
Good correlations were found between the changes in saccade variables and subjective evaluations of alertness, eye movement control and intoxication. Interindividually, the subjective evaluation of drunkenness correlates with the alcohol effect on saccade variables better than do the other subjective variables or blood or breath alcohol concentrations.
A steady decrease of mean and maximum velocity and a steady increase in the duration of saccades was observed during the alcohol infusion. The latency of saccades also increased. There was, however, a slight decrease of latency due to alcohol 15 min after the start of infusion, suggesting a biphasic effect of alcohol on saccade latency.
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References
Aantaa E, Virolainen E (1978) Alkohol und Gleichgewichtsstörungen. Arch Otolaryngol 221:197
Baloh RW, Sills AW, Kumley WE, Honrubia V (1975) Quantitative measurement of saccade amplitude, duration, and velocity. Neurology (Minneap) 25:1065–1070
Collins WE (1980) Performance effects of alcohol intoxication and hangover at ground level and at simulated altitude. Aviat Space Environ Med 51 (4):327–335
Ekman G, Frankenhaeuser M, Goldberg L, Hagdahl R, Myrsten A-L (1964) Subjective and objective effects of alcohol as functions of dosage and time. Psychopharmacologia 6:399–409
Franck MC, Kuhlo W (1970) Die Wirkung des Alkohols auf die raschen Blickzielbewegungen (Saccade) beim Menschen. Arch Psychiatr Nervenkr 213:238–245
Guedry FE Jr, Gilson RD, Schroeder DJ, Collins WE (1975) Some effects of alcohol on various aspects of oculomotor control. Aerosp Med 46:1008–1013
Hari R (1979) Biphasic effects of ethanol on behavioral and electrophysiological parameters can be explained by functional organization of neural networks. T.-I.-T.J. Life Sci 9:15–17
Henriksson NG, Pyykkö I, Schalén L, Wennmo C (1980) Velocity patterns of rapid eye movements. Acta Otolaryngol 89:504–512
Kalant H (1975) Direct effect of ethanol on the nervous system. Fed Proc 34:1930–1941
Lang AH, Jäntti V, Lehtinen I, Keskinen E, Nyrke T, Pakkanen A (1981) Korrelationen pharmakologischer, subjektiver und elektrophysiologischer Kriterien akuter Alkoholintoxikation. Wiener Zeitschrift für Suchtforschung 4:35–41
Lehtinen I, Lang AH, Jäntti V, Keskinen E (1979) Acute effects of alcohol on saccadic eye movements. Psychopharmacology 63:17–23
Lehtinen I, Lang AH, Jäntti V, Pakkanen A, Keskinen E, Nyrke T, Lempiäinen M (1981) Ethanol-induced disturbance in human arousal mechanism. Psychopharmacology 73:223–229
Lehtinen I, Nyrke T, Lang AH, Pakkanen A, Keskinen E (1982) Quantitative effects of ethanol infusion on smooth pursuit eye movements in man. Psychopharmacology 77:74–80
Myrsten A-L, Hollstedt C, Holmberg L (1975) Alcohol-induced change in mood and activation in males and females as related to catecholamine excretion and blood-alcohol level. Scand J Psychol 16:303–310
Perrin RG, Hockman CH, Kalant H, Livingston KE (1974) Acute effects of ethanol on spontaneous and auditory evoked electrical activity in cat brain. Electroencephalogr Clin Neurophysiol 36:19–31
Robinson DA (1975) Oculomotor control signals. In: Lennerstrand G, Bach-y-Rita P (eds) Basic mechanisms of ocular motility and their clinical implications. Pergamon Press, Oxford
Umeda Y, Sakata E (1978) Alcohol and the oculomotor system. Ann Otol 87:392–398
Vogel-Sprott MD (1979) Acute recovery and tolerance to low doses of alcohol: Differences in cognitive and motor skill peformance. Psychopharmacology 61:287–291
Vuchinich RE, Sobell MB (1978) Empirical separation of physiologic and expected effects of alcohol on complex perceptual motor performance. Psychopharmacology 60:81–85
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Jäntti, V., Lang, A.H., Keskinen, E. et al. Acute effects of intravenously given alcohol on saccadic eye movements and subjective evaluations of intoxication. Psychopharmacology 79, 251–255 (1983). https://doi.org/10.1007/BF00427822
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DOI: https://doi.org/10.1007/BF00427822