Summary
Male and female rats of Reactive and Non-Reactive strains were injected with either 0.8 mg/kg dose of nicotine bitartrate, 1.0 mg/kg dose of picrotoxin, 10.00 mg/kg dose of penterbarbital sodium or distilled water before each daily trial. Nicotine and picrotoxin facilitated rearing activity whereas pentobarbital sodium inhibited it. The Non-Reactive rats feared more than the Reactive animal. Male rats were found to have higher rearing scores than the females.
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References
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The experimental work was done at the Institute of Psychiatry, London, under the supervision of Dr. H. C. Holland.
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Garg, M. The effects of some central nervous system stimulant and depressant drugs on rearing activity in rats. Psychopharmacologia 14, 150–156 (1969). https://doi.org/10.1007/BF00403688
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DOI: https://doi.org/10.1007/BF00403688