Abstract
The kidney, adrenal gland, and retroperitoneum are important sites of disease in the pediatric population. Some of the most frequently encountered childhood neoplasms, including Wilms tumor and neuroblastoma, arise in the kidney and adrenal gland, respectively. Many of these tumors are deep-seated but amenable to fine-needle aspiration (FNA). Children with a renal, adrenal, or retroperitoneal malignancy may present at an advanced stage and be too ill to withstand the rigors of surgery. Thus, neoadjuvant chemotherapy may be used to debulk some of these tumors before surgery is performed, and an accurate cytologic diagnosis is imperative to ensure the appropriate management is undertaken. This chapter covers both common and more unusual lesions that may be encountered when looking at an FNA from this area. In addition, urine cytology in children is discussed briefly.
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References
Husain AN, Stocker JT, editors. Color atlas of pediatric pathology. New York, NY: Demos Medical Publishing; 2011.
Kini S. Color atlas of differential diagnosis in exfoliation and aspiration cytopathology. 2nd ed. Philadelphia, PA: Wolters Kluwer/Lippincott Williams & Wilkins; 2011.
Yang D, Jung D, Kim H, Kang J, Kim S, Kim J, Hwang H. Retroperitoneal cystic masses: CT, clinical and pathologic findings and literature review. Radiographics. 2004;24:1353–65.
Stocker J, Dehner L, editors. Pediatric pathology. 2nd ed. Philadelphia, PA: Lippincott, Williams and Wilkins; 2001.
Khalbuss W, Monaco S, Pantanowitz L. Quick compendium of cytopathology. Chicago: ASCP Press; 2013.
Shohab D, Hussain I, Khawaia A, Jamil I, Raia NU, Ahmed F, Akhter S. Primary renal aspergillosis and xanthogranulomatous pyelonephritis in an immune-competent toddler. J Coll Physicians Surg Pak. 2014;24:S101–3.
Silowash R, Monaco SE, Pantanowitz L. Ancillary techniques on direct-smear aspirate slides: a significant evolution for cytopathology techniques. Cancer Cytopathol. 2013;121:670.
Iyer V, Agarwala S, Verma K. Fine needle aspiration cytology of clear cell sarcoma of the kidney: study of eight cases. Diagn Cytopathol. 2005;33:83–9.
Portugal R, Barroca H. Clear cell sarcoma, cellular mesoblastic nephroma and metanephric adenoma: cytological features and differential diagnosis with Wilms tumor. Cytopathology. 2008;19:80–5.
Brownlee NA, Perkins LA, Stewart W, Jackle B, Pettenati MJ, Koty PP, Iskandar SS, Garvin AJ. Recurring translocation (10;17) and deletion (14q) in clear cell sarcoma of the kidney. Arch Pathol Lab Med. 2007;131:446–51.
Sharifah N. Fine needle aspiration cytology characteristics of renal tumors in children. Pathology. 1994;26:359–64.
Cheng JX, Tretiakova M, Gong C, Mandal S, Krausz T, Taxy JB. Renal medullary carcinoma: rhabdoid features and the absence of INI1 expression as markers of aggressive behavior. Mod Pathol. 2008;21:647–52.
Schinstine M, Filie A, Torres-Cabala C, et al. Fine needle aspiration of Xp11.2 translocation/TFE3 fusion renal cell carcinoma metastatic to the lung: report of a case and review of the literature. Diagn Cytopathol. 2006;34:751–6.
Ramphal R, Pappo A, Zielenska M, Grant R, Ngan BY. Pediatric renal cell carcinoma: clinical, pathologic, and molecular abnormalities associated with the members of the mit transcription factor family. Am J Clin Pathol. 2006;126:349–64.
Barman S, Mandal KC, Mukhopadhyay M. Adrenal myelolipoma: an incidental and rare benign tumor in children. J Indian Assoc Pediatr Surg. 2014;19:236–8.
Davidoff A. Neuroblastoma. Semin Pediatr Surg. 2012;21:2–14.
Durell J, Dagash J, Eradi B, Nour S. Pediatric benign cystic mesothelioma. J Pediatr Adolesc Gynecol. 2016;29:e33–4.
Crapazano J, Cardillo M, Lin O, Zakowski M. Cytology of desmoplastic small round cell tumor. Cancer. 2002;96:21–31.
Arnold MA, Schoenfield L, Limketkai BN, Arnold CA. Diagnostic pitfalls of differentiating desmoplastic small round cell tumor (DSRCT) from Wilms tumor (WT): overlapping morphologic and immunohistochemical features. Am J Surg Pathol. 2014;38:1220–6.
Tsokos M, Alaggio R, Dehner L, Dickman P. Ewing sarcoma/peripheral primitive neuroectodermal tumor and related tumors. Pediatr Dev Pathol. 2012;15(1 Suppl):108–26.
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Michelow, P., Dubb, M. (2017). Kidney, Adrenal Gland, and Retroperitoneum. In: Monaco, S., Teot, L. (eds) Pediatric Cytopathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53441-0_7
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DOI: https://doi.org/10.1007/978-3-662-53441-0_7
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