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Progress in Diagnosis and Treatment of Sudden Death Caused by Respiratory Diseases

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Sudden Death

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Abstract

Sudden death (SD) is the most serious condition in humans. The World Health Organization defined it as follows: “In an unexpectedly short period of time, a sudden death as a result of a natural illness is a sudden death in a patient who is usually in good health or appears to be in good health.” Sudden death is mainly caused by cardiovascular diseases; because of the sudden onset, most of them occur outside the hospital. Respiratory diseases that cause sudden death occur from time to time. Common diseases include acute pulmonary embolism, asthma, acute respiratory distress syndrome (ARDS), etc. These diseases have the characteristics of rapid progress and rapid death, which pose a serious threat to human health. This chapter mainly describes the analysis of the sudden death caused by respiratory diseases and studies the latest progress in diagnosis and treatment. Early identification and treatment are of great significance to reduce mortality and thus save lives.

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References

  1. Becker AB, Abrams EM. Asthma guidelines: the global initiative for asthma in relation to national guidelines. Curr Opin Allerg Clin Immunol. 2017;17(2):99.

    Article  Google Scholar 

  2. Collaborators G B D M M. Global, regional, and national levels of maternal mortality, 1990-2015: a systematic analysis for the global burden of disease study 2015. Lancet. 2016;388(10053):1775–812.

    Article  Google Scholar 

  3. Huang K, Yang T, Xu J, et al. Prevalence, risk factors, and management of asthma in China: a national cross-sectional study. Lancet. 2019;394(10196):407–18.

    Article  PubMed  Google Scholar 

  4. Marco RD, Locatelli F, Cazzoletti L, et al. Incidence of asthma and mortality in a cohort of young adults: a 7-year prospective study. Respiratory Res. 2005;6(1):95.

    Article  Google Scholar 

  5. Gullach AJ, Risgaard B, Lynge TH, et al. Sudden death in young persons with uncontrolled asthma—a nationwide cohort study in Denmark. BMC Pulm Med. 2015;15:35.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Xu Z. Respiratory diseases and sudden death. Chinese Emerg Med. 1994;01:47–50.

    Google Scholar 

  7. Shen Z. 19 clinical analysis of sudden death caused by bronchial asthma. Chinese J Modern Med. 2007;17(14):1780.

    Google Scholar 

  8. Chuntao L, Yulin F. Fatal asthma and its special types. Med J New Knowled. (1):4–5.

    Google Scholar 

  9. Tieying Z. Effect of irregular use of β 2 receptor agonists on acute attack of bronchial asthma. Chinese Ethnic Folk Med. 2010;19(4):31.

    Google Scholar 

  10. Reddel HK, Taylor DR, Bateman ED, et al. An official American thoracic society/European respiratory society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice. Am J Respir Crit Care Med. 2009;180(1):59–99.

    Article  PubMed  Google Scholar 

  11. Menzella F, Lusuardi M, Galeone C, et al. Profile of anti-IL-5 mAb mepolizumab in the treatment of severe refractory asthma and hypereosinophilic diseases. J Asthma Allergy. 2015;8:105–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Hantera M, El-Hafiz HA, Abdelnaby AY, et al. Serum levels of angiopoietin-2 and vascular endothelial growth factor in severe refractory asthma. Egypt J Chest Dis Tuberc. 2014;63(4):751–4.

    Article  Google Scholar 

  13. Susumu N, Ho LH, Mang Y, et al. Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice. J Allergy Clin Immunol. 2007;120(1):48–55.

    Article  Google Scholar 

  14. Brannan JD, Lougheed MD. Airway hyperresponsiveness in asthma: mechanisms, clinical significance, and treatment. Front Physiol. 2012;3:460.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Jatakanon A, Uasuf C, Maziak W, et al. Neutrophilic inflammation in severe persistent asthma. Am J Respir Crit Care Med. 1999;160(5 Pt 1):1532–9.

    Article  CAS  PubMed  Google Scholar 

  16. Jeffery PK. Proceedings of the American Thoracic Society. Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2004;1(3):176–83.

