Definition
The cullin-RING ubiquitin E3 ligases (CRLs) are the largest family of multi-subunit ubiquitin E3 ligases in eukaryotes. CRLs share a structural archetype characterized by the presence of interchangeable substrate receptors assembled onto a core catalytic complex consisting of a cullin family member and a RING protein, RBX1 (ROC1 or Hrt1) or RBX2 (ROC2). The members of the human cullin family comprise cullin 1 (CUL1, CDC53), cullin 2 (CUL2), cullin 3 (CUL3), cullin 4A (CUL4A), cullin 4B (CUL4B), cullin 5 (CUL5), cullin 7 (CUL7), and cullin 9 (CUL9), each serves as a scaffold protein to assemble a subfamily of CRL E3 ligases. A cullin uses a conserved globular C-terminal domain (cullin homology domain) to recruit the catalytic RING protein and a series of N-terminal repeats of a five-helix bundle (cullin repeats) to modularly interact with different adaptor proteins and substrate receptors...
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References
Jackson S, Xiong Y (2009) CRL4s: the CUL4-RING E3 ubiquitin ligases. Trends Biochem Sci 34:562–570
Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW (2004) Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev 18:2573–2580
Petroski MD, Deshaies RJ (2005) Function and regulation of cullin-RING ubiquitin ligases. Nat Rev Mol Cell Biol 6:9–20
Stogios PJ, Downs GS, Jauhal JJ, Nandra SK, Prive GG (2005) Sequence and structural analysis of BTB domain proteins. Genome Biol 6:R82
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Zhang, H. (2016). Cullin Ubiquitin E3 Ligases. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-46875-3_7191
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DOI: https://doi.org/10.1007/978-3-662-46875-3_7191
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