Skip to main content
SpringerLink
Log in

Animal Models for Probiotic Interventions Under Gut Inflammatory Conditions

  • Chapter
  • First Online:
Probiotic Research in Therapeutics

Abstract

The chapter summarizes the importance of gut microbiota and the relationship between gut microbiota and different inflammatory disease conditions. It also discusses how the commensals and pathogens modulate intestinal barrier functions directly and indirectly, which is the major factor contributing to gut inflammatory disorders. The brain–gut axis involving the hypothalamus–pituitary–adrenal axis and enteric nervous system has a major role in the inflammatory bowel disorder (IBD) pathogenesis. IBD, which is the most common among gut inflammatory disorders, involves a homeostatic imbalance in the microbiota, gut epithelium, and intestinal immune response. This chapter highlights various animal models used to study inflammation related to gut and the management of these pathologies by using different probiotic strains. The probiotics cause immune stimulation through dendritic cells, which further prevents pathogen translocation and strengthens the host immune system. Probiotics, prebiotics, fermentable carbohydrates, and antibiotics are some of the microbiota directed therapies used to modulate host metabolic and immune response in IBD. The most common bacterial strains used in the management of these disorders include Lactobacillus and Bifidobacterium strains which have shown good results in mice model. Understanding the mechanisms involved in disorders related to inflammation in the gut will further help in exploring possible therapies for their management.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Abbreviations

AAD:

Antibiotic-Associated Diarrhea

AMP:

Antimicrobial Peptides

ANS:

Autonomic Nervous System

B-FGF:

Basic Fibroblast Growth Factor

CD:

Cluster of differentiation

CD:

Crohn’s Disease

CDAI:

Crohn’s Disease Activity Index

Cfu:

Colony-forming unit

CG:

Carrageenan

CLA:

Conjugated Linoleic Acid

CNS:

Central nervous system

COX 2:

Cyclooxygenase-2

DAI:

Disease Activity Index

DSS:

Dextran Sulfate Sodium

DUOX:

Dual Oxidase

ENS:

Enteric Nervous System

FAO:

Food and Agriculture Organization

FBD:

Functional Bowel Disorders

FCA:

Freund’s Complete Adjuvant

FMT:

Fecal Microbiota Transplant

GABA:

Gamma aminobutyric acid

GF:

Germ-Free

Gn:

Gnotobiotic

has:

Human Serum Albumin

HPA Axis:

Hypothalamus–Pituitary–Adrenal Axis

Hsp:

Heat Shock Protein

HSV-1:

Herpes Simplex Virus Type 1

IBD:

Inflammatory Bowl Disorder

IFN-γ:

Interferon gamma

IgG1:

Immunoglobulin G1

IL-1:

Interleukins

IPAA:

Ileal Pouch Anal Anastomosis

ISAPP:

International Scientific Association for Probiotics and Prebiotics

ISCs:

Intestinal Stem Cells

JAK/STAT:

Janus Kinase/Signal Transducer and Activator of Transcription

MAPK:

Mitogen-Activated Protein Kinase

MDR:

Multiple Drug Resistant

MHC:

Major histocompatibility complex

NADPH:

Nicotinamide Adenine Dinucleotide Phosphate

NF-Κb:

Nuclear factor kappa-light-chain-enhancer of activated B cells

NOS:

Nitric Oxide Synthase

NPY:

Neuropeptide-Y

PBS:

Phosphate-buffered saline

PG:

Prostaglandins

PML:

Progressive Multifocal Leukoencephalopathy

PUFA:

Polyunsaturated Fatty Acids

ROS:

Reactive Oxygen Species

RT-PCR:

Real Time Polymerase Chain Reaction

SCI:

Spinal Cord Injury

SCID:

Severe combined immunodeficiency

SDF-1:

Stromal Cell-Derivedfactor-1

SSCP:

Single Strand Conformation Polymorphism

STAT-3:

Signal Transducer And Activator Of Transcription 3

TGF-β:

Transforming Growth Factor-β

Th 17:

T Helper Type 17

TLR:

Toll-Like Receptor

TNBS:

Trinitrobenzene Sulfonic Acid

TNF-α:

Tissue Necrotic Factor-α

Tregs:

Regulatory T Cells

UC:

Ulcerative Colitis

VEGF:

Vascular Endothelial Growth Factor

WHO:

World Health Organization

References

  • Al Omran Y, Aziz Q (2014) The brain-gut axis in health and disease. In: Microbial endocrinology: the microbiota-gut-brain axis in health and disease. Springer, pp 135–153

    Google Scholar 

  • Ananthakrishnan ANJCs, 360 C (2020) Impact of Diet on Risk of IBD. 2(1):otz054

    Google Scholar 

  • Apidianakis Y, Rahme LG (2011) Drosophila melanogaster as a model for human intestinal infection and pathology. Dis Models Mech 4(1):21–30

    Article  CAS  Google Scholar 

  • Arab HH, Al-Shorbagy MY, Abdallah DM, Nassar NN (2014) Telmisartan attenuates colon inflammation, oxidative perturbations and apoptosis in a rat model of experimental inflammatory bowel disease. PloS One 9(5):e97193

    Article  PubMed  PubMed Central  Google Scholar 

  • Arboleya S, Watkins C, Stanton C, Ross RPJF (2016) Gut bifidobacteria populations in human health and aging. Front Microbiol 7:1204

    Google Scholar 

  • Arias-Jayo N, Abecia L, Alonso-Sáez L, Ramirez-Garcia A, Rodriguez A, Pardo MAJM (2018) High-fat diet consumption induces microbiota dysbiosis and intestinal inflammation in zebrafish. Microb Ecol 76(4):1089–1101

    Google Scholar 

  • Arvola T, Laiho K, Torkkeli S, Mykkänen H, Salminen S, Maunula L, Isolauri E (1999) Prophylactic lactobacillus GGReduces antibiotic-associated Diarrhea in children with respiratory infections: a randomized study. Pediatrics 104(5):e64–e64

    Article  CAS  PubMed  Google Scholar 

  • Azad MAK, Sarker M, Li T, Yin J (2018) Probiotic species in the modulation of gut microbiota: an overview. BioMed Res Int 2018:9478630. https://doi.org/10.1155/2018/9478630

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bagga D, Reichert JL, Koschutnig K, Aigner CS, Holzer P, Koskinen K, Moissl-Eichinger C, Schöpf V (2018) Probiotics drive gut microbiome triggering emotional brain signatures. Gut Microbes 9(6):486–496