    Article  CAS  PubMed  Google Scholar 

  17. Lai HY, Rogers DF. New pharmacotherapy for airway mucus hypersecretion in asthma and COPD: targeting intracellular signaling pathways. J Aerosol Med Pulm Drug Deliv. 2010;23(4):219–31.

    Article  CAS  PubMed  Google Scholar 

  18. Fahy JV. Goblet cell and mucin gene abnormalities in asthma*. Chest. 2002;122(6):320S–6S.

    Article  CAS  PubMed  Google Scholar 

  19. Scott KM, Lim C, Al-Hamzawi A, et al. Association of mental disorders with subsequent chronic physical conditions: world mental health surveys from 17 countries. JAMA Psychiat. 2016;73(2):150–8.

    Article  Google Scholar 

  20. Haining L, Ma Q, Wang C, et al. Multivariate analysis of anxiety/depression in patients with bronchial asthma. Int Resp Magazine. 2017;37(23):1761–5.

    Google Scholar 

  21. Strine T, Mokdad A, Balluz L, et al. Impact of depression and anxiety on quality of life, health behaviors, and asthma control among adults in the United States with asthma, 2006. J Asthma. 2008;45(2):123–33.

    Article  PubMed  Google Scholar 

  22. Kolbe JJT. Case-control study of severe life threatening asthma (SLTA) in adults: psychological factors. Thorax. 2002;57(4):317–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Yihu Z, Li Z, Jun H, et al. Toxicity of aminophylline: a cause of death of medical negligence that has not been paid attention to. Evidence Sci. 2000;7(2):64–5.

    Google Scholar 

  24. Juan. Combination of epinephrine and aminophylline in the treatment of fatal asthma. Chinese Gerontol. 2014;(16):4678–4679.

    Google Scholar 

  25. Thottathil P, Acharya J, Moss AJ, et al. Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists. Am J Cardiol. 2008;102(7):871–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Ekström M, Nwaru BI, Hasvold P, et al. Oral corticosteroid use, morbidity, and mortality in asthma: a nationwide prospective cohort study in Sweden. Allergy. 2019;74(11):2181–90.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Bozkurt Yilmaz HE, Yilmaz M, Şen N, et al. Assessment of atrial fibrillation and ventricular arrhythmia risk in patients with asthma by P wave/corrected QT interval dispersion. Eur Rev Med Pharmacol Sci. 2018;22(3):756.

    CAS  PubMed  Google Scholar 

  28. Herlitz J, Ekström L, Wennerblom B, et al. Hospital mortality after out-of-hospital cardiac arrest among patients found in ventricular fibrillation. Resuscitation. 1995;29(1):11–21.

    Article  CAS  PubMed  Google Scholar 

  29. Wang H, Yonghong Z, Mingxia L. Advances in the pathogenesis of hypoxic pulmonary hypertension. Chinese J Pract Pediatr. 2009;03:74–7.

    Google Scholar 

  30. Xiaohong J, Jinbo Z, Jianhua C, et al. Clinical study on the relationship between obesity and the severity and prognosis of severe asthma. Modern Pract Med. 2013;025(004):385–6.

    Google Scholar 

  31. Cluley S, Cochrane GM. Psychological disorder in asthma is associated with poor control and poor adherence to inhaled steroids. Respir Med. 2001;95(1):37–9.

    Article  CAS  PubMed  Google Scholar 

  32. Steyn E, Mohamed Z, Husselman C. Non-invasive vagus nerve stimulation for the treatment of acute asthma exacerbations—results from an initial case series. Int J Emerg Med. 2013;6(1):7.

    Article  PubMed  PubMed Central  Google Scholar 

  33. Suteng S, Wan X. Current situation and countermeasures of fatal asthma. Japan Med Introd. 1999;1:7–9.

    Google Scholar 

  34. Johnson AJ, Nunn AJ, Somner AR, et al. Circumstances of death from asthma. Br Med J. 1984;288:1870–2.

    Article  CAS  Google Scholar 

  35. Hannaway PJ. Demographic characteristics of patients experiencing near-fatal and fatal asthma: results of a regional survey of 400 asthma specialists. Ann Allergy Asthma Immunol. 2000;84(6):587–93.

