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Postersession VI

Infektionskrakheiten

  • Conference paper
90. Kongreß

Zusammenfassung

Mezlozillin ist ein Ureidopenizillin mit Wirkung gegen ein breites Spektrum grampositiver und gramnegativer Bakterien. Die Ausscheidung des organischen Anions Mezlozillin (pKa 3,5) erfolgt renal und biliär. Es wurde diskutiert, daß die beim Menschen beschriebene nichtlineare Kinetik mit dem Transport von Mezlozillin in der Leber in Zusammenhang steht [3]. Bei den vorliegenden Experimenten wurde der Mezlozillineinstrom in die Leber (zelluläre Aufnahme), also der sinusoidale Plasmamembrantransport in isolierten Rattenlebern untersucht.

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Literatur

  1. Gärtner U, Stockert RJ, Morell AG, Wolkoff AW (1981) Modulation of the transport of Bi1irubin and Asia1oorosomucoid during liver regeneration. Hepatology 1: 99–106

    Article  PubMed  Google Scholar 

  2. Goresky CA (1964) Initial distribution and rate of uptake of sulfobromophthalein in the liver. Am J Physio1207: 13–26

    Google Scholar 

  3. Gundert-Remy U, Hildebrandt R, Stiehl A, Weber E (1983) Nonlinear Mezlocillin kinetics due to dose-dependent metabolism. Clin Pharmacol Ther 33: 656–662

    Article  PubMed  CAS  Google Scholar 

  4. Bennet S, Wise R, Weston D, Dent J (1983) Pharmacokinetics and tissue penetration of ticarcillin combined with clavulanic acid. Antimicrob Agents Chemother 23: 831–834

    Article  Google Scholar 

  5. Hallermann W, Lode H, Koeppe P, Dzwillo G (1978) Vergleichende Pharmakokinetik von Carbenicillin und Ticarcillin bei chronischen Bronchitikern. Atemwegs Lungenkr 4: 303–304

    Google Scholar 

  6. Kienel G (1976) Vergleich der Pharmakokinetik von Epicillin und Ampicillin. Drug Res 26: 781–789

    Google Scholar 

  7. Libke RD, Clarke JT, Ralph CD, Lathy RP, Kirby WMM (1975) Ticarcillin vs carbenicillin: Clinical pharmacokinetics. Clin Pharmacol Ther 17: 441–446

    Google Scholar 

  8. Lode H, Madey V, Dzwillo G, Borner K, Koeppe P (1983) Serum bactericidal activity and kinetics of azlocillin and moxalactam after single and combined administration.

    Google Scholar 

  9. J Antimicrob Chemother (Suppl B) 11: 121–126

    Google Scholar 

  10. Witkowski G, Lode H, Höffken G, Koeppe P (1982) Pharmacokinetic studies of amoxicillin, potassium clavunate and their combination. Eur J Clin Microbiol 1: 233–237

    Article  PubMed  CAS  Google Scholar 

  11. Stratton CW, Reller L (1977) Serum dilution test for bactericidal activity. J Infect Dis 136: 187–195

    Article  PubMed  CAS  Google Scholar 

  12. Borner K, Lode H, Elvers A (1982) Determination of apalcillin and its metabolites in humxan body fluid by high-pressure liquid chromatography. Antimicrob Agents Chemother 22: 949–953

    Article  PubMed  CAS  Google Scholar 

  13. Busch U, Heinzel G, Seyfrath H, Mielenz H (1982) Untersuchung zur Pharmakokinetik von Apalcillin beim Menschen. Arzneim Forsch 32: 1131–1135

    CAS  Google Scholar 

  14. Komatsu T, Noguchi H, Tohishi H, Nakagome T (1981) Apalcillin (PC904) and its related compounds. In: Mitsuhashi T (ed) Beta-lactam antibiotics. Japan Scientific Societies Press, Tokyo, pp 87–98

