Abstract
Mitotic recombination in satellite stalks — a phenomenon often difficult to distinguish from satellite association — was studied in a sister and a brother with Bloom's syndrome. Segregation after recombination was analyzed in the lymphocytes of the sister who had Q-bright satellites. Her cells varied greatly both in regard to the acrocentrics which displayed Q-bright satellites and the number of such satellites per cell. In 58 cells a total of 31 different patterns were seen. In 83 cells of 6 controls who also had Q-bright satellites on at least one acrocentric chromosome, not one cell was found in which the pattern differed from that characteristic of the person. Obviously exchanges between satellite stalks in patients with Bloom's syndrome are fairly frequent (estimated lower limit 6/1000) and very rare in persons who do not have this syndrome (estimated 0.1/1000).
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References
Festa, R.S., Meadows, A.T., Boshes, R.A.: Leukemia in a black child with Bloom's syndrome. Cancer 44, 1507–1510 (1979)
German, J.: Cytological evidence for crossing-over in vitro in human lymphoid cells. Science 144, 298–301 (1964)
German, J.: Bloom's syndrome. I. Genetical and clinical observations in the first twenty-seven patients. Amer. J. hum. Genet. 21, 196–227 (1969)
German, J., Crippa, L.P., Bloom, D.: Bloom's syndrome. III. Analysis of chromosome aberration characteristic of this disorder. Chromosoma (Berl.) 48, 361–366 (1974)
Knudson, A.G.: Mutation and human cancer. Advanc. Cancer Res. 17, 317–352 (1973)
Kuhn, E.M.: Nonrandom localization of mitotic crossing-over in Bloom's syndrome. Genetics 77, s37-s38 (1974)
Kuhn, E.M.: Localization by Q-banding of mitotic chiasmata in cases of Bloom's syndrome. Chromosoma (Berl.) 57, 1–11 (1976)
Kuhn, E.M.: Mitotic chiasmata and other quadriradials in mitomycin C-treated Bloom's syndrome lymphocytes. Chromosoma (Berl.) 66, 287–297 (1978)
Kuhn, E.M.: Effects of X-irradiation in G1 and G2 on Bloom's syndrome and normal chromosomes. Hum. Genet. 54, 335–341 (1980)
Passarge, E., Bartram, C.R.: Somatic recombination as possible prelude to malignant transformation. Birth Defects: Original Article Series 12, 177–180 (1976)
Patau, K., Therman, E.: Mitotic crossing-over in man. Genetics 61, s45-s46 (1969)
Schroeder, T.M., German, J.: Bloom's syndrome and Fanconi's anemia: Demonstration of two distinctive patterns of chromosome disruption and rearrangement. Humangenetik 25, 299–306 (1974)
Szalay, G.C., Weinstein, E.D.: Questionable Bloom's syndrome in a Negro girl. Amer. J. Dis. Child. 124, 245–248 (1972)
Therman, E., Denniston, C., Sarto, G.E.: Mitotic chiasmata in human diplochromosomes. Hum. Genet. 45, 131–135 (1978)
Therman, E., Kuhn, E.M.: Cytological demonstration of mitotic crossing-over in man. Cytogenet. Cell Genet. 17, 254–267 (1976)
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Therman, E., Otto, P.G. & Shahidi, N.T. Mitotic recombination and segregation of satellites in Bloom's syndrome. Chromosoma 82, 627–636 (1981). https://doi.org/10.1007/BF00285772
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DOI: https://doi.org/10.1007/BF00285772