Abstract
Multiple myeloma (MM) is a rarely seen hematological malignancy, which has been characterized by the malignant proliferation of monoclonal plasma cells. MM generates uncontrolled growth of monoclonal plasma cells in the bone marrow, leading to production of nonfunctional intact immunoglobulin or immunoglobulin chain. MM is associated with the addition of chromosome abnormalities, copy number abnormalities, genetic mutation, and gene expression signature. MM is incurable but highly treatable by several targeted drug therapy, these drug show synergistic beneficial effect with phytochemicals. Phytochemicals are natural compound inbuilt with anti –inflammatory and anti-cancer properties. Specific plants and there phytochemicals were investigated and processed for their anti – inflammatory and anti-cancerous properties. Phytochemicals has antioxidant and anti-inflammatory activity had found to be beneficial in suppression of abnormal plasma cell growth. The aim of this review is to examine the synergistic pathways between phytochemicals and anti- cancer drug used in the treatment of multiple myeloma.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Adams J. The proteasome: a suitable anti neoplastic target. Nat Rev Cancer. 2004;4:349–60.
Aggarwal BB, Kumar A, Aggarwal MS, et al. Curcumin derived from turmeric Curcuma longa: a spice for all seasons. In: Phytopharmaceuticals in cancer chemoprevention. Boca Raton: CRC Press; 2005. p. 349–87.
Amantini C, Ballarini P, Caprodossi S, et al. Triggering of transient receptor potential type 1 (TRPV1) by capsaicin induces FAS/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner. Carcinogenesis. 2009;30:1320–9.
Anupama N, Madhumitha G, Rajesh KS. Role of dried fruits of Carissa carandas as anti-inflammatory agents and the analysis of phytochemical constituents by GC-MS. BioMed Res Int. 2014;2014:6.
Bley KB, Boorman G, Mohammad B, et al. Comprehensive review of the carcinogenic and anticarcinogenic potential of capsaicin. Toxicol Pathol. 2012;40:847–73.
Choi EJ, Kim T, Lee MS. Pro-apoptotic effect and cytotoxicity of genistein and genistin in human ovarian cancer sk-ov-3 cells. Life Sci. 2007;80(15):1403–8.
Chung CS, Jiang Y, Cheng D, et al. Impact of adenomatous polyposis coli (APC) tumor suppressor gene in human colon cancer cell lines on cell cycle arrest by apigenin. Mol Carcinog. 2007;46(9):773–82.
Cragg GM, Newman DJ. Plants as a source of anticancer agents. J Ethnopharmacol. 2005;100:72–9.
Debes-Marun CS, Dewald GW, Bryant S, et al. Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma. Leukemia. 2003;17:427–36.
Dijsselbloem N, Vanden BW, De Naeyer A, et al. Soy isoflavonephyto-pharmaceuticals in interleukin-6 affections. Multi-purpose nutraceuticals at the crossroad of hormone replacement, anti-cancer and anti-inflammatory therapy. Biochem Pharmacol. 2004;68(6):1171–85.
El-Alfy TS, Ezzat SM, Hegazy AK, et al. Isolation of biologically active constituents from Moringaperegrina (Forssk.) Fiori. (family: Moringaceae) growing in Egypt. Pharmacogn Mag. 2011;7(26):109–15.
Harrison AM, Thalji NM, Greenberg AJ, et al. Rituximab for non-Hodgkin’s lymphoma: a story of rapid success in translation. Clin Transl Sci. 2014;1:82–6.
Haywood, Good P, Khan S, et al. Corticosteroids for the management of cancer-related pain in adults. Cochrane Database Syst Rev. 2015;4:CD010756.
Ito K, Nakazato T, Yamato K, et al. Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species. Cancer Res. 2004;64:1071–8.
Kyle RA, Therneau TM, Rajkumar SV, et al. Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med. 2006;354:1362–9.
Landgren O, Kyle RA, Pfeifer RM, et al. Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood. 2009;113:5412–7.
Langcake P, Pryce RJ. Production of resveratrol by vitis-vinifera and other members of vitaceae as a response to infection or injury. Physiol Plant Pathol. 1976;9:77–86.
Li Z, Yang Z, Peng X, et al. Nuclear factor-κB is involved in the protocadherin-10-mediated pro-apoptotic effect in multiple myeloma. Mol Med Rep. 2014;10:832–8.
Mahlberg Paul G, Soo Kim E. THC (tetrahyrdocannabinol) accumulation in glands of Cannabis (Cannabaceae). Hemp Rep. 2001;3:17.
Manu KA, Kuttan G. Ursolic acid induces apoptosis by activating p53 and caspase-3 gene expressions and suppressing NF-B mediated activation of bcl-2 in B16F-10melanoma cells. Int Immunopharmacol. 2008;8:974–81.
Seidl S, Kaufmann H, Drach J. New insights into the pathophysiology of multiple myeloma. Lancet Oncol. 2003;4:557–64.
Swerdlow SH, Campo E, Harris NL, et al. WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon: IARC Press; 2008.
Vargo MA, Voss OH, Poustka F. Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. Biochem Pharmacol. 2006;72:681–92.
Wang IK, Lin-Shiau SY, Lin JK. Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells. Eur J Cancer. 1999;35:1517–25.
Watt JM, Breyer BW, Gerdina M. The medicinal and poisonous plants of Southern and Eastern Africa. 2nd ed. Edinburgh: Oxford University Press; 1962.. Pub. E & S Livingstone
Wick W, Grimmel C, Wagenknecht B. Betulinic acid-induced apoptosis in glioma cells: a sequential requirement for new protein synthesis, formation of reactive oxygen species, and caspase processing. J Pharmacol Exp Ther. 1999;289:1306–12.
Yang CS, Landau JM, Huang MT, et al. Inhibition of carcinogenesis by dietary polyphenolic compounds. Annu Rev Nutr. 2001;21:381–406.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Singapore Pte Ltd.
About this chapter
Cite this chapter
Singh, S., Dwivedi, A. (2019). Recent Advances in Phytochemicals and Their Synergistic Role in Multiple Myeloma. In: Kumar, S., Egbuna, C. (eds) Phytochemistry: An in-silico and in-vitro Update. Springer, Singapore. https://doi.org/10.1007/978-981-13-6920-9_5
Download citation
DOI: https://doi.org/10.1007/978-981-13-6920-9_5
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-13-6919-3
Online ISBN: 978-981-13-6920-9
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)