    Google Scholar 

  15. Reeves D, Bywater MJ (1976) Assay of antimicrobial agents. In: de Louvois J (ed) Selected topics in clinical bacteriology. Baillière Tindall, London, pp 27–78

    Google Scholar 

  16. Stille W, Helm E, Mielenz H (1982) Untersuchungen zur antibakteriellen Aktivität von Apalcillin. Arzneim Forsch 32: 1128–1130

    CAS  Google Scholar 

  17. Lode H, Stahlmann R, Koeppe P (1979) Comparative pharmacokinetics of cephalexin, cefaclor, cefadroxil, ând CGP 9000. Antimicrob Agents Chemother 16: 1–6

    Article  PubMed  CAS  Google Scholar 

  18. Lode H, Elvers A, Koeppe P, Borner K (1984) Comparative pharmacokinetics of apalcillin and piperacillin. Antimicrob Agents Chemother 25: 105–108

    Article  PubMed  CAS  Google Scholar 

  19. Bryan LE, Kwan S (1981) Aminoglycoside-resistant mutants of Pseudomonas aeruginosa deficient in cytochrome d, nitrite reductase, and aerobic transport. Antimicrob Agents Chemother 19: 958–964

    Article  PubMed  CAS  Google Scholar 

  20. Gaman. W, Cates C, Snelling CFT, Lank B, Ronald AR (1976) Emergence of gentamicin-and carbenicillin-resistant Pseudomonas aeruginosa in a hospital environment. Antimicrob Agents Chemother 9: 474–480

    Google Scholar 

  21. Grasso S, Meinardi G, Carneri I, Tamassia V (1978) New in vitro model to study the effect of antibiotic concentration and rate of elimination on antibacterial activity. Antimicrob Agents Chemother 13: 570–576

    Article  PubMed  CAS  Google Scholar 

  22. John JF, Rubens CE, Farrar WE (1980) Characteristics of gentamicin resistance in nosocomial infections. Am J Med Sci 279: 25–30

    Article  PubMed  CAS  Google Scholar 

  23. National Committee for Clinical Laboratory Standards (1983) Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Tentative Standard, Jan. 1983, Villanova, Pa.

    Google Scholar 

  24. Phillips I, King BA, Shannon KP (1978) The mechanisms of resistance to aminoglycosides in the genus Pseudomonas. J Antimicrob Chemother 4: 121–129

    Article  PubMed  CAS  Google Scholar 

  25. Weinstein RA, Nathan C, Gruensfelder R, Kabins SA (1980) Endemic aminoglycoside resistance in gram-negative bacilli: Epidemiology and mechanisms. J Infect Dis 141: 338–345

    Google Scholar 

  26. Annapurna E, Sanyal SC (1977) Enterotoxicity of Aeromonas hydrophila. J Med Microbiol 10: 317–323

    Article  PubMed  CAS  Google Scholar 

  27. Burke V, Robinson J, Berry RJ, Gracey M (1981) Detection of enterotoxins of Aeromonas hydrophila by a suckling-mouse test. J Med Microbiol 14: 401–408

    Article  PubMed  CAS  Google Scholar 

  28. Ljungh A, Popoff M, Wadström T (1977) Aeromonas hydrophila in acute diarrheal disease: detection of enterotoxin and biotyping of strains. J Clin Microbiol 6: 96–100

    PubMed  CAS  Google Scholar 

  29. Wolff RL, Wiseman SL, Kitchens CS (1980) Aeromonas hydrophila bacteremia in ambulatory immunocompromised hosts. Am J Med 68: 238–242

    Article  PubMed  CAS  Google Scholar 

  30. Helwig H (1981) Prophylaxe der Meningokokkenmeningitis. Dtsch Med Wochenschr 106: 25–27

    Article  PubMed  CAS  Google Scholar 

  31. Kirch W, Gizicky C, Ohler W (1983) Foudroyante Penicillin G-resistente Meningokokkensepsis beim Erwachsenen. Verh Dtsch Ges Inn Med 89: 1219–1221