    Article  CAS  PubMed  Google Scholar 

  36. Investigation and analysis of disease severity and complications of patients with bronchial asthma in urban outpatient clinics in China. Chinese J Respir Crit Care. 2019;18(01):57, 59–62.

    Google Scholar 

  37. Huang-Yang HE, Hui C. Efficacy of BiPAP respiratory therapy in patients with exacerbations of acute severe bronchial asthma. J Trop Med. 2009;9(11):1278–9.

    Google Scholar 

  38. Liang D. Application value of non-invasive mechanical ventilation in emergency rescue of patients with severe asthma complicated with type II respiratory failure. Chinese Dis Med. 2015;000(010):118–119,120.

    Google Scholar 

  39. Asthma Group, Respiratory Association of Chinese Medical Association, China Asthma Alliance. Evaluation and management of acute attack of bronchial asthma by Chinese experts. Clin Med Res Pract. 2018;3(06):207.

    Google Scholar 

  40. Rowe BH, Bretzlaff JA, Bourdon C, et al. Magnesium sulfate for treating exacerbations of acute asthma in the emergency department. Cochrane Database Syst Rev. 2000;(2):CD001490.

    Google Scholar 

  41. Jinguo X, Jinsong J, Zaiqing L. Application of fiberoptic bronchoscope in the rescue of patients with critical asthma. Med Clin Res. 2007;24(3):463–5.

    Google Scholar 

  42. Corren J, Parnes JR, Wang L, et al. Tezepelumab in adults with uncontrolled asthma. N Engl J Med. 2017;377(10):936–46.

    Article  CAS  PubMed  Google Scholar 

  43. Pham TH, Damera G, Newbold P, et al. Reductions in eosinophil biomarkers by benralizumab in patients with asthma. Respir Med. 2016;111(21):9.

    Google Scholar 

  44. Ferguson GT, Fitzgerald JM, Bleecker ER, et al. Benralizumab for patients with mild to moderate, persistent asthma (BISE): a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Respir Med. 2017;5(7):568–76.

    Article  CAS  PubMed  Google Scholar 

  45. Milenkovi BA, Stankovi IJ, Ili AM, et al. Peak expiratory flow-guided self-management treatment of asthma in Serbia. J Asthma. 2007;44(9):699–704.

    Article  Google Scholar 

  46. Kimura H, Konno S, Makita H, et al. Prospective predictors of exacerbation status in severe asthma over a 3-year follow-up. Clin Exp Allergy. 2018;48(9):1137–46.

    Article  CAS  PubMed  Google Scholar 

  47. Wiener RS, Schwartz LM, Woloshin S. Time trends in pulmonary embolism in the United States: evidence of over diagnosis. Arch Intern Med. 2011;171(9):831–7.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Konstantinides SV. Trends in incidence versus case fatality rates of pulmonary embolism: good news or bad news? Thromb Haemost. 2016;115(2):233–5.

    Article  PubMed  Google Scholar 

  49. Cohen AT, Agnelli G, Anderson FA, et al. Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbidity and mortality. Thromb Haemost. 2007;98(4):756–64.

    CAS  PubMed  Google Scholar 

  50. Investigators P. Value of the ventilation/perfusion scan in acute pulmonary embolism. Results of the prospective investigation of pulmonary embolism diagnosis (PIOPED). JAMA. 1990;263(20):2753–9.

    Article  Google Scholar 

  51. Stein PD, Beemath A, Matta F, et al. Clinical characteristics of patients with acute pulmonary embolism: data from PIOPED II. Am J Med. 2007;120(10):871–9.

