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Myo-inositol-1-phosphate synthase from streptomyces griseus (Studies on the biosynthesis of cyclitols, XXXVIII1)

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Summary

It could be shown that Streptomyces griseus, the microorganism producing the antibiotic streptomycin and also mutant strains of this species that cannot synthesize streptomycin, possess myo-inositol-1-phosphate synthase (EC 5.5.1.4), the enzyme cyclizing D-glucose 6-phosphate. The enzyme isolated from that organism is extremely instable, its molecular weight is approximately 260,000, and it requires a divalent metal ion for its activity. This is the first instance that an enzyme of this specificity has been found in a prokaryotic organism.

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Authors and Affiliations

  1. Shemyakin Institute for Bio-Organic Chemistry, USSR Academy of Sciences, Moscow, USSSR

    Fritz Pittner, Irina I. Tovarova, Elena Ya. Kornitskaya, Aleksander S. Khokhlov & Otto Hoffmann-Ostenhof

  2. Institut für Allgemeine Biochemie der Universität Wien, Vienna, Austria

    Fritz Pittner, Irina I. Tovarova, Elena Ya. Kornitskaya, Aleksander S. Khokhlov & Otto Hoffmann-Ostenhof

  3. Ludwig Boltzmann-Forschungsstelle für Biochemie, Vienna, Austria

    Fritz Pittner, Irina I. Tovarova, Elena Ya. Kornitskaya, Aleksander S. Khokhlov & Otto Hoffmann-Ostenhof

Authors
  1. Fritz Pittner
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  2. Irina I. Tovarova
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  3. Elena Ya. Kornitskaya
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  4. Aleksander S. Khokhlov
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  5. Otto Hoffmann-Ostenhof
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Pittner, F., Tovarova, I.I., Kornitskaya, E.Y. et al. Myo-inositol-1-phosphate synthase from streptomyces griseus (Studies on the biosynthesis of cyclitols, XXXVIII1). Mol Cell Biochem 25, 43–46 (1979). https://doi.org/10.1007/BF00211140

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  • DOI: https://doi.org/10.1007/BF00211140

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