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Luminescent Polymeric Nanovectors Loaded with Darunavir for Treatment of HIV-Associated Neurological Diseases

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Toxic Chemical and Biological Agents

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Abstract

This study presents the use of biodegradable poly (D,L-lactide-co-glycolide) (PLGA)-based NPs as nanovectors for the delivery of biocompatible luminescent Carbon Dots (C-Dots) and the antiretroviral drug Danuvir (DRV).

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References

  1. Latronico T et al (2018) In vitro effect of antiretroviral drugs on cultured primary astrocytes: analysis of neurotoxicity and matrix metalloproteinase inhibition. J Neurochem 144(3):271–284

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  2. Panniello A et al (2018) Luminescent oil-soluble carbon dots toward white light emission: a spectroscopic study. J Phys Chem C 122(1):839–849

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  3. Liuzzi GM et al (2004) Anti-HIV drugs decrease the expression of matrix metalloproteinases in astrocytes and microglia. Brain 127(2):398–407

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Author information

Authors and Affiliations

  1. Istituto per i Processi Chimico-Fisici-CNR SS Bari, Bari, Italy

    F. Rizzi, A. Panniello, N. Denora, E. Fanizza, M. Striccoli, A. Agostiano, M. L. Curri & N. Depalo

  2. Dipartimento di Bioscienze, Biotecnologie e Biofarmaceutica, Università degli Studi di Bari Aldo Moro, Bari, Italy

    T. Latronico, I. Arduino, A. Fasano & G. M. Liuzzi

  3. Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Bari, Italy

    V. Laquintana

  4. Università degli Studi di Bari Aldo Moro, Dipartimento di Farmacia, Scienze del Farmaco,, Bari, Italy

    N. Denora

  5. Dipartimento di Sanità Pubblica e Malattie Infettive, Università degli Studi di Roma “Sapienza”, Rome, Italy

    C. M. Mastroianni

  6. Dipartimento di Chimica, Università degli studi di Bari ‘Aldo Moro’, Bari, Italy

    E. Fanizza, A. Agostiano & M. L. Curri

Authors
  1. F. Rizzi
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  2. T. Latronico
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  3. A. Panniello
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  4. V. Laquintana
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  5. N. Denora
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  6. I. Arduino
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  7. A. Fasano
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  8. C. M. Mastroianni
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  9. E. Fanizza
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  10. M. Striccoli
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  11. A. Agostiano
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  12. G. M. Liuzzi
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  13. M. L. Curri
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  14. N. Depalo
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Corresponding author

Correspondence to F. Rizzi .

Editor information

Editors and Affiliations

  1. Department of Chemistry and Chemical Technology, University of Calabria, Arcavacata di Rende, Italy

    Giovanni Sindona

  2. Special Projects Science Branch, Fisheries and Oceans Canada, St. John’s, NL, Canada

    Joseph H. Banoub

  3. Department of Pharmacy, Health and Nurture Science, University of Calabria, Rende, Italy

    Maria Luisa Di Gioia

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Rizzi, F. et al. (2020). Luminescent Polymeric Nanovectors Loaded with Darunavir for Treatment of HIV-Associated Neurological Diseases. In: Sindona, G., Banoub, J.H., Di Gioia, M.L. (eds) Toxic Chemical and Biological Agents. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-024-2041-8_25

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