    Article  PubMed  PubMed Central  Google Scholar 

  52. Kucher N, Goldhaber SZ. Management of massive pulmonary embolism. Circulation. 2005;112(2):e28–32.

    Article  PubMed  Google Scholar 

  53. Rodger MA, Carrier M, Jones GN, et al. Diagnostic value of arterial blood gas measurement in suspected pulmonary embolism. Am J Respir Crit Care Med. 2000;162(6):2105–8.

    Article  CAS  PubMed  Google Scholar 

  54. Geibel A, Zehender M, Kasper W, et al. Prognostic value of the ECG on admission in patients with acute major pulmonary embolism. Eur Respir J. 2005;25(5):843–8.

    Article  CAS  PubMed  Google Scholar 

  55. Remy-Jardin M, Pistolesi M, Goodman LR, et al. Management of suspected acute pulmonary embolism in the era of CT angiography: a statement from the Fleischner Society. Radiology. 2007;245(2):315–29.

    Article  PubMed  Google Scholar 

  56. Raja AS, Greenberg JO, Qaseem A, et al. Evaluation of patients with suspected acute pulmonary embolism: best practice advice from the clinical guidelines committee of the American college of physicians. Ann Intern Med. 2015;163(9):701–11.

    Article  PubMed  Google Scholar 

  57. Courtney DM, Miller C, Smithline H, et al. Prospective multicenter assessment of interobserver agreement for radiologist interpretation of multidetector computerized tomographic angiography for pulmonary embolism. J Thromb Haemost. 2010;8(3):533–9.

    Article  CAS  PubMed  Google Scholar 

  58. Wang L, Kang W, Zu M, et al. Application of 128-slice spiral CT combination scanning in the diagnosis of embolisms in pulmonary arteries and lower extremity veins. Exp Ther Med. 2014;7(2):401–4.

    Article  PubMed  Google Scholar 

  59. Kligerman SJ, Lahiji K, Galvin JR, et al. Missed pulmonary emboli on CT angiography: assessment with pulmonary embolism-computer-aided detection. AJR Am J Roentgenol. 2014;202(1):65–73.

    Article  PubMed  Google Scholar 

  60. Musset D, Parent F, Meyer G, et al. Diagnostic strategy for patients with suspected pulmonary embolism: a prospective multicentre outcome study. Lancet. 2002;360(9349):1914–20.

    Article  PubMed  Google Scholar 

  61. Kruip MJ, Leclercq MG, Van Der Heul C, et al. Diagnostic strategies for excluding pulmonary embolism in clinical outcome studies. A systematic review. Ann Intern Med. 2003;138(12):941–51.

    Article  PubMed  Google Scholar 

  62. Yoo HH, Nunes-Nogueira VS, Fortes Villas Boas PJ, et al. Outpatient versus inpatient treatment for acute pulmonary embolism . Cochrane Database Syst Rev. 2019;(3):CD010019.

    Google Scholar 

  63. Roy PM, Corsi DJ, Carrier M, et al. Net clinical benefit of hospitalization versus outpatient management of patients with acute pulmonary embolism. J Thromb Haemost. 2017;15(4):685–94.

    Article  PubMed  Google Scholar 

  64. Konstantinides SV, Torbicki A, Agnelli G, et al. ESC guidelines on the diagnosis and management of acute pulmonary embolism. Eur Heart J. 2014;35(43):3033–69, 69a-69k

    Article  CAS  PubMed  Google Scholar 

  65. Kearon C, Akl EA, Comerota AJ, et al. Antithrombotic therapy for VTE disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American college of chest physicians evidence-based clinical practice guidelines. Chest. 2012;141(2 Suppl):e419S–e96S.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Yoo H H, Queluz TH, El Dib R. Anticoagulant treatment for subsegmental pulmonary embolism. Cochrane Database Syst Rev. 2016;(1):CD010222.

    Google Scholar 

  67. Chechi T, Vecchio S, Spaziani G, et al. Rheolytic thrombectomy in patients with massive and submassive acute pulmonary embolism. Catheter Cardiovasc Interv. 2009;73(4):506–13.

