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Carcinogenicity of N-nitrosopyrrolidine: Dose-response study in rats

Leber-Krebs-Raten bei Nitrosopyrrolidin: Dosis-Wirkungs-Untersuchung an Ratten

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Summary

Results from a dose-response study in rats are reported, in which daily oral doses of 10, 3, 1, and 0.3 mg/kg bodyweight/day respectively were administered. The three highest dose levels resulted in incidences of liver cancer of 46, 84, and 32% respectively. In the lowest dose group (0.3 mg/kg/ day) no statistically significant increase in tumor rate compared to untreated controls was found.

Zusammenfassung

Ergebnisse einer Dosis-Wirkungs-Untersuchung an Ratten werden berichtet, bei welcher tägliche orale Dosen von 10, 3, 1 bzw. 0,3 mg/kg/Tag gegeben wurden. Bei den drei höchsten Dosis-Gruppen ergaben sich Leber-Krebs-Raten von 46, 84 bzw. 32%. In der Dosis-Gruppe mit 0,3 mg/kg/Tag konnte keine statistisch signifikante Erhöhung der Tumorrate im Vergleich zu unbehandelten Kontrollen beobachtet werden.

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Authors and Affiliations

  1. Institute of Toxicology and Chemotherapy, German Cancer Research Center, Im Neuenheimer Feld 280, D-6900, Heidelberg, Federal Republic of Germany

    R. Preussmann, D. Schmähl & G. Eisenbrand

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  1. R. Preussmann
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  2. D. Schmähl
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  3. G. Eisenbrand
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Preussmann, R., Schmähl, D. & Eisenbrand, G. Carcinogenicity of N-nitrosopyrrolidine: Dose-response study in rats. Z. Krebsforsch. 90, 161–166 (1977). https://doi.org/10.1007/BF00285322

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  • DOI: https://doi.org/10.1007/BF00285322

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