Skip to main content
SpringerLink
Log in

Standard reference materials (SRM's) for measuring genetic damage

  • Standards In Biotechnology
  • Published:
Fresenius' Journal of Analytical Chemistry Aims and scope Submit manuscript

Summary

Standard reference materials were designed for the measurement of radiolytic products resulting from OH radical reaction with DNA in patients treated by radiation therapy. Deuterated thymine glycol and thymidine glycol are proposed as such SRM's; the synthesis of the former is described in detail. They might be of importance for optimising the therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bergtold DS, Simic MG, Alessio H, Gutler RG (1988) Urine biomarkers for oxidative DNA damage. In: Simic MG, Taylor KA, Ward JF, von Sonntag C (eds) Oxygen radicals in biology of medicine. Plenum Press, New York, pp. 483–490

    Google Scholar 

  2. Simic M, Bergtold DS (1990) New approaches in biological dosimetry: urine biomarkers. In: Ricks RC, Fry SA, Lushbaugh CC (eds) The medical basis for radiation accident preparedness, in press

  3. Simic MG, Bergtold DS, Karam LR (1989) Mutat Res 214:3–12

    Google Scholar 

  4. von Sonntag C (1987) The chemical basis of radiation biology, Taylor and Francis, New York

    Google Scholar 

  5. Jovanovic SV, Simic MG (1986) J Am Chem Soc 108:5968–5972

    Google Scholar 

  6. Simic MG, Jovanovic SV (1986) Free radical mechanisms of DNA base damage. In: Simic MG, Grossman L, Upton AC (eds) Mechanisms of DNA damage and repair. Plenum Press, New York

    Google Scholar 

  7. Simic MG (1989) Mutat Res 202:377–386

    Google Scholar 

  8. Friedberg EC (1985) Freeman & Co., New York, DNA repair

  9. Dizdaroglu M, Bergtold DS (1986) Anal Biochem 156:182–188

    Google Scholar 

  10. Cathcart R, Schwiers E, Saul RL, Ames BN (1984) Proc Natl Acad Sci USA 81:5633–5637

    Google Scholar 

  11. Cundy KC, Kohen R, Ames BN (1988) Determination of 8-hydroxydeoxyguanosine in human urine: A possible assay for in vivo oxidative DNA damage. In: Simic MG, Taylor KA, Ward JF, von Sonntag C (eds) Oxygen radicals in biology and medicine. Plenum Press, New York, pp 479–482

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. National Institute of Standards and Technology, 20899, Gaithersburg, MD, USA

    David S. Bergtold, Eric Holwitt & Michael G. Simic

Authors
  1. David S. Bergtold
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eric Holwitt
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael G. Simic
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Bergtold, D.S., Holwitt, E. & Simic, M.G. Standard reference materials (SRM's) for measuring genetic damage. Fresenius J Anal Chem 338, 383–385 (1990). https://doi.org/10.1007/BF00322499

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00322499

Keywords

Search

Navigation