Skip to main content
SpringerLink
Log in

A possible example of gene conversion with a common β-thalassemia mutation and Chi sequence present in the β-globin gene

  • Letters to the Editors
  • Published:
Human Genetics Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  • Antonarakis SE, Orkin SH, Kazazian HH Jr, Goff SC, Boehm CD, Waber PG, Sexton JP, Oster H, Fairbanks VF, Chakravarti A (1982) Evidence for multiple origins of the βE-globin gene in Southeast Asia. Proc Natl Acad Sci USA 79:6608–6611

    Google Scholar 

  • Antonarakis SE, Boehm CD, Serjeant GR, Theisen CE, Dover GJ, Kazazian HH Jr (1984) Origin of the βS-globin gene in Blacks: the contribution of recurrent mutation or gene conversion or both. Proc Natl Acad Sci USA 81:853–856

    Google Scholar 

  • Cheng KC, Smith GR (1987) Cutting of Chi-like sequences by the RecBCD enzyme of Escherichia coli. J Mol Biol 194:747–750

    Google Scholar 

  • Hattori Y, Yamane Y, Yamashiro Y, Matsuno Y, Yamamoto K, Yamamoto Ku, Ohba Y, Miyaji T (1989) Characterization of β-thalassemia mutations among the Japanese. Hemoglobin 13:657–670

    Google Scholar 

  • Kazazian HH Jr, Orkin SH, Markham AF, Chapman CR, Youssoufian H, Waber PG (1984) Quantification of the close association between DNA haplotypes and specific β-thalassemia mutations in Mediterraneans. Nature 310:152–154

    Google Scholar 

  • Kenter AL, Birshtein BK (1981) Chi, a promoter of generalized recombination in λ. phages, is present in immunoglobulin genes. Nature 293:402–404

    Google Scholar 

  • Pirastu M, Galanello R, Doherty MA, Tuveri T, Cao A, Kan YW (1987) The same β-globin gene mutation is present on nine different β-thalassemia chromosomes in a Sardinian population. Proc Natl Acad Sci USA 84:2882–2885

    Google Scholar 

  • Powers PA, Smithies O (1986) Short gene conversion in the human fetal globin gene region: a by-product of chromosome pairing during meiosis? Genetics 112:343–358

    Google Scholar 

  • Smith GR (1983) Chi hotspots of generalized recombination. Cell 34:709–710

    Google Scholar 

  • Stahl FW (1979) Genetic recombination: thinking about it in phage and fungi. Freeman, San Francisco

    Google Scholar 

  • Zhang JZ, Cai SP, He X, Lin HX, Lin HJ, Huang ZG, Chehab FF, Kan YW (1988) Molecular basis of β-thalassemia in South China. Strategy for DNA analysis. Hum Genet 78:37–40

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Laboratory Science, Yamaguchi University School of Medicine, 1144 Kogushi, Ube, 755, Yamaguchi, Japan

    Youko Matsuno, Yasuhiro Yamashiro, Kunimitsu Yamamoto, Yukio Hattori, Kiyomi Yamamoto, Yuzo Ohba & Takaoki Miyaji

Authors
  1. Youko Matsuno
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yasuhiro Yamashiro
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kunimitsu Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yukio Hattori
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Kiyomi Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yuzo Ohba
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Takaoki Miyaji
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Matsuno, Y., Yamashiro, Y., Yamamoto, K. et al. A possible example of gene conversion with a common β-thalassemia mutation and Chi sequence present in the β-globin gene. Hum Genet 88, 357–358 (1992). https://doi.org/10.1007/BF00197277

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00197277

Keywords

Search

Navigation