Summary
In three urological predictors, nocturia, prostatic surgery for prostatic hypertrophy and a previous venereal disease, a significantly increased relative risk (RR) of developing bladder cancer was detected. An epidemiological casecontrol investigation was performed on 165 male bladder cancer patients and an equal number of male controls matched concerning age and geographical area. The sample was obtained from a predominantly rural district. The theoretical individual risk factors were calculated by the aid of a multivariate logistic analysis. Twenty-four patients versus 11 control had a history of prostatic surgery (RR=2.38) for benign prostatic hypertrophy, 60 patients versus 36 controls complained of nocturial at least 2 years before presenting symptoms of bladder cancer (RR=2.05), and 16 patients versus seven controls had a history of venereal disease (RR=2.42). The results seems to indicate that prostatic hypertrophy and previous venereal disease may at least in part be factors of importance associated with bladder cancer.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Bishop YMM, Fienberg SE, Holland PW (1977) Discrete multivariate analysis. Theory and practice. The MIT Press, Cambridge
Christoffersen I, Møller I (1981) Excretory urography: A superfluous routine examination in patients with prostatic hypertrophy. Eur Urol 7:65
Cole P (1979) The evolving case-control study. J Chron Dis 32:15
Dunham LJ, Rabson AS, Stewart HL, Frank AS, Young JL (1968) Rates, interview, and pathology study of cancer of the urinary bladder in New Orleans, Louisiana. JNCI 41:683
Fellows GJ (1978) The association between vesical carcinoma and urinary obstruction. Eur Urol 4:187
Howe GR, Burch JD, Miller AB, Cook GM, Esteve J, Morrison B, Gordon P, Chambers LW, Fodor G, Winsor GM (1980) Tobacco use, occupation, coffee, various nutrients and bladder cancer. JNCI 64:701
Meyhoff HH, Hald T (1978) Are doctors able to assess prostatic size. Scand J Urol Nephrol 12:219
Mommsen S, Aagaard J, Sell A (in press) An epidemiological case-control study of bladder cancer in males from a predominantly rural district. Eur J Cancer Clin Oncol
Mommsen S, Aagaard J, Sell A (in press) Presenting symptoms, delay and survival of bladder cancer patients. Scand J Urol Nephrol
Mommsen S, Jacobsen F (1982) Flat intraepithelial carcinoma in situ per se in the bladder. Symptoms and course of the disease in four patients. Ugeskr Laeg 144:1078
Mommsen S, Aagaard J, Sell A The epidemiology of female bladder cancer in a predominantly rural district. Submitted to Eur J Cancer Clin Oncol
Pinck DD, Corrigan MJ, Jasper P (1980) Pre-prostatectomy excretory urography: Does it merit the expense? J Urol 123:390
Schade ROK, Swinney J (1968) Pre-cancerous changes in bladder epithelium. Lancet II:943
Unpublished. Available at the Institute of Social Medicine, University of Aarhus, Denmark
Wallace DM (1959) Tumours of the bladder. In: Smithers DW (ed) Monographs on neoplastic disease. Livingstone, Edinburgh
Wynder EL, Onderdonk J, Mantel N (1963) An epidemiological investigation of cancer of the bladder. Cancer 16:1388
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mommsen, S., Sell, A. Prostatic hypertrophy and venereal disease as possible risk factors in the development of bladder cancer. Urol. Res. 11, 49–52 (1983). https://doi.org/10.1007/BF00256946
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00256946