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bailey J, Vince V, Williams N, Cogan T (2017) Streptococcus thermophilus NCIMB 41856 ameliorates signs of colitis in an animal model of inflammatory bowel disease. Benefic Microbes 8(4):605–614

    Article  CAS  Google Scholar 

  • Ballanti E, Conigliaro P, Chimenti MS, Kroegler B, Di Muzio G, Guarino MD, Triggianese P, Gigliucci G, Novelli L, Barbato C (2014) Use of anti-tumor necrosis factor alpha therapy in patients with concurrent rheumatoid arthritis and hepatitis B or hepatitis C: a retrospective analysis of 32 patients. Drug Dev Res 75:S42–S45

    Article  CAS  PubMed  Google Scholar 

  • Barbalho SM, Goulart RDA, Batista GLdSA (2019) Vitamin A and inflammatory bowel diseases: from cellular studies and animal models to human disease. Exp Rev Gastroenterol Hepatol 13(1):25–35

    Google Scholar 

  • Bassaganya-Riera J, Hontecillas R (2006) CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD. Clin Nutr 25(3):454–465

    Article  CAS  PubMed  Google Scholar 

  • Biagi E, Franceschi C, Rampelli S, Severgnini M, Ostan R, Turroni S, Consolandi C, Quercia S, Scurti M, Monti DJCB (2016) Gut microbiota and extreme longevity. Curr Biol 26(11):1480–1485

    Google Scholar 

  • Bin P, Liu S, Chen S, Zeng Z, Huang R, Yin Y, Liu GJA(2017) The effect of aspartate supplementation on the microbial composition and innate immunity on mice. Amino Acids 49(12):2045–2051

    Google Scholar 

  • Bin-Nun A, Bromiker R, Wilschanski M, Kaplan M, Rudensky B, Caplan M, Hammerman C (2005) Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr 147(2):192–196

    Article  PubMed  Google Scholar 

  • Bischoff SCJCOICN, Care M (2016) Microbiota and aging. Curr Opin Clin Nutr Metab Care 19(1):26–30

    Google Scholar 

  • Bjursell MK, Martens EC, Gordon JIJJOBC (2006) Functional genomic and metabolic studies of the adaptations of a prominent adult human gut symbiont, bacteroides thetaiotaomicron, to the suckling period. J Biol Chem 281(47):36269–36279

    Article  CAS  PubMed  Google Scholar 

  • Bourreille A, Cadiot G, Le Dreau G, Laharie D, Beaugerie L, Dupas JL, Marteau P, Rampal P, Moyse D, Saleh A (2013) Saccharomyces boulardii does not prevent relapse of Crohn’s disease. Clin Gastroenterol Hepatol 11(8):982–987

    Article  PubMed  Google Scholar 

  • Bravo JA, Forsythe P, Chew MV, Escaravage E, Savignac HM, Dinan TG, Bienenstock J, Cryan JF (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci 108(38):16050–16055

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bron PA, Van Baarlen P, Kleerebezem M (2012) Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa. Nat Rev Microbiol 10(1):66–78

    Article  CAS  Google Scholar 

  • Brown AC, Valiere AJ (2004) Probiotics and medical nutrition therapy. Nutr Clin Care 7(2):56

    Google Scholar 

  • Brugman S, Nieuwenhuis EE (2017) Oxazolone-induced intestinal inflammation in adult zebrafish. In: Inflammation. Springer, pp 311–318

    Google Scholar 

  • Brugman SJD (2016) The zebrafish as a model to study intestinal inflammation. Dev Comp Immunol 64:82–92

    Google Scholar 

  • Brun P, Scarpa M, Marchiori C, Sarasin G, Caputi V, Porzionato A, Giron MC, Palù G, Castagliuolo IJPO (2017) Saccharomyces boulardii CNCM I-745 supplementation reduces gastrointestinal dysfunction in an animal model of IBS. 12(7)

    Google Scholar 

  • Buchon N, Silverman N, Cherry S (2014) Immunity in Drosophila melanogaster—from microbial recognition to whole-organism physiology. Nat Rev Immunol 14(12):796–810

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Butel MJ (2014) Probiotics, gut microbiota and health. Med Mal Infect 44(1):1–8. https://doi.org/10.1016/j.medmal.2013.10.002

    Article  PubMed  Google Scholar 

  • Cash HL, Whitham CV, Behrendt CL, Hooper LVJS (2006) Symbiotic bacteria direct expression of an intestinal bactericidal lectin. Science 313(5790):1126–1130

    Google Scholar 

  • Chassaing B, Aitken JD, Malleshappa M, Vijay-Kumar MJCPII (2014) Dextran sulfate sodium (DSS)-induced colitis in mice. Sci Rep 104(1):15.25.11-15.25.14

    Google Scholar 

  • Choi E-J, Lee HJ, Kim W-J, Han K-I, Iwasa M, Kobayashi K, Debnath T, Tang Y, Kwak Y-S, Yoon J-H (2019) Enterococcus faecalis EF-2001 protects DNBS-induced inflammatory bowel disease in mice model. PloS One 14(2)

    Google Scholar 

  • Chuang L-S, Morrison J, Hsu N-Y, Labrias PR, Nayar S, Chen E, Villaverde N, Facey JA, Boschetti G, Giri MJD (2019) Zebrafish modeling of intestinal injury, bacterial exposures and medications defines epithelial in vivo responses relevant to human inflammatory bowel disease. 12(8):037432

    Google Scholar 

  • Colombel JF, Sandborn WJ, Rutgeerts P, Enns R, Hanauer SB, Panaccione R, Schreiber S, Byczkowski D, Li J, Kent JDJG (2007) Adalimumab for maintenance of clinical response and remission in patients with Crohn’s disease: the CHARM trial. 132 (1):52-65

    Google Scholar 

  • Cong Y, Brandwein SL, McCabe RP, Lazenby A, Birkenmeier EH, Sundberg JP, Elson CO (1998) CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease. J Exp Med 187(6):855–864

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Conte MP, Schippa S, Zamboni I, Penta M, Chiarini F, Seganti L, Osborn J, Falconieri P, Borrelli O, Cucchiara S (2006) Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease. Gut 55(12):1760–1767. https://doi.org/10.1136/gut.2005.078824

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Danese SJWJOGW (2011) What’s hot in inflammatory bowel disease in 2011? World J Gastroenterol 17(5):545

    Google Scholar 

  • Denis M-C, Roy D, Yeganeh PR, Desjardins Y, Varin T, Haddad N, Amre D, Sané AT, Garofalo C, Furtos AJCS (2016) Apple peel polyphenols: a key player in the prevention and treatment of experimental inflammatory bowel disease. Clin Sci 130(23):2217–2237