    Google Scholar 

  32. Künzer W, Schindera F, Schenck W, Schuhmacher H (1972) Waterhouse-Friderichsen-Syndrom. Dtsch Med Wochenschr 97: 270–273

    Article  PubMed  Google Scholar 

  33. Sutor AH (1982) Meningokokkensepsis. Dtsch Med Wochenschr 107: 1776–1778

    PubMed  CAS  Google Scholar 

  34. Sutor AH, Künzer W (1977) Zur Problematik der Streptokinasedosierung im Kindesalter. Monatsschr Kinderheilkd 125: 533–538

    PubMed  CAS  Google Scholar 

  35. Vogel GE (1983) Klinische Bedeutung von Antithrombin III. Schriftenreihe der Bayr. Landesärztekammer 61: 99–106

    Google Scholar 

  36. Vogel GE, v Clarmann M, Komm Ch, Wirtzfeld A, Oberdorfer A (1984) Antithrombin III in der Diagnostik und Therapie der Verbrauchskoagulopathie. Intensivmedizin (im Druck)

    Google Scholar 

  37. Greene JB, Sidhu GS, Lewin S, Levine JF, Masur H, Simberkoff MS, Nicholas P, Good RC, Zolla-Pazner SB, Pollock AA, Tapper ML, Holzmann RS (1982) Mycobacterium avium-intracellulare: A cause of disseminated life-threatening infection in homosexuals and drug abusers. Ann Intern Med 97: 539–546

    Google Scholar 

  38. Jäger H (1983) AIDS Das acquired immune deficiency syndrome. Dtsch Ärztebl 26: 23–32

    Google Scholar 

  39. Müller SA, Herrmann EC Jr, Winkelmann RK (1972) Herpes simplex infections in hematologic malignancies. Am J Med 52: 102–114

    Article  PubMed  Google Scholar 

  40. Siegal, FP, Lopez C, Hammer GS, Brown AE, Kornfeld SJ, Gold J, Hassett J, Hirschmann SZ, Cunningham-Rundles C, Adelsberg BA, Parham DM, Siegal M, Cunnigham-Rundles S, Armstrong D (1981) Severe acquired immundeficiency in male homosexuals, manifested by chronic perianal ulcerative herpes simplex lesions. N Engl J Med 305: 1439–1444

    Article  PubMed  CAS  Google Scholar 

  41. Zakowski P, Fligiel S, Berlin OGW, Johnson L (1982) Disseminated Mycobacterium avium-intracellulare infection in homosexual men dying of acquired immunodeficiency. JAMA 248: 2980–2982

    Article  PubMed  CAS  Google Scholar 

  42. Armstrong JA, Evans AS, Rao N, Ho M (1976) Viral infections in renal transplant recipients. Infect Immun 14: 970–975

    PubMed  CAS  Google Scholar 

  43. Canadian Multicentre Transplant Study Group (1983) A randomized trial of cyclosporine in cadaveric renal transplantation. N Engl J Med 309: 809–815

    Article  Google Scholar 

  44. Dennin RH, Herhahn J, Schulz E, Sack K (1984) Serologische Cytomegalie-Diagnostik mittels Elisa-Technik bei nierentransplantierten Patienten. Dtsch Med Wochenschr 109: 214–218

    Article  PubMed  CAS  Google Scholar 

  45. Hirsch MS, Schooley RT (1983) Treatment of Herpesvirus infections. N Engl J Med 309: 1034–1039

    Article  Google Scholar 

  46. Ho M (1977) Virus infections after transplantation in man. Arch Virol 55: 1–24

    Article  PubMed  CAS  Google Scholar 

  47. Mitchell CD, Gentry SR, Boen JR (1981) Acyclovir therapy for HSV-infections. Lancet 1: 1389–1392

    Article  PubMed  CAS  Google Scholar 

  48. Wade JA, Newton B, McLaren C,Flournoy N (1982) Intravenous Acyclovir to treat HSV-infection. Ann Intern Med 96: 265–269