    Article  PubMed  Google Scholar 

  68. Nassiri N, Jain A, Mcphee D, et al. Massive and submassive pulmonary embolism: experience with an algorithm for catheter-directed mechanical thrombectomy. Ann Vasc Surg. 2012;26(1):18–24.

    Article  PubMed  Google Scholar 

  69. Stein PD, Goodman LR, Hull RD, et al. Diagnosis and management of isolated subsegmental pulmonary embolism: review and assessment of the options. Clin Appl Thromb Hemost. 2012;18(1):20–6.

    Article  PubMed  Google Scholar 

  70. Osborne ZJ, Rossi P, Aucar J, et al. Surgical pulmonary embolectomy in a community hospital. Am J Surg. 2014;207(3):337–41. discussion 40-1

    Article  PubMed  Google Scholar 

  71. Lee T, Itagaki S, Chiang YP, et al. Survival and recurrence after acute pulmonary embolism treated with pulmonary embolectomy or thrombolysis in New York State, 1999 to 2013. J Thorac Cardiovasc Surg. 2018;155(3):1084–90.e12.

    Article  PubMed  Google Scholar 

  72. Meneveau N, Seronde MF, Blonde MC, et al. Management of unsuccessful thrombolysis in acute massive pulmonary embolism. Chest. 2006;129(4):1043–50.

    Article  PubMed  Google Scholar 

  73. Neely RC, Byrne JG, Gosev I, et al. Surgical embolectomy for acute massive and submassive pulmonary embolism in a series of 115 patients. Ann Thorac Surg. 2015;100(4):1245–51. discussion 51-2

    Article  PubMed  Google Scholar 

  74. Rosenberger P, Shernan SK, Mihaljevic T, et al. Transesophageal echocardiography for detecting extrapulmonary thrombi during pulmonary embolectomy. Ann Thorac Surg. 2004;78(3):862–6. discussion 6

    Article  PubMed  Google Scholar 

  75. Becattini C, Casazza F, Forgione C, et al. Acute pulmonary embolism: external validation of an integrated risk stratification model. Chest. 2013;144(5):1539–45.

    Article  PubMed  Google Scholar 

  76. Ten Wolde M, Sohne M, Quak E, et al. Prognostic value of echocardiographically assessed right ventricular dysfunction in patients with pulmonary embolism. Arch Intern Med. 2004;164(15):1685–9.

    Article  PubMed  Google Scholar 

  77. Beenen LFM, Bossuyt PMM, Stoker J, et al. Prognostic value of cardiovascular parameters in computed tomography pulmonary angiography in patients with acute pulmonary embolism. Eur Respir J. 2018;52(1):1702611.

    Article  PubMed  Google Scholar 

  78. Casazza F, Bongarzoni A, Centonze F, et al. Prevalence and prognostic significance of right-sided cardiac mobile thrombi in acute massive pulmonary embolism. Am J Cardiol. 1997;79(10):1433–5.

    Article  CAS  PubMed  Google Scholar 

  79. Torbicki A, Galie N, Covezzoli A, et al. Right heart thrombi in pulmonary embolism: results from the International Cooperative Pulmonary Embolism Registry. J Am Coll Cardiol. 2003;41(12):2245–51.

    Article  PubMed  Google Scholar 

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  1. Department of Pulmonary & Critical Care Medicine, General Hospital of Chinese People’s Liberation Army, Beijing, People’s Republic of China

    Junfeng Chen, Yi Xu, Jiang Wang & Guo Xin Mo

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  1. Junfeng Chen
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  2. Yi Xu
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  1. Emergency Department, The First Medical Center of Chinese PLA General Hospital, Beijing, China

    Haiyan Zhu

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Chen, J., Xu, Y., Wang, J., Mo, G.X. (2021). Progress in Diagnosis and Treatment of Sudden Death Caused by Respiratory Diseases. In: Zhu, H. (eds) Sudden Death. Springer, Singapore. https://doi.org/10.1007/978-981-15-7002-5_19

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  • DOI: https://doi.org/10.1007/978-981-15-7002-5_19

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