    Google Scholar 

  • Din AU, Hassan A, Zhu Y, Zhang K, Wang Y, Li T, Wang Y, Wang G (2020) Inhibitory effect of Bifidobacterium bifidum ATCC 29521 on colitis and its mechanism. J Nutr Biochem 79:108353

    Article  CAS  PubMed  Google Scholar 

  • El Naggar EE, Mohamed EA, Borg TM, El-Sheakh AR, Hamed MF (2020) Colon targeting of naringin for enhanced cytoprotection against indomethacin-induced colitis in rabbits. Drug Design Dev Therapy 14:677

    Article  Google Scholar 

  • El-Salhy M, Hausken TJN (2016) The role of the neuropeptide Y (NPY) family in the pathophysiology of inflammatory bowel disease (IBD). 55:137–144

    Google Scholar 

  • Faber W, Nachtegaal J, Stolwijk-Swuste J, Achterberg-Warmer W, Koning C, Besseling-van der Vaart I, van Bennekom C (2020) Study protocol of a double-blind randomised placebo-controlled trial on the effect of a multispecies probiotic on the incidence of antibiotic-associated diarrhoea in persons with spinal cord injury. Spinal Cord 58(2):149–156

    Article  CAS  PubMed  Google Scholar 

  • Fakhoury M, Negrulj R, Mooranian A, Al-Salami H (2014) Inflammatory bowel disease: clinical aspects and treatments. J Inflammat Res 7:113

    Article  Google Scholar 

  • Feng Q, Liang S, Jia H, Stadlmayr A, Tang L, Lan Z, Zhang D, Xia H, Xu X, Jie ZJNC (2015) Gut microbiome development along the colorectal adenoma–carcinoma sequence. Nat Commun 6:6528

    Google Scholar 

  • Foligne B, Nutten S, Grangette C, Dennin V, Goudercourt D, Poiret S, Dewulf J, Brassart D, Mercenier A, Pot BJWJOGW (2007) Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria. World J Gastroenterol 13(2):236

    Google Scholar 

  • Food JJB, Bulletin P (2008) Guidelines for the evaluation of probiotics in food: report of a joint FAO/WHO working group on drafting guidelines for the evaluation of probiotics in food. World Health Organization Website, London, 2002. 31(11):2121–2125

    Google Scholar 

  • Freedman SB, Williamson-Urquhart S, Farion KJ, Gouin S, Willan AR, Poonai N, Hurley K, Sherman PM, Finkelstein Y, Lee BE (2018) Multicenter trial of a combination probiotic for children with gastroenteritis. New England J Med 379(21):2015–2026

    Article  CAS  Google Scholar 

  • Fujino S, Andoh A, Bamba S, Ogawa A, Hata K, Araki Y, Bamba T, Fujiyama YJG (2003) Increased expression of interleukin 17 in inflammatory bowel disease. Gut 52(1):65–70

    Google Scholar 

  • Fuller R (2012) Probiotics: the scientific basis. Springer Science & Business Media

    Google Scholar 

  • Furness JB (2012) The enteric nervous system and neurogastroenterology. Nat Rev Gastroenterol Hepatol 9(5):286

    Article  CAS  PubMed  Google Scholar 

  • Garcia Vilela E, De Lourdes De Abreu Ferrari M, Oswaldo Da Gama Torres H, Guerra Pinto A, Carolina Carneiro Aguirre A, Paiva Martins F, Marcos Andrade Goulart E, Sales Da Cunha A (2008) Influence of Saccharomyces boulardii on the intestinal permeability of patients with Crohn’s disease in remission. Scandinavian J Gastroenterol 43(7):842–848

    Article  Google Scholar 

  • Ghouri YA, Richards DM, Rahimi EF, Krill JT, Jelinek KA, DuPont AWJC, Gastroenterology E (2014) Systematic review of randomized controlled trials of probiotics, prebiotics, and synbiotics in inflammatory bowel disease. Clin Exp Gastroenterol 7:473

    Google Scholar 

  • Gibson GR, Roberfroid MBJTJON (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr 125(6):1401–1412

    Google Scholar 

  • Gionchetti P, Rizzello F, Helwig U, Venturi A, Lammers KM, Brigidi P, Vitali B, Poggioli G, Miglioli M, Campieri M (2003) Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterology 124(5):1202–1209

    Article  PubMed  Google Scholar 

  • Goodman LS (1996) Goodman and Gilman’s the pharmacological basis of therapeutics, vol 1549. McGraw-Hill, New York

    Google Scholar 

  • Gosselink MP, Schouten WR, van Lieshout LM, Hop WC, Laman JD, Ruseler-van Embden JG (2004) Delay of the first onset of pouchitis by oral intake of the probiotic strain Lactobacillus rhamnosus GG. Dis Colon Rectum 47(6):876–884

    Article  PubMed  Google Scholar 

  • Guo J, Wang LY, Wu J, Xu LF, Sun M (2020) The JAK2 inhibitor AG490 regulates the Treg/Th17 balance and alleviates DSS-induced intestinal damage in IBD rats. Clin Exp Pharmacol Physiol

    Google Scholar 

  • Ha E-M, Lee K-A, Park SH, Kim S-H, Nam H-J, Lee H-Y, Kang D, Lee W-J (2009) Regulation of DUOX by the Gαq-phospholipase Cβ-Ca2+ pathway in Drosophila gut immunity. Dev Cell 16(3):386–397

    Article  CAS  PubMed  Google Scholar 

  • Hammami R, Fernandez B, Lacroix C, Fliss IJC (2013) Anti-infective properties of bacteriocins: an update. Cell Mol Life Sci 70(16):2947–2967

    Google Scholar 

  • Hammer RE, Maika SD, Richardson JA, Tang J-P, Taurog JD (1990) Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human β2m: an animal model of HLA-B27-associated human disorders. Cell 63(5):1099–1112

    Article  CAS  PubMed  Google Scholar 

  • Hanyang L, Xuanzhe L, Xuyang C, Yujia Q, Jiarong F, Jun S, Zhihua RJF (2017) Application of zebrafish models in inflammatory bowel disease. 8:501

    Google Scholar 

  • He M, Shi BJC (2017) Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics. Cell Biosci 7(1):54

    Google Scholar 

  • Heilpern D, Szilagyi A (2008) Manipulation of intestinal microbial flora for therapeutic benefit in inflammatory bowel diseases: review of clinical trials of probiotics, prebiotics and synbiotics. Rev Recent Clin Trials 3(3):167–184