    CAS  Google Scholar 

  49. Walker DP, Longson M, Mallick NP, Johnson RWG (1982) A prospective study of CMV and HSV disease after renal transplantation. J Clin Pathol 35: 1190–1193

    Article  PubMed  CAS  Google Scholar 

  50. British Society fo Antimicrobial Chemotherapy (1982) The antibiotic prophylaxis of infective endocarditis. Lancet 2: 1323–1326

    Google Scholar 

  51. Editorial (1984) Infective endocarditis. Lancet 1: 603–604

    Google Scholar 

  52. Gersony WM, Hayes CJ (1977) Bacterial endocarditis in patients with pulmonary stenosis, aortic stenosis or ventricular septal defect. Circulation (Suppl I ) 56: 84–87

    Google Scholar 

  53. Jackson GG, Geiseler PJ, White GW, Eckner FAO (1983) Infective endocarditis. In: Spittler JA (ed) Clinical medicine. Harper-Row, Philadelphia

    Google Scholar 

  54. Levison ME, Kaye D, Mandell GL, Hook EH (1970) Characteristics of patients with multiple episodes of bacterial endocarditis. JAMA 211: 1355–1357

    Article  PubMed  CAS  Google Scholar 

  55. Niebel J, Häussinger K, Meister W, Held E (1984) Die antimikrobielle Prophylaxe der infektiösen Endocarditis. Dtsch Med Wochenschr (im Druck)

    Google Scholar 

  56. Reisberg BE (1979) Infective endocarditis in the narcotic addict. Prog Cardiovasc Dis 22: 193–204

    Article  PubMed  CAS  Google Scholar 

  57. Welton BE, Young JB, Gentry WO, Alexander JK, Chahine RA, Miller RR (1979) Recurrent infective endocarditis. Analysis of predisposing factors and clinical features. Am J Med 66: 932–938

    Google Scholar 

  58. Ayres SJ, Goff JS, Warren GH (1983) Endoscopic sclerotherapy for bleeding esophageal varices: effects and complications. Ann Intern Med 98: 900

    Article  PubMed  CAS  Google Scholar 

  59. Camara DS, Gruber M, Barde CJ, Montes M, Caruana JA, Chung RS (1983) Transient bacteremia following endoscopic injection sclerotherapy of esophageal varices. Arch Intern Med 143: 1350–1352

    Article  PubMed  CAS  Google Scholar 

  60. Cohen LB, Korsten MA, Scherl EJ, Velez ME, Fisse RD, Arons EJ (1983) Bacteremia after endoscopic injection sclerosis. Gastrointest Endosc 29: 198

    Article  PubMed  CAS  Google Scholar 

  61. Evans DM, Jones DB, Cleary BK, Smith PM (1982) Oesophageal varices treated by sclerotherapy: a histopathological study. Gut 23: 615

    Article  PubMed  CAS  Google Scholar 

  62. Helpap B, Bollweg L (1981) Morphological changes in the terminal oesophagus with varices, following sclerosis of the wall. Endoscopy 13: 229

    Article  PubMed  CAS  Google Scholar 

  63. Macdougall BR, Westaby D, Theodossi A, Dawson JL, Williams R (1982) Increased long-term survival in variceal haemorrhage using injection sclerotherapy. Lancet 1: 124

    Article  PubMed  CAS  Google Scholar 

  64. O’Connor HJ, Hamilton I, Lincoln C, Maxwell S, Axon ATR (1983) Bacteraemia with upper gastrointestinal endoscopy a reappraisal. Endoscopy 2: 21

    Article  Google Scholar 

  65. Pugh RNH, Murray-Lyon JM, Dawson JL, Pietroni MC, Williams R (1973) Transsection of the oesophagus for bleeding oesophageal varices. Br J Surg 60: 646

    Article  PubMed  CAS  Google Scholar 

  66. Terblanche J, Northover JMA, Bornman P, Kahn D, Silber W, Barbezat GO, Sellars S, Campbell JA, Saunders SJ (1979) A prospective controlled trial of sclerotherapy in the long term management of patients after esophageal variceal bleeding. Surg Gynecol Obstet 148: 323

