Abstract
In response to transient cerebral ischemia there is an increase in microvascular permeability and a corresponding loss of parenchymal function. The increase in vascular permeability can result in vasogenic cerebral edema and subsequent prolonged hypoperfusion of affected CNS regions thereby exacerbating regional cerebral damage (Chan et al. 1984). The mechanisms resulting in the endothelial damage are not well defined. Therefore, to characterize the specific changes in the cerebral circulation during focal ischemia/reperfusion we have developed a model in the rabbit to simultaneously evaluate regional CNS blood flow and microvascular integrity.
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References
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© 1989 Springer-Verlag Berlin Heidelberg
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Tasdemiroglu, E., Christenberry, D.P., Ardell, J.L., Chronister, R., Curreri, P.W., Taylor, A.E. (1989). Ischemia-Reperfusion Injury in the Rabbit Brain. In: Hoff, J.T., Betz, A.L. (eds) Intracranial Pressure VII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73987-3_240
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DOI: https://doi.org/10.1007/978-3-642-73987-3_240
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73989-7
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