    Article  CAS  PubMed  Google Scholar 

  • Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen SJNRG (2014) Expert consensus document: The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11(8):506–514

    Google Scholar 

  • Holländer GA, Simpson SJ, Mizoguchi E, Nichogiannopoulou A, She J, Gutierrez-Ramos J-C, Shan AK, Burakoff SJ, Wang B, Terhorst C (1995) Severe colitis in mice with aberrant thymic selection. Immunity 3(1):27–38

    Article  PubMed  Google Scholar 

  • Holmes E, Li JV, Athanasiou T, Ashrafian H, Nicholson JK (2011) Understanding the role of gut microbiome–host metabolic signal disruption in health and disease. Trends Microbiol 19(7):349–359

    Google Scholar 

  • Hontecillas R, Wannemeulher MJ, Zimmerman DR, Hutto DL, Wilson JH, Ahn DU, Bassaganya-Riera J (2002) Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid. J Nutr 132(7):2019–2027

    Article  CAS  PubMed  Google Scholar 

  • Hooper L, Littman D, Macpherson A (2012) Interactions between the microbiota and the immune system. Science 336:1268–1273

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hornef MJI (2015) Pathogens, commensal symbionts, and pathobionts: discovery and functional effects on the host. ILAR J 56(2):159–162

    Google Scholar 

  • Huang Y-F, Liu P-Y, Chen Y-Y, Nong B-R, Huang I-F, Hsieh K-S, Chen K-T (2014) Three-combination probiotics therapy in children with salmonella and rotavirus gastroenteritis. J Clin Gastroenterol 48(1):37–42

    Article  PubMed  Google Scholar 

  • Jakobsson HE, Rodríguez-Piñeiro AM, Schütte A, Ermund A, Boysen P, Bemark M, Sommer F, Bäckhed F, Hansson GC, Johansson MEJ (2015) The composition of the gut microbiota shapes the colon mucus barrier. EMBO Rep 16(2):164–177

    Google Scholar 

  • Jiang Y, Yang G, Meng F, Yang W, Hu J, Ye L, Shi C, Wang C (2016) Immunological mechanisms involved in probiotic-mediated protection against Citrobacter rodentium-induced colitis. Benef Microbes 7(3):397–407

    Article  CAS  PubMed  Google Scholar 

  • Jiminez JA, Uwiera TC, Douglas Inglis G, Uwiera RR (2015) Animal models to study acute and chronic intestinal inflammation in mammals. Gut Pathogens 7:29. https://doi.org/10.1186/s13099-015-0076-y

    Article  PubMed  PubMed Central  Google Scholar 

  • Kamada N, Kim Y-G, Sham HP, Vallance BA, Puente JL, Martens EC, Núñez GJS (2012) Regulated virulence controls the ability of a pathogen to compete with the gut microbiota. Science 336(6086):1325–1329

    Google Scholar 

  • Kamil R, Geier MS, Butler RN, Howarth GS (2007) Lactobacillus rhamnosus GG exacerbates intestinal ulceration in a model of indomethacin-induced enteropathy. Dig Dis Sci 52(5):1247–1252

    Article  CAS  PubMed  Google Scholar 

  • Kanai T, Kawamura T, Dohi T, Makita S, Nemoto Y, Totsuka T, Watanabe M (2006) TH1/TH2-mediated colitis induced by adoptive transfer of CD4+ CD45RBhigh T lymphocytes into nude mice. Inflammat Bowel Dis 12(2):89–99

    Article  Google Scholar 

  • Kanazawa S, Tsunoda T, Onuma E, Majima T, Kagiyama M, Kikuchi KJ (2001) VEGF, basic-FGF, and TGF-β in Crohn’s disease and ulcerative colitis: a novel mechanism of chronic intestinal inflammation. Am J Gastroenterol 96 (3):822-828

    Google Scholar 

  • Kaufmann SH (2008) Elie Metchnikoff”s and Paul Ehrlich’s impact on infection biology. 10 (14–15):1417-1419

    Google Scholar 

  • Kiesler P, Fuss IJ, Strober WJC (2015) Experimental models of inflammatory bowel diseases. Cell Mol Gastroenterol Hepatol 1(2):154–170

    Google Scholar 

  • Kim N, Kunisawa J, Kweon M-N, Ji GE, Kiyono H (2007) Oral feeding of Bifidobacterium bifidum (BGN4) prevents CD4+ CD45RBhigh T cell-mediated inflammatory bowel disease by inhibition of disordered T cell activation. Clin Immunol 123(1):30–39

    Article  CAS  PubMed  Google Scholar 

  • Kitazawa H, Villena J, Alvarez S (2013) Probiotics: immunobiotics and immunogenics. CRC Press

    Google Scholar 

  • Kitazawa H, Alvarez S, Suvorov A, Melnikov V, Villena J, Sánchez BJB (2015) Recent advances and future perspective in microbiota and probiotics. Biomed Res Int 2015:275631

    Google Scholar 

  • Ko JS, Yang HR, Chang JY, Seo JK (2007) Lactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-α. World J Gastroenterol 13(13):1962

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Komaki S, Haque A, Miyazaki H, Matsumoto T, Nakamura S (2020) Unexpected effect of probiotics by Lactococcus lactis subsp. lactis against colitis induced by dextran sulfate sodium in mice. J Infect Chemother 26(6):549–553

    Google Scholar 

  • Konturek P, Haziri D, Brzozowski T, Hess T, Heyman S, Kwiecien S, Konturek S, Koziel JJJP (2015) Emerging role of fecal microbiota therapy in the treatment of gastrointestinal and extra-gastrointestinal diseases. 66(4):483–491

    Google Scholar 

  • Kruis W, Frič P, Pokrotnieks J, Lukáš M, Fixa B, Kaščák M, Kamm M, Weismueller J, Beglinger C, Stolte M (2004) Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 53(11):1617–1623

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kumar A, Baruah A, Tomioka M, Iino Y, Kalita MC, Khan M (2019) Caenorhabditis elegans: a model to understand host–microbe interactions. Cell Mol Life Sci:1–21

    Google Scholar 

  • La Fata G, Weber P, Mohajeri MHJP (2018) Probiotics and the gut immune system: indirect regulation. Probiot Antimicrob Prot 10(1):11–21

    Google Scholar 

  • Lakshminarayanan B, Stanton C, O’Toole P, Ross RPJT (2014) Compositional dynamics of the human intestinal microbiota with aging: implications for health. J Nutr Health Aging 18(9):773–786

