Abstract
Reconstruction using liquid nitrogen-treated tumor-bearing bone has been utilized clinically since 1999 after its safety was confirmed by basic research. It provides several advantages: simplicity, osteoinduction, osteoconduction, short treatment time, optimal fit, sufficient biochemical strength, contagion-free, easy attachment of tendons and ligaments, and cryoimmunological activity. Time-dependent histological revitalization is also observed in frozen bone. There are two methods using liquid nitrogen-treated autografts: the pedicle freezing method and the free freezing method. The pedicle freezing method involves the dislocation of the joint proximal to the tumor or the use of osteotomy. The distal portion maintains continuity with the body in a pedicle form, and the affected bone is inverted and liquid nitrogen treatment is performed. The free freezing method involves resection and temporary removal of the affected bone and its treatment with liquid nitrogen. Satisfactory union can be achieved using liquid nitrogen-treated bone, and good clinical outcomes have been obtained in the midterm and long term without any case of recurrence from the treated bone. Reconstruction using liquid nitrogen-treated bone is a useful reconstruction method after resection of osteosarcoma.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Friedman MA, Carter SK. The therapy of osteogenic sarcoma- current status and thoughts for the future. J Surg Oncol. 1972;4:482–510.
Tsuchiya H, Tomita K, Mori Y, et al. Marginal excision for osteosarcoma with caffeine assisted chemotherapy. Clin Orthop Relat Res. 1999;358:27–35.
Kanazawa Y, Tsuchiya H, Nonomura A, et al. Intentional marginal excision of osteosarcoma of the proximal fibula to preserve limb function. J Orthop Sci. 2003;8:757–61.
Yamamoto N. Experimental study for reconstruction using liquid nitrogen treated tumor bearing bone. Juzen Gakkaishi. 2000;109:193–202.
Yamamoto N, Tsuchiya H, Tomita K. Effects of liquid nitrogen treatment on the proliferation of osteosarcoma and the biomechanical properties of normal bone. J Orthop Sci. 2003;8:374–80.
Tsuchiya H, Wan SL, Sakayama K, et al. Reconstruction using an autograft containing tumour treated by liquid nitrogen. J Bone Joint Surg (Br). 2005;87:218–25.
Sakayama K, Tsuchiya H, Fujibuchi T, Kidani T, Tanji N, Yamamoto H. Pathological findings of an autograft containing osteosarcoma treated by liquid nitrogen retrieved 2 years after implantation. J Orthop Sci. 2006;11:655–6.
Tanzawa Y, Tsuchiya H, Shirai T, Hayashi K, Yo Z, Tomita K. Histological examination of frozen autograft treated by liquid nitrogen removed after implantation. J Orthop Sci. 2009;14:761–8.
Yamamoto N, Inatani H, Shirai T, et al. Histological study on liquid nitrogen-treated tumor-bearing bone of the proximal femur excised eight years after transplantation. Low Temp Med. 2012;38:5–8.
Tsuchiya H, Nishida H, Srisawat P, et al. Pedicle frozen autograft reconstruction in malignant bone tumors. J Orthop Sci. 2010;15:340–9.
Shimozaki S, Yamamoto N, Shirai T, et al. Pedicle versus free frozen autograft for reconstruction in malignant bone and soft tissue tumors of the lower extremities. J Orthop Sci. 2014;19:156–63.
Chen WM, Wu PK, Chen CF, et al. High-grade osteosarcoma treated with hemicortical resection and biological reconstruction. J Surg Oncol. 2011;105:825–9.
Igarashi K, Yamamoto N, Shirai T, et al. The long-term outcome following the use of frozen autograft treated with liquid nitrogen in the management of bone and soft-tissue sarcomas. Bone Joint J. 2014;96-B:555–61.
Nishida H, Shirai T, Hayashi K, et al. Cryotreatment against metastatic renal cell bone tumour reduced multiple lung metastases. Anticancer Res. 2011;31:2927–30.
Nishida H, Yamamoto N, Tanzawa Y, et al. Cryoimmunology for malignant bone and soft-tissue tumors. Int J Clin Oncol. 2011;16:109–17.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer Japan
About this chapter
Cite this chapter
Tsuchiya, H., Yamamoto, N. (2016). Biological Reconstruction for Extremity Osteosarcoma: Liquid Nitrogen-Treated Tumor-Bearing Bone Graft. In: Ueda, T., Kawai, A. (eds) Osteosarcoma. Springer, Tokyo. https://doi.org/10.1007/978-4-431-55696-1_15
Download citation
DOI: https://doi.org/10.1007/978-4-431-55696-1_15
Published:
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-55695-4
Online ISBN: 978-4-431-55696-1
eBook Packages: MedicineMedicine (R0)