    PubMed  CAS  Google Scholar 

  67. Braude AI (1980) Endotoxic immunity. Adv Intern Med 26: 427–445

    PubMed  CAS  Google Scholar 

  68. Drews J (1983) Immunomodulation. In: Easmon CSF, Gaya H (eds) Second international symposium on infections in the immunocompromised host. Academic Press, London New York Paris, p 61

    Google Scholar 

  69. Finland M (1970) Changing ecology of bacterial infections as related to antibacterial therapy. J Infect Dis 122: 419–431

    Article  PubMed  CAS  Google Scholar 

  70. Greisman Sh E, DuBuy JB, Woodward CL (1979) Experimental gramnegative bacterial sepsis: prevention of mortality not preventable by antibiotics alone. Infect Immun 25: 538–557

    PubMed  CAS  Google Scholar 

  71. Haranaka K, Sugane K, Mashimo K (1975) Combination therapy of anti-endotoxin antibody and gentamicin in the immunosuppressed mice with Pseudomonas aeruginosa infection. Jpn J Exp Med 45: 207–213

    PubMed  CAS  Google Scholar 

  72. Jones RJ, Roe EA, Gupta JL (1979) Controlled trial of pseudomonas immunoglobulin and vaccine in burned patients. Lancet 2: 1263–1265

    Google Scholar 

  73. Jones RJ (1981) Vaccines and antisera against gram-negative bacilli. J Hosp Infect 2: 105–111

    Article  PubMed  CAS  Google Scholar 

  74. Kreger BE, Craven DE, McCabe WR (1980) Gram-negative bacteremia. IV. Re-evaluation of clinical features and treatment in 612 patients. Am J Med 68: 344–355

    Article  PubMed  CAS  Google Scholar 

  75. McCabe WR (1975) Antibiotics and endotoxic shock. Bull NY Acad Med 51: 1084–1095

    CAS  Google Scholar 

  76. Neter E, Bertram LF, Arbesman CE (1952) Demonstration of Escherichia coli O 55 and O 111 antigens by means of hemagglutination test. Proc Soc Exp Biol Med 79: 255–257

    Article  PubMed  CAS  Google Scholar 

  77. Stendahl O, Tagesson C, Magnusson KE, Edebo L (1977) Physicochemical consequences of opsonization of Salmonella typhimurium with hyperimmune IgG and complement. Immunology 32: 11–18

    PubMed  CAS  Google Scholar 

  78. Traub WH (1983) Passive protection of NMRI mice against Serratia marcescens: comparative efficacy of commercial human IgG immunoglobulin preparations and rabbit anti-O, -H, -live cell and -protease immune sera. Zentralbl Bakteriol [Orig A] 254: 480–488

    CAS  Google Scholar 

  79. Trautmann M, Bruckner O, Hahn H (1982) Schutzwirkung von pseudomonas-spezifischem Hyperimmunglobulin vom Kaninchen and aktiver Immunisierung bei experimenteller Pseudomonas-Sepsis der Maus. Zentralbl Bakteriol [Orig A] 252: 370–383

    CAS  Google Scholar 

  80. Zinner St H, McCabe WR (1976) Effects of IgM and IgG antibody in patients with bacteremia due to gram-negative bacilli. J Infect Dis 133: 37–45

    Article  PubMed  CAS  Google Scholar 

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Gärtner, U. et al. (1984). Postersession VI. In: 90. Kongreß. Verhandlungen der Deutschen Gesellschaft für Innere Medizin, vol 90. J.F. Bergmann-Verlag, Munich. https://doi.org/10.1007/978-3-642-85457-6_78

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  • DOI: https://doi.org/10.1007/978-3-642-85457-6_78

  • Publisher Name: J.F. Bergmann-Verlag, Munich

  • Print ISBN: 978-3-8070-0342-9

  • Online ISBN: 978-3-642-85457-6

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