    Google Scholar 

  • Lanzarotto F, Carpani M, Chaudhary R, Ghosh S (2006) Novel treatment options for inflammatory bowel disease. Drugs 66(9):1179–1189

    Article  CAS  PubMed  Google Scholar 

  • Lebeer S, Vanderleyden J, De Keersmaecker SC (2010) Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens. Nat Rev Microbiol 8(3):171–184

    Article  CAS  PubMed  Google Scholar 

  • LeBlanc JG, Milani C, De Giori GS, Sesma F, Van Sinderen D, Ventura MJC (2013) Bacteria as vitamin suppliers to their host: a gut microbiota perspective. Curr Opin Biotechnol 24(2):160–168

    Google Scholar 

  • Lee W-J, Kim S-H (2014) Role of DUOX in gut inflammation: lessons from Drosophila model of gut-microbiota interactions. Front Cell Infect Microbiol 3:116

    PubMed  PubMed Central  Google Scholar 

  • Lee W-T, Tung Y-T, Wu C-C, Tu P-S, Yen G-C (2018) Camellia oil (Camellia oleifera Abel.) modifies the composition of gut microbiota and alleviates acetic acid-induced colitis in rats. J Agric Food Chem 66(28):7384–7392

    Article  CAS  PubMed  Google Scholar 

  • Li F, Duan K, Wang C, McClain C, Feng WJG (2016) Probiotics and alcoholic liver disease: treatment and potential mechanisms. Gastroenterol Res Pract 2016(6):1-11

    Google Scholar 

  • Li N, Wang Q, Wang Y, Sun A, Lin Y, Jin Y, Li X (2018) Oral probiotics ameliorate the behavioral deficits induced by chronic mild stress in mice via the gut microbiota-inflammation axis. Front Behav Neurosci 12:266

    Article  PubMed  PubMed Central  Google Scholar 

  • Lilly DM, Stillwell RHJS (1965) Probiotics: growth-promoting factors produced by microorganisms. Science 147(3659):747–748

    Google Scholar 

  • MacDonald JK, McDonald JW (2007) Natalizumab for induction of remission in Crohn’s disease. Cochrane Database Syst Rev 1:CD006097

    Google Scholar 

  • Macfarlane GT (1991) The colonic flora, fermentation and large bowel digestive function. 51–92

    Google Scholar 

  • Madara JL, Podolsky DK, King NW, Sehgal PK, Moore R, Winter HS (1985) Characterization of spontaneous colitis in cotton-top tamarins (Saguinus oedipus) and its response to sulfasalazine. Gastroenterology 88(1):13–19

    Article  CAS  PubMed  Google Scholar 

  • Mähler M, Bristol IJ, Leiter EH, Workman AE, Birkenmeier EH, Elson CO, Sundberg JP (1998) Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis. Am J Physiol-Gastrointest Liver Physiol 274(3):G544–G551

    Google Scholar 

  • Manichanh C, Rigottier-Gois L, Bonnaud E, Gloux K, Pelletier E, Frangeul L, Nalin R, Jarrin C, Chardon P, Marteau PJG (2006) Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach. Gut 55 (2):205-211

    Google Scholar 

  • Manichanh C, Borruel N, Casellas F, Guarner F (2012) The gut microbiota in IBD. Nat Rev Gastroenterol Hepatol 9(10):599–608. https://doi.org/10.1038/nrgastro.2012.152

    Article  CAS  PubMed  Google Scholar 

  • Martel-Pelletier J, Welsch DJ, Pelletier J-P (2001) Metalloproteases and inhibitors in arthritic diseases. Best Pract Res Clin Rheumatol 15(5):805–829

    Article  CAS  PubMed  Google Scholar 

  • Matuszyk A, Ceranowicz P, Warzecha Z, Cieszkowski J, Bonior J, Jaworek J, Kuśnierz-Cabala B, Konturek P, Ambroży T, Dembiński A (2016) Obestatin accelerates the healing of acetic acid-induced colitis in rats. Oxidative Med Cellular Longevity 2016

    Google Scholar 

  • McFarland LV (2006) Meta-analysis of probiotics for the prevention of antibiotic associated diarrhea and the treatment of Clostridium difficile disease. Am J Gastroenterol 101(4):812–822

    Article  PubMed  Google Scholar 

  • Mee A, McLaughlin J, Hodgson H, Jewell D (1979) Chronic immune colitis in rabbits. Gut 20(1):1–5

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Menozzi A, Pozzoli C, Poli E, Martelli M, Martelli L, Zullian C, Bertini S (2009) Effects of oral curcumin on indomethacin-induced small intestinal damage in the rat. Drug Discov Therapeut 3(2)

    Google Scholar 

  • Messaoudi M, Lalonde R, Violle N, Javelot H, Desor D, Nejdi A, Bisson J-F, Rougeot C, Pichelin M, Cazaubiel M (2011) Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects. Br J Nutr 105(5):755–764

    Article  CAS  PubMed  Google Scholar 

  • Mi Y, Chin YX, Cao WX, Chang YG, Lim PE, Xue CH, Tang QJ (2020) Native κ-carrageenan induced-colitis is related to host intestinal microecology. Int J Biol Macromol

    Google Scholar 

  • Miller MJ, Thompson JH, Zhang X-J, Sadowska-Krowicka H, Kakkis JL, Munshi UK, Sandoval M, Rossi JL, Eloby-Childress S, Beckman JS (1995) Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitis. Gastroenterology 109(5):1475–1483

    Article  CAS  PubMed  Google Scholar 

  • Mullin GE, Lazenby AJ, Harris ML, Bayless TM, James SPJG (1992) Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn’s disease but not ulcerative colitis. Gastroenterology 102 (5):1620–1627

    Google Scholar 

  • Munyaka PM, Sepehri S, Ghia J-E, Khafipour E (2016) Carrageenan gum and adherent invasive Escherichia coli in a piglet model of inflammatory bowel disease: impact on intestinal mucosa-associated microbiota. Front Microbiol 7:462

    Article  PubMed  PubMed Central  Google Scholar 

  • Nelson SM, Nguyen TM, McDonald JW, MacDonald JK (2018) Natalizumab for induction of remission in Crohn’s disease. Inflamm Bowel Dis 8

    Google Scholar 

  • Ni J, Wu GD, Albenberg L, Tomov VT (2017) Gut microbiota and IBD: causation or correlation? Nat Rev Gastroenterol Hepatol 14(10):573

    Google Scholar 

  • Nobili V, Putignani L, Mosca A, Del Chierico F, Vernocchi P, Alisi A, Stronati L, Cucchiara S, Toscano M, Drago LJ (2018) Bifidobacteria and lactobacilli in the gut microbiome of children with non-alcoholic fatty liver disease: which strains act as health players? Arch Med Sci 14(1):81

    Google Scholar 

  • O’Shea JJ (1997) Jaks, STATs, cytokine signal transduction, and immunoregulation: are we there yet? Immunity 7(1):1–11

    Article  PubMed  Google Scholar 

  • Oehlers SH, Flores MV, Hall CJ, Wang L, Ko DC, Crosier KE, Crosier PS (2017) A whole animal chemical screen approach to identify modifiers of intestinal neutrophilic inflammation. FEBS J 284(3):402–413

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Oka A, Sartor RB (2020) Microbial-based and microbial-targeted therapies for inflammatory bowel diseases. Dig Dis Sci 1–32

    Google Scholar 

  • Olivares M, Díaz-Ropero MP, Gómez N, Lara-Villoslada F, Sierra S, Maldonado JA, Martín R, López-Huertas E, Rodríguez JM, Xaus J (2006) Oral administration of two probiotic strains, Lactobacillus gasseri CECT5714 and Lactobacillus coryniformis CECT5711, enhances the intestinal function of healthy adults. Int J Food Microbiol 107(2):104–111

    Article  PubMed  Google Scholar 

  • Østensen M, Khamashta M, Lockshin M, Parke A, Brucato A, Carp H, Doria A, Rai R, Meroni P, Cetin I (2006) Anti-inflammatory and immunosuppressive drugs and reproduction. Arthritis Res Therapy 8(3):209

    Article  Google Scholar 

  • Ott S, Musfeldt M, Wenderoth D, Hampe J, Brant O, Fölsch U, Timmis K, Schreiber S (2004) Reduction in diversity of the colonic mucosa associated bacterial microflora in patients with active inflammatory bowel disease. Gut 53(5):685–693

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Panwala CM, Jones JC, Viney JL (1998) A novel model of inflammatory bowel disease: mice deficient for the multiple drug resistance gene, mdr1a, spontaneously develop colitis. J Immunol 161(10):5733–5744

    Article  CAS  PubMed  Google Scholar 

  • Papalini S, Michels F, Kohn N, Wegman J, van Hemert S, Roelofs K, Arias-Vasquez A, Aarts E (2019) Stress matters: randomized controlled trial on the effect of probiotics on neurocognition. Neurobiol Stress 10:100141

    Article  CAS  PubMed  Google Scholar 

  • Park J-S, Choi J, Kwon JY, Jung K-A, Yang CW, Park S-H, Cho M-L (2018) A probiotic complex, rosavin, zinc, and prebiotics ameliorate intestinal inflammation in an acute colitis mouse model. J Transl Med 16(1):37. https://doi.org/10.1186/s12967-018-1410-1

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Park SC, Jeen YT (2018) Anti-integrin therapy for inflammatory bowel disease. World J Gastroenterol 24(17):1868

    Google Scholar 

  • Pawar A, Anap R, Ghodasara J, Kuchekar B (2011) Protective effect of hydroalcoholic root extract of Rubia cordifolia in indomethacin-induced enterocolitis in rats. Indian J Pharm Sci 73(2):250

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pellissier S, Bonaz B (2017) The place of stress and emotions in the irritable bowel syndrome. In: Vitamins and hormones, vol 103. Elsevier, pp 327–354

    Google Scholar 

  • Peña JA, Rogers AB, Ge Z, Ng V, Li SY, Fox JG, Versalovic J (2005) Probiotic Lactobacillus spp. diminish Helicobacter hepaticus-induced inflammatory bowel disease in interleukin-10-deficient mice. Infect Immunity 73(2):912–920

    Article  Google Scholar 

  • Perez Martinez G, Bäuerl C, Collado MJBM (2014) Understanding gut microbiota in elderly’s health will enable intervention through probiotics. Benef Microbes 5(3):235–246

    Google Scholar 

  • Podolsky DK, Lobb R, King N, Benjamin CD, Pepinsky B, Sehgal P, DeBeaumont M (1993) Attenuation of colitis in the cotton-top tamarin by anti-alpha 4 integrin monoclonal antibody. J Clin Investigat 92(1):372–380

    Article  CAS  Google Scholar 

  • Pope JL, Tomkovich S, Yang Y, Jobin CJTR(2017) Microbiota as a mediator of cancer progression and therapy. Transl Res 179:139–154

    Google Scholar 

  • Pukkila-Worley R, Ausubel FM (2012) Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium. Curr Opin Immunol 24(1):3–9

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pütsep K, Axelsson L-G, Boman A, Midtvedt T, Normark S, Boman HG, Andersson MJ (2000) Germ-free and colonized mice generate the same products from enteric prodefensins. J Biol Chem 275(51):40478–40482

    Google Scholar 

  • Quaresma M, Damasceno S, Monteiro C, Lima F, Mendes T, Lima M, Justino P, Barbosa A, Souza M, Souza EJN (2019) Probiotic mixture containing Lactobacillus spp. and Bifidobacterium spp. attenuates 5-fluorouracil-induced intestinal mucositis in mice. 1–11

    Google Scholar 

  • Rabah H, Do Carmo FLR, Carvalho RD, Cordeiro BF, da Silva SH, Oliveira ER, Lemos L, Cara DC, Faria AMC, Garric G (2020) Beneficial propionibacteria within a probiotic emmental cheese: impact on dextran sodium sulphate-induced colitis in mice. Microorganisms 8(3):380

    Article  CAS  PubMed Central  Google Scholar 

  • Rafter J (2004) The effects of probiotics on colon cancer development. Nutr Res Rev 17(2):277–284

    Article  PubMed  Google Scholar 

  • Rath HC, Ikeda JS, Linde HJ, Schölmerich J, Wilson KH, Sartor RB (1999) Varying cecal bacterial loads influences colitis and gastritis in HLA-B27 transgenic rats. Gastroenterology 116(2):310–319

    Article  CAS  PubMed  Google Scholar 

  • Reichmann F, Hassan AM, Farzi A, Jain P, Schuligoi R, Holzer P (2015) Dextran sulfate sodium-induced colitis alters stress-associated behaviour and neuropeptide gene expression in the amygdala-hippocampus network of mice. Sci Rep 5:9970

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ringel Y, Ringel-Kulka T, Maier D, Carroll I, Galanko JA, Leyer G, Palsson OS (2011) Clinical trial: probiotic bacteria Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 versus placebo for the symptoms of bloating in patients with functional bowel disorders-a double-blind study. J Clin Gastroenterol 45(6):518

    Article  PubMed  PubMed Central  Google Scholar 

  • Round JL, Mazmanian SK (2009) The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 9(5):313–323. https://doi.org/10.1038/nri2515

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rudolph U, Finegold MJ, Rich SS, Harriman GR, Srinivasan Y, Brabet P, Boulay G, Bradley A, Birnbaumer L (1995) Ulcerative colitis and adenocarcinoma of the colon in Gα i2-deficient mice. Nat Genet 10(2):143–150

    Article  CAS  PubMed  Google Scholar 

  • Sanchez-Munoz F, Dominguez-Lopez A, Yamamoto-Furusho JK (2008) Role of cytokines in inflammatory bowel disease. World J Gastroenterol 14(27):4280–4288. https://doi.org/10.3748/wjg.14.4280

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Santhanam S, Rajamanickam S, Motamarry A, Ramakrishna BS, Amirtharaj JG, Ramachandran A, Pulimood A, Venkatraman AJ (2012) Mitochondrial electron transport chain complex dysfunction in the colonic mucosa in ulcerative colitis. 18(11):2158–2168

    Google Scholar 

  • Schreiber S, Heinig T, Thiele H-G, Raedler AJG (1995) Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterology 108(5):1434–1444

    Google Scholar 

  • Seago N, Thompson J, Zhang X-J, Eloby-Childress S, Sadowska-Krowicka H, Rossi J, Currie M, Manning P, Clark D, Miller M (1970) Inducible nitric oxide synthase and guinea-pig ileitis induced by adjuvant. Mediators of Inflammation 4

    Google Scholar 

  • Sekirov I, Russell SL, Antunes LC, Finlay BB (2010) Gut microbiota in health and disease. Physiol Rev 90(3):859–904. https://doi.org/10.1152/physrev.00045.2009

    Article  CAS  PubMed  Google Scholar 

  • Selvig D, Piceno Y, Terdiman J, Zydek M, Umetsu SE, Balitzer D, Fadrosh D, Lynch K, Lamere B, Leith T (2020) Fecal microbiota transplantation in pouchitis: clinical, endoscopic, histologic, and microbiota results from a pilot study. Dig Dis Sci 65(4):1099–1106

    Article  CAS  PubMed  Google Scholar 

  • Sender R, Fuchs S, Milo RJ (2016) Revised estimates for the number of human and bacteria cells in the body. PLoS Biol 14(8):e1002533

    Google Scholar 

  • Shang Q, Sun W, Shan X, Jiang H, Cai C, Hao J, Li G, Yu G (2017) Carrageenan-induced colitis is associated with decreased population of anti-inflammatory bacterium, Akkermansia muciniphila, in the gut microbiota of C57BL/6J mice. Toxicol Lett 279:87–95

    Article  CAS  PubMed  Google Scholar 

  • Singh B, Read S, Asseman C, Malmström V, Mottet C, Stephens LA, Stepankova R, Tlaskalova H, Powrie F (2001) Control of intestinal inflammation by regulatory T cells. Immunol Rev 182:190–200. https://doi.org/10.1034/j.1600-065x.2001.1820115.x

    Article  CAS  PubMed  Google Scholar 

  • Steed H, Macfarlane GT, Blackett KL, Bahrami B, Reynolds N, Walsh SV, Cummings JH, Macfarlane S (2010) Clinical trial: the microbiological and immunological effects of synbiotic consumption–a randomized double-blind placebo-controlled study in active Crohn’s disease. Alimentary Pharmacol Therapeut 32(7):872–883

    Article  CAS  Google Scholar 

  • Steinhoff U, Brinkmann V, Klemm U, Aichele P, Seiler P, Brandt U, Bland PW, Prinz I, Zügel U, Kaufmann SH (1999) Autoimmune intestinal pathology induced by hsp60-specific CD8 T cells. Immunity 11(3):349–358

    Article  CAS  PubMed  Google Scholar 

  • Takeda K, Clausen BE, Kaisho T, Tsujimura T, Terada N, Förster I, Akira S (1999) Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10(1):39–49

    Article  CAS  PubMed  Google Scholar 

  • Targan SR, Hanauer SB, Van Deventer SJ, Mayer L, Present DH, Braakman T, DeWoody KL, Schaible TF, Rutgeerts PJ (1997) A short-term study of chimeric monoclonal antibody cA2 to tumor necrosis factor α for Crohn’s disease. New England J Med 337(15):1029–1036

    Article  CAS  Google Scholar 

  • Taylor AM, Thompson SV, Edwards CG, Musaad SM, Khan NA, Holscher HD (2019) Associations among diet, the gastrointestinal microbiota, and negative emotional states in adults. Nutr Neurosci:1–10

    Google Scholar 

  • Tlaskalova-Hogenova H, Stepankova R, Kozakova H, Hudcovic T, Vannucci L, Tuckova L, Rossmann P, Hrncir T, Kverka M, Zakostelska Z, Klimesova K, Pribylova J, Bartova J, Sanchez D, Fundova P, Borovska D, Srutkova D, Zidek Z, Schwarzer M, Drastich P, Funda DP (2011) The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases. Cell Mol Immunol 8(2):110–120. https://doi.org/10.1038/cmi.2010.67

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Uhlig HH, McKenzie BS, Hue S, Thompson C, Joyce-Shaikh B, Stepankova R, Robinson N, Buonocore S, Tlaskalova-Hogenova H, Cua DJJI (2006) Differential activity of IL-12 and IL-23 in mucosal and systemic innate immune pathology. Immunity 25(2):309–318

    Google Scholar 

  • Vaiserman AM, Koliada AK, Marotta F (2017) Gut microbiota: a player in aging and a target for anti-aging intervention. Ageing Res Rev 35:36–45. https://doi.org/10.1016/j.arr.2017.01.001

    Article  CAS  PubMed  Google Scholar 

  • Van Kruiningen HJ (2016) An infectious pig model of Crohn’s disease. Inflammat Bowel Dis 22(9):2106–2111

    Article  Google Scholar 

  • van Montfrans C, Pena MSR, Pronk I, Ten Kate FJ, te Velde AA, van Deventer SJ (2002) Prevention of colitis by interleukin 10–transduced T lymphocytes in the SCID mice transfer model. Gastroenterology 123(6):1865–1876

    Article  PubMed  Google Scholar 

  • Venturi A, Gionchetti P, Rizzello F, Peruzzo S, Zucconi E, Brigidi P, Matteuzzi K, Campieri M (1999) Impact on the faecal ora composition of a new probiotic preparation. Preliminary data on maintenance treatment of patients with ulcerative colitis intolerant or allergic to 5-aminosalicylic acid. Aliment Pharmacol Ther 13:1103–1108

    Google Scholar 

  • Vergin FV (1954) Anti-und probiotika. 25(4):116–119

    Google Scholar 

  • Walker JR, Ediger JP, Graff LA, Greenfeld JM, Clara I, Lix L, Rawsthorne P, Miller N, Rogala L, McPhail CM (2008) The Manitoba IBD cohort study: a population-based study of the prevalence of lifetime and 12-month anxiety and mood disorders. Am J Gastroenterol 103(8):1989–1997

    Article  PubMed  Google Scholar 

  • Wallace TC, Guarner F, Madsen K, Cabana MD, Gibson G, Hentges E, Sanders ME (2011) Human gut microbiota and its relationship to health and disease. Nutr Rev 69(7):392–403. https://doi.org/10.1111/j.1753-4887.2011.00402.x

    Article  PubMed  Google Scholar 

  • Wang L, Li C-L, Wang L, Yu W-B, Yin H-P, Zhang G-Y, Zhang L-F, Li S, Hu S-Y (2011) Influence of CXCR4/SDF-1 axis on E-cadherin/β-catenin complex expression in HT29 colon cancer cells. World J Gastroenterol 17(5):625

    Google Scholar 

  • Wang Y, Xie Q, Zhang Y, Ma W, Ning K, Xiang J-Y, Cui J, Xiang H (2020) Combination of probiotics with different functions alleviate DSS-induced colitis by regulating intestinal microbiota, IL-10, and barrier function. Appl Microbiol Biotechnol 104(1):335–349

    Article  CAS  PubMed  Google Scholar 

  • Watanabe M, Ueno Y, Yajima T, Okamoto S, Hayashi T, Yamazaki M, Iwao Y, Ishii H, Habu S, Uehira M (1998) Interleukin 7 transgenic mice develop chronic colitis with decreased interleukin 7 protein accumulation in the colonic mucosa. J Exp Med 187(3):389–402

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Watkins DI, Chen ZW, Hughes AL, Evans MG, Tedder TF, Letvin NL (1990) Evolution of the MHC class I genes of a New World primate from ancestral homologues of human non-classical genes. Nature 346(6279):60–63

    Article  CAS  PubMed  Google Scholar 

  • Watkins P, Warren B, Stephens S, Ward P, Foulkes R (1997) Treatment of ulcerative colitis in the cottontop tamarin using antibody to tumour necrosis factor alpha. Gut 40(5):628–633

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wen K, Li G, Bui T, Liu F, Li Y, Kocher J, Lin L, Yang X, Yuan L (2012) High dose and low dose Lactobacillus acidophilus exerted differential immune modulating effects on T cell immune responses induced by an oral human rotavirus vaccine in gnotobiotic pigs. Vaccine 30(6):1198–1207

    Article  CAS  PubMed  Google Scholar 

  • Xiao Y, Yan H, Diao H, Yu B, He J, Yu J, Zheng P, Mao X, Luo Y, Chen D (2017) Early gut microbiota intervention suppresses DSS-induced inflammatory responses by deactivating TLR/NLR signalling in pigs. Sci Rep 7(1):1–12

    Google Scholar 

  • Yeganeh PR, Leahy J, Spahis S, Patey N, Desjardins Y, Roy D, Delvin E, Garofalo C, Leduc-Gaudet J-P, St-Pierre DJ (2018) Apple peel polyphenols reduce mitochondrial dysfunction in mice with DSS-induced ulcerative colitis. J Nutr Biochem 57:56–66

    Google Scholar 

  • Yeung C, Chiau J, Cheng M, Chan W, Chang S, Jiang C, Lee H (2020) Immune modulation effects and safety of Lactobacillus casei variety rhamnosus in a chemotherapy-induced intestinal mucositis mouse model.

    Google Scholar 

  • Yun S-M, Kim S-H, Kim E-H (2019) The molecular mechanism of transforming growth factor-β signaling for intestinal fibrosis: a mini-review. Front Pharmacol 10:162

    Google Scholar 

  • Zaharuddin L, Mokhtar NM, Nawawi KNM, Ali RAR (2019) A randomized double-blind placebo-controlled trial of probiotics in post-surgical colorectal cancer. BMC Gastroenterol 19(1):131

    Article  PubMed  PubMed Central  Google Scholar 

  • Zaylaa M, Al Kassaa I, Alard J, Peucelle V, Boutillier D, Desramaut J, Dabboussi F, Pot B, Grangette C (2018) Probiotics in IBD: combining in vitro and in vivo models for selecting strains with both anti-inflammatory potential as well as a capacity to restore the gut epithelial barrier. J Funct Foods 47:304–315

    Article  CAS  Google Scholar 

  • Zeng L, Tan J, Xue M, Liu L, Wang M, Liang L, Deng J, Chen W, Chen Y (2020) An engineering probiotic producing defensin-5 ameliorating dextran sodium sulfate-induced mice colitis via Inhibiting NF-kB pathway. J Transl Med 18(1):1–15

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, Uttar Pradesh, India

    Priyanka Devi

  2. Texas Tech University Health Sciences Center, Ophthalmology Department Lubbock General, Lubbock, TX, USA

    Yerramsetti Nanaji

  3. University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India

    Nikita Khanna, Ashok Kumar Yadav & Sandip V. Pawar

Authors
  1. Priyanka Devi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yerramsetti Nanaji
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Nikita Khanna
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ashok Kumar Yadav
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Sandip V. Pawar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sandip V. Pawar .

Editor information

Editors and Affiliations

  1. University Institute of Pharmaceutical Sciences, Chandigarh, Punjab, India

    Sandip V. Pawar

  2. Department of Microbiology, Panjab University, Chandigarh, Punjab, India

    Praveen Rishi

Rights and permissions

Reprints and permissions

Copyright information

© 2021 The Author(s), under exclusive licence to Springer Nature Singapore Pte Ltd.

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Devi, P., Nanaji, Y., Khanna, N., Yadav, A.K., Pawar, S.V. (2021). Animal Models for Probiotic Interventions Under Gut Inflammatory Conditions. In: Pawar, S.V., Rishi, P. (eds) Probiotic Research in Therapeutics. Springer, Singapore. https://doi.org/10.1007/978-981-33-6236-9_4

Download citation

Publish with us

Policies and ethics

Search

Navigation