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RNA Tumour Viruses: Interesting Interactions with the Host Genome

  • Chapter
Genetic Origins of Tumor Cells

Part of the book series: Developments in Oncology ((DION,volume 1))

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Abstract

Horizontally transmitted RNA tumour viruses establish after infection a somatic DNA provirus into cellular DNA. Transcription of the provirus which is under host control usually leads to the synthesis of a 35S RNA molecule, which may: (a) be incorporated in a dimeric form into new virions; (b) serve as messenger for the precursor proteins of the viral core polypeptides and occasionally also for the RNA-dependent DNA polymerase; or (c) be processed into smaller sized messengers for the precursor protein of the viral envelope glycoprotein and of the gene, associated with oncogenic transformation, whose product in a few systems has been described. Host genes may interfere with these processes, often leading to the arrest of neoplastic conversion.

RNA tumour viruses may also be transmitted as genetic factors of the host. Expression of germinal proviruses can be regulated at either the transcriptional or translational level. Mutations in controlling genes or treatment with carcinogens may lead to the release of virus. Highly oncogenic viruses may result of the recombination between different types of such genetically transmitted endogenous viruses.

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  1. P. Bentvelzen
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  1. The Netherlands Cancer Institute, Amsterdam, The Netherlands

    F. J. Cleton M.D.

  2. Laboratory for Radiation Genetics and Chemical Mutagenesis, Leiden, The Netherlands

    J. W. I. M. Simons Ph.D.

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© 1980 Martinus Nijhoff Publishers bv, The Hague/Boston/London

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Bentvelzen, P. (1980). RNA Tumour Viruses: Interesting Interactions with the Host Genome. In: Cleton, F.J., Simons, J.W.I.M. (eds) Genetic Origins of Tumor Cells. Developments in Oncology, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-009-8823-1_4

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