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Adenocarcinoma and Its Precursor of the Uterine Cervix: Current Concept

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Pathology of Female Cancers

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Abstract

Cervical adenocarcinoma accounts for up to 25% of all cervical carcinomas. Adenocarcinoma in situ (AIS) is a widely recognized precursor of adenocarcinoma. While most cervical adenocarcinomas are associated with high-risk human papillomavirus (HPV), the minority are HPV-negative. The most common cervical adenocarcinoma is endocervical adenocarcinoma, usual type, which is characterized by mucin-poor neoplastic cells. Classification of mucinous carcinoma has markedly changed. Gastric-type mucinous carcinoma is a recently recognized subtype that includes minimal deviation adenocarcinoma as the extremely well-differentiated end of this category. It is HPV-negative and clinically aggressive. Endometrioid carcinoma is a poorly defined subtype, and differential diagnosis from endocervical adenocarcinoma, usual type, is subjective. Endometrioid carcinoma is considered to be rare, and its incidence is estimated to be less than 5%. In recent years, most cases of clear cell carcinoma have not been associated with diethylstilbestrol (DES) exposure. Serous carcinoma of the cervix is extremely rare, and metastatic carcinoma should be excluded before its diagnosis. Mesonephric carcinoma is not associated with high-risk HPV.

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  1. Division of Diagnostic Pathology, Shiga University of Medical Science, Ohtsu, Shiga, Japan

    Suzuko Moritani

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  1. Department of Pathology, Kawasaki Medical School, Kurashiki, Japan

    Takuya Moriya

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Moritani, S. (2018). Adenocarcinoma and Its Precursor of the Uterine Cervix: Current Concept. In: Moriya, T. (eds) Pathology of Female Cancers. Springer, Singapore. https://doi.org/10.1007/978-981-10-8606-9_2

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