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The effects of different doses of methylpentynol on escape/avoidance conditioning in two strains of rats selectively bred for high and low “emotionality”

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Summary

Animals from strains selectively inbred for high and low emotionality have been administered varying doses of methylpentynol and then subjected to a discrete escape/avoidance task (buzzer-shock). Results indicate an initial increase in avoidance scores associated with dose level followed by a decrease. There is also a clear “dose” and “strain” effect. No direct difference between the sexes was noted but there is a strong “sex X strain” interaction. The usual superiority of the non-emotional strain on tasks of this type of conditioning is reversed by the drug. The possible biphasic and dual effect of methylpentynol is discussed.

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Authors and Affiliations

  1. Animal Psychology Laboratory, Institute of Psychiatry, London

    H. C. Holland & B. D. Gupta

  2. Animal Laboratory Bethlem Royal Hospital Monks Orchard, Beckenham, Kent, Great Britain

    H. C. Holland

Authors
  1. H. C. Holland
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  2. B. D. Gupta
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Additional information

We are indebted to The Nicholas Research Institute Ltd., Slough for the supply of “Oblivon” used throughout this experiment and for the partial financial support of one of us, B.D.G.

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Holland, H.C., Gupta, B.D. The effects of different doses of methylpentynol on escape/avoidance conditioning in two strains of rats selectively bred for high and low “emotionality”. Psychopharmacologia 9, 419–425 (1966). https://doi.org/10.1007/BF00406451

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  • DOI: https://doi.org/10.1007/